Ethyl 2-methylnicotinate
- CAS No.
- 1721-26-2
- Chemical Name:
- Ethyl 2-methylnicotinate
- Synonyms
- 2-methylnicotin ethyl ester;Ethyl 2-methylnicotite;ethyle2-methylnicotinate;ETHYL 2-METHYLNICOTINATE;Ethyl 2-methylinicotinate;Ethyl2-Methylnicotinate>Ethyl2-methylnicotinate,97%;Ethyl 2-methylnicotinate 98%;2-METHYLNICOTINIC ACID ETHYL ESTER;ethyl 2-methylpyridine-3-carboxylate
- CBNumber:
- CB5663967
- Molecular Formula:
- C9H11NO2
- Molecular Weight:
- 165.19
- MDL Number:
- MFCD00006336
- MOL File:
- 1721-26-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl 2-methylpyridine-3-carboxylate 97% | 325201 | 5g | $89.5 |
| Ethyl 2-Methylnicotinate >98.0%(GC)(T) | E0860 | 5g | $43 |
| Ethyl 2-Methylnicotinate >98.0%(GC)(T) | E0860 | 25g | $193 |
| Ethyl 2-methylnicotinate ≥98% | CS-W010821 | 25g | $48 |
| Ethyl 2-methylnicotinate ≥98% | CS-W010821 | 100g | $190 |
| More product size | |||
| Melting point | 146-147 °C |
|---|---|
| Boiling point | 126-127 °C24 mm Hg(lit.) |
| Density | 1.072 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 217 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 4.02±0.10(Predicted) |
| form | Liquid |
| color | Clear colorless to orange |
| Water Solubility | Slightly soluble in water. |
| λmax | 268nm(EtOH)(lit.) |
| BRN | 118200 |
| InChI | InChI=1S/C9H11NO2/c1-3-12-9(11)8-5-4-6-10-7(8)2/h4-6H,3H2,1-2H3 |
| InChIKey | TZORNSWZUZDUCU-UHFFFAOYSA-N |
| SMILES | C1(C)=NC=CC=C1C(OCC)=O |
| CAS DataBase Reference | 1721-26-2(CAS DataBase Reference) |
| FDA UNII | F7SS2LF4HT |
| NIST Chemistry Reference | Ethyl 2-methylnicotinate(1721-26-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
Ethyl 2-methylnicotinate price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 325201 | Ethyl 2-methylpyridine-3-carboxylate 97% | 1721-26-2 | 5g | $89.5 | 2023-06-20 | Buy |
| TCI Chemical | E0860 | Ethyl 2-Methylnicotinate >98.0%(GC)(T) | 1721-26-2 | 5g | $43 | 2026-04-30 | Buy |
| TCI Chemical | E0860 | Ethyl 2-Methylnicotinate >98.0%(GC)(T) | 1721-26-2 | 25g | $193 | 2024-03-01 | Buy |
| ChemScene | CS-W010821 | Ethyl 2-methylnicotinate ≥98% | 1721-26-2 | 25g | $48 | 2026-06-04 | Buy |
| ChemScene | CS-W010821 | Ethyl 2-methylnicotinate ≥98% | 1721-26-2 | 100g | $190 | 2026-06-04 | Buy |
Ethyl 2-methylnicotinate Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid
Uses
Ethyl 2-methylpyridine-3-carboxylate was used in the preparation of amino esters such as ethyl 2(piperidinylaminomethyl)benzoate, ethyl 2-(N-benzyl-N-methylaminomethyl)benzoate, ethyl 2-(diethylaminomethyl)benzoate.
Synthesis
A method for the preparation of Ethyl 2-methylnicotinate, as follows:
(1) 2.0 mol of 1,1,3,3-tetramethoxypropane was added into a reactor at room temperature, 2.5 mol of hydrochloric acid at a mass concentration of 20% was added with stirring, and the reaction was carried out at a controlled temperature of 40 C. for 4 hours; the 2.5 mol refers to the molar amount of HCl in the hydrochloric acid, and the following is the same;
( 2) adding 1 mol of -aminocrotonic acid methyl ester, 6 mol of methanol to the reactor, controlling the reaction temperature at 50C, and reacting for 6 hours;
wherein the molar ratio of -aminocrotonic acid methyl ester, 1,1,3,3-tetramethoxypropane, hydrochloric acid, and methanol was 1.0:2.0:2.5:6.0;
(3) reducing pressure and concentrating the above reaction solution (3)Concentrate the above reaction solution under reduced pressure, neutralize the concentrated solution with 10% aqueous sodium hydroxide solution to the system pH=5.0, add 5 times the mass of -aminocrotonic acid methyl ester of ethyl acetate to the system, extract the fractional phase, add 4 times the mass of -aminocrotonic acid methyl ester of water to the organic phase, wash the fractional phase, concentrate the organic phase, and then continue to distil with a small rotary-vane vacuum pump to collect the fractions, to obtain the liquid of 2-methyl nicotinic acid methyl ester 105.9 g , with a yield of 70.1% and a purity of 98.45%.
Ethyl 2-methylnicotinate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from Ethyl 2-methylnicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | Ethyl 2-methylnicotinate
1721-26-2
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-06 | Ethyl 2-methylnicotinate
1721-26-2
|
$1.00 | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- Ethyl 2-methylnicotinate
1721-26-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Ethyl 2-methylnicotinate
1721-26-2
- $1.00
- 98%
- Career Henan Chemical Co
