4-Chloro-3-nitrobenzaldehyde
- CAS No.
- 16588-34-4
- Chemical Name:
- 4-Chloro-3-nitrobenzaldehyde
- Synonyms
- ASISCHEM R36965;AKOS BBS-00003244;TIMTEC-BB SBB007674;4-Chlor-3-nitrobenzaldehyde;4-chloro-3-nitro-benzaldehyd;4-CHLORO-3-NITROBENZALDEHYDE;3-NITRO-4-CHLOROBENZALDEHYDE;Benzaldehyde, 4-chloro-3-nitro-;1-Chloro-4-formyl-3-nitrobenzene;4-Chloro-3-nitrobenzaldehyde,97%
- CBNumber:
- CB5671355
- Molecular Formula:
- C7H4ClNO3
- Molecular Weight:
- 185.56
- MDL Number:
- MFCD00007078
- MOL File:
- 16588-34-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Chloro-3-nitrobenzaldehyde 98% | C58703 | 25g | $233 |
| 4-Chloro-3-nitrobenzaldehyde 98% | C58703 | 5g | $43.3 |
| 4-Chloro-3-nitrobenzaldehyde >95.0%(T) | C1165 | 5g | $27 |
| 4-Chloro-3-nitrobenzaldehyde >95.0%(T) | C1165 | 25g | $75 |
| 3-Nitro-4-chlorobenzaldehyde Asreported | 285831 | 25g | $409 |
| More product size | |||
| Melting point | 61-63 °C (lit.) |
|---|---|
| Boiling point | 276.5°C (rough estimate) |
| Density | 1.4791 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 4g/l |
| form | Powder |
| color | Off-white to light yellow to light green |
| Water Solubility | 4 g/L (98 ºC) |
| Sensitive | Air Sensitive |
| BRN | 778323 |
| InChI | 1S/C7H4ClNO3/c8-6-2-1-5(4-10)3-7(6)9(11)12/h1-4H |
| InChIKey | HETBKLHJEWXWBM-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1cc(C=O)ccc1Cl |
| CAS DataBase Reference | 16588-34-4(CAS DataBase Reference) |
| FDA UNII | 389H8733F1 |
| NIST Chemistry Reference | 4-Chloro-3-nitrobenzaldehyde(16588-34-4) |
| EPA Substance Registry System | Benzaldehyde, 4-chloro-3-nitro- (16588-34-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-43 | |||||||||
| Safety Statements | 26-36/37-36/37/39-22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29130000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
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| NFPA 704 |
|
4-Chloro-3-nitrobenzaldehyde price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C58703 | 4-Chloro-3-nitrobenzaldehyde 98% | 16588-34-4 | 25g | $233 | 2026-04-30 | Buy |
| Sigma-Aldrich | C58703 | 4-Chloro-3-nitrobenzaldehyde 98% | 16588-34-4 | 5g | $43.3 | 2023-06-20 | Buy |
| TCI Chemical | C1165 | 4-Chloro-3-nitrobenzaldehyde >95.0%(T) | 16588-34-4 | 5g | $27 | 2026-04-30 | Buy |
| TCI Chemical | C1165 | 4-Chloro-3-nitrobenzaldehyde >95.0%(T) | 16588-34-4 | 25g | $75 | 2026-04-30 | Buy |
| Usbiological | 285831 | 3-Nitro-4-chlorobenzaldehyde Asreported | 16588-34-4 | 25g | $409 | 2026-06-03 | Buy |
4-Chloro-3-nitrobenzaldehyde Chemical Properties,Uses,Production
Chemical Properties
Light yellow powder
Uses
4-Chloro-3-nitrobenzaldehyde is a potent inhibitor of VCAM-1 expression and a potential drug candidate for autoimmune and allergic inflammatory diseases.
Synthesis
104-88-1
16588-34-4
General procedure for the synthesis of 4-chloro-3-nitrobenzaldehyde from 4-chlorobenzaldehyde: 4-chlorobenzaldehyde (70 g, 0.5 mol) was added in batches to a mixture of nitrosonitrous nitric acid (55 mL) and sulfuric acid (55 mL) at 5°C with continuous stirring for 2 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ice water (1 L) while stirring was maintained. Subsequently, the precipitate was collected by filtration and recrystallized with ethanol/water solvent mixture to afford the target product 4-chloro-3-nitrobenzaldehyde (90 g, 97% yield) as white needle-like crystals. The melting point of the product was 62-63 °C.
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 4, p. 657 - 667
[2] European Journal of Medicinal Chemistry, 2014, vol. 77, p. 361 - 377
[3] Journal of Chemical Research, 2008, # 12, p. 722 - 724
[4] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2013, vol. 43, # 8, p. 977 - 983
[5] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2014, vol. 44, # 7, p. 921 - 926
4-Chloro-3-nitrobenzaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 4-Chloro-3-nitrobenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | 4-Chloro-3-nitrobenzaldehyde
16588-34-4
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2022-02-10 | 4-Chloro-3-nitrobenzaldehyde
16588-34-4
|
1KG | 99.5% | 100 tons | Honest Joy Holdings Limited
|
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2020-02-26 | 4-Chloro-3-nitrobenzaldehyde
16588-34-4
|
1KG | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-Chloro-3-nitrobenzaldehyde
16588-34-4
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Chloro-3-nitrobenzaldehyde
16588-34-4
- $0.00
- 99.5%
- Honest Joy Holdings Limited
-
- 4-Chloro-3-nitrobenzaldehyde
16588-34-4
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
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