Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

TRXR1 is a selenocysteine-containing protein that is involved in redox homeostasis. Its canonical target is thioredoxin, another redox protein. Together, they are involved in many functions such as antioxidant regulation, cell proliferation, DNA replication, and transcription. TRXR1 is also capable of reducing a wide array of cellular proteins. Selenium deficiency, either by diet modification or introduction of methylmercury, hinders proper expression and function of TRXR1. It is possible that this effect, which results in a higher oxidative state, is a result of the selenocysteine codon being read as a STOP codon in the absence of adequate selenium. The functions of TRXR1 in cell proliferation and antioxidant defense make it a potential therapeutic target.

References

[1] Turanov, A.A. et al. (2010) Biochem J 430, 285-93.
[2] Gasdaska, P.Y. et al. (1995) FEBS Lett 373, 5-9.
[3] Gromer, S. et al. (2004) Med Res Rev 24, 40-89.
[4] Usuki, F. et al. (2011) J Biol Chem 286, 6641-9.
[5] Pappas, A.C. et al. (2008) Comp Biochem Physiol B Biochem Mol Biol 151, 361-72.
[6] Müller, M. et al. (2010) Genes Nutr 5, 297-307.

Raw materials

Preparation Products