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DMT-dA(bz) Phosphoramidite

DMT-dA(bz) Phosphoramidite structure

CAS No.: 98796-53-3

Chemical Name:: DMT-dA(bz) Phosphoramidite

Synonyms: DMT-dA(Bz)-CE Phosphoramidite;DA-CE PHOSPHORAMIDITE;DMT-dA(bz) PhosphoraMidite;DMT-dA(Bz)-CE;DMT-dA(bz) AMidite;Bz-dA Phosphoramidite;DMT-dA(bz) Pharmadite;DNA A PHOSPHORAMIDITE;DMT-dA(Bz)-CE Amidites;DMT-dA-CEPhosphoramidite

CBNumber:: CB6127091

Molecular Formula:: C47H52N7O7P

Molecular Weight:: 857.93

MDL Number:: MFCD00036314

MOL File:: 98796-53-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:29:43

Product description	Number	Pack Size	Price
DMT-dA(bz) Phosphoramidite configured for MerMade	A111040	6x9.46g	$634
DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)	A111000	6x5g	$541
DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)	A111000	1kg	$14820
DMT-dA(bz) Phosphoramidite configured for MerMade	A111040	6x19.3g	$1550
DMT-dA(bz) Phosphoramidite	A111000	214.6g	$3660
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DMT-dA(bz) Phosphoramidite Properties

Density	1.23 at 20℃
vapor pressure	0-0Pa at 20-50℃
storage temp.	Sealed in dry,2-8°C
solubility	soluble, clear
form	powder or granules
pka	7.87±0.43(Predicted)
color	white to off-white
biological source	non-animal source (no BSE/TSE risk)
Water Solubility	soluble, clear
InChIKey	GGDNKEQZFSTIMJ-AKWFTNRHSA-N
SMILES	O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC(=O)C3=CC=CC=C3)N=C2)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N
LogP	7.14 at 20℃
UNSPSC Code	41116107
NACRES	NA.51

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P261-P280-P305+P351+P338
WGK Germany	3
HS Code	29349990
Storage Class	11 - Combustible Solids
REACH Registrations	Active

DMT-dA(bz) Phosphoramidite price More Price(99)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A111040	DMT-dA(bz) Phosphoramidite configured for MerMade	98796-53-3	6x9.46g	$634	2026-04-30	Buy
Sigma-Aldrich	A111000	DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)	98796-53-3	6x5g	$541	2026-04-30	Buy
Sigma-Aldrich	A111000	DMT-dA(bz) Phosphoramidite ≥99% (31P-NMR)	98796-53-3	1kg	$14820	2026-04-30	Buy
Sigma-Aldrich	A111040	DMT-dA(bz) Phosphoramidite configured for MerMade	98796-53-3	6x19.3g	$1550	2025-07-31	Buy
Sigma-Aldrich	A111000	DMT-dA(bz) Phosphoramidite	98796-53-3	214.6g	$3660	2025-07-31	Buy

Product number	Packaging	Price	Buy
A111040	6x9.46g	$634	Buy
A111000	6x5g	$541	Buy
A111000	1kg	$14820	Buy
A111040	6x19.3g	$1550	Buy
A111000	214.6g	$3660	Buy

DMT-dA(bz) Phosphoramidite Chemical Properties,Uses,Production

Physical form

Powder or granules

Color

White to off-white

General Description

DMT-dA(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites. Its key features include:
Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib)).
Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides.
The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides.

Uses

N6-Benzoyl-2’-deoxy-5’-O-DMT-cytidine 3’-CE Phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Synthesis

Phosphorodiamidous acid, N,N'-bis(1-methylethyl)-, 2-cyanoethyl ester

131420-63-8

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

64325-78-6

98796-53-3

Synthesis of (2R,3S,5R)-5-(6-benzoylamino-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide from N-(9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4- hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide: The general procedure for synthesizing (2R,3S,5R)-5-(6-benzoylamino-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl) Methoxy)methyl)tetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite was carried out in the following general steps: the nucleoside was phosphorylated using the N-methylimidazole salts of [O-β-cyanoethyl-N,N,N',N'-tetraisopropylphosphoramidite] and saccharin as the activators. This was done as follows: nucleoside (1.5 mmol) was added in a flask of appropriate size and the solid was dried by azeotropic distillation twice (using a rotary evaporator) with 20 mL of pyridine. After purging the flask with argon, 15 mL of acetonitrile was added. The mixture was stirred at room temperature until a clarified solution was formed. Subsequently, [O-β-cyanoethyl-N,N,N',N'-tetraisopropylphosphoramidite] (Tetraphos) was added to the solution, followed by the N-methylimidazole salt of saccharin. The reaction mixture was stirred continuously at room temperature and the progress of the reaction was monitored by HPLC. Upon completion of the reaction, the mixture was diluted with 30 mL of ethyl acetate and the organic phase was washed sequentially with 2 x 25 mL of saturated aqueous sodium bicarbonate and 25 mL of saturated aqueous sodium chloride. The organic layer was separated and dried with anhydrous magnesium sulfate. The dried suspension was filtered and the solvent was removed using a rotary evaporator. Finally, the residue was dried under vacuum to obtain the target product as a foamy solid.

References

[1] Patent: WO2004/35599, 2004, A1. Location in patent: Page 9-10
[2] Patent: WO2004/35599, 2004, A1. Location in patent: Page 10-11

DMT-dA(bz) Phosphoramidite synthesis

Synthesis of DMT-dA(bz) Phosphoramidite from 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite and N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

DMT-dA(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite Phosphorodiamidous acid, N,N'-bis(1-methylethyl)-, 2-cyanoethyl ester N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

Preparation Products

N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

DMT-dA(bz) Phosphoramidite Suppliers

Global( 220)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang Hengkang Pharmaceutical Co., Ltd.	+86-576-83372028 +86-18868723926	bd1@hengkangpharm.cn	China	119	58
INNOBIO PHARM CO.,LTD	+8615600141006	cindyyb@126.com	China	279	58
NewCan Biotech Limited	+86-571-86912261 19975279805	sales@newcanbio.com	China	9985	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Zhejiang Hengkang Pharmaceutical Co., Ltd.	58
INNOBIO PHARM CO.,LTD	58
NewCan Biotech Limited	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Yunbio Tech Co.,Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58

View Lastest Price from DMT-dA(bz) Phosphoramidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	DMT-dA(bz) Phosphoramidite 98796-53-3		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-08-08	DMT-dA(Bz)-CE 98796-53-3		10g	≥99%	20tons	Hefei Huana Biomedical Technology Co.,Ltd.
2024-02-13	Dmt-da(bz) phosphoramidite 98796-53-3	$1000.00	1g	95	500 Kg	R&D Scientific Inc.

DMT-dA(bz) Phosphoramidite
98796-53-3
98%
Henan Aochuang Chemical Co.,Ltd.

DMT-dA(Bz)-CE
98796-53-3
$0.00
≥99%
Hefei Huana Biomedical Technology Co.,Ltd.

Dmt-da(bz) phosphoramidite
98796-53-3
$1000.00
95
R&D Scientific Inc.

DMT-dA(bz) Phosphoramidite Spectrum

DMT-dA(bz) Phosphoramidite(98796-53-3)¹HNMR DMT-dA(bz) Phosphoramidite(98796-53-3)¹HNMR DMT-dA(bz) Phosphoramidite(98796-53-3)³¹PNMR DMT-dA(bz) Phosphoramidite(98796-53-3)¹³CNMR

98796-53-3(DMT-dA(bz) Phosphoramidite)Related Search:

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Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) ADENOSINE 5'-TRIPHOSPHATASE 3-Chloropropyltriethoxysilane 2'-Deoxyadenosine monohydrate Cyclic AMP

Benzoyl chloride Adenosine 2'-Deoxyadenosine 5'-Deoxyadenosylcobalamin 3-Aminopropyltriethoxysilane

DMT-2'O-TBDMS-rA(bz) Phosphoramidite N6-Benzoyl-2'-deoxyadenosine 5'-O-FDMT-N6-BENZOYL-2'-DEOXYADENOSINE CEP

1of4

N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine 5'-CE phosphoramidite N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-CE phosphoramidite 2'DEOXYADENOSINE PHOSPHORAMADITE 2'-DEOXYADENOSINE PHOSPHORAMIDITE dA(N-Bz) Phosphoramidite N-blocked-5'-O-DMT 3'-CED deoxyadenosine phosphoramidite (2R,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite REF DUPL: dA(bz) Phosphoramidite Bz-dA Phosphoramidite DMT-dA(bz) AMidite N⁶-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-CE phosphoraMidite 3'-O-P-5'-O-DMT-N-BZ-2'-DEOXY-ADENOSINE [DA(BZ) PHOSPHORAMIDITE] 5'-Dimethoxytrityl-N-benzoyl-2'-deoxyAdenosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite DMT-dA-CEPhosphoramidite N6-Benzoyl-5'-O-DMT-2'-deoxyadenosine-3'-CE Phosphoramidite N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-cyanoethyl Phosphoramidite N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite] 5'-O-DMT-N6-Benzyoyl-2'-Deoxy Adenosine Phosphoramidite N6-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE Phosphoramidite DMT-dA(bz) Pharmadite DNA A PHOSPHORAMIDITE N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-adenosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYADENOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE DMT-DA(BZ) AMIDITE 10G SINGLE DMT-DA(BZ) AMIDITE 2G AB 12 PACK DMT-dA(bz) Amidite, 5g, 6pack DMT-dA(bz) Amidite 1g, 89, 12 Pack DMT-dA(bz) Amidite 8.05g, 6 Pack DMT-dA(bz) Amidite 2g, 89, 12 Pack DMT-dA(bz) Amidite 1g, 60ml vial, 12 Pac DMT-dA(bz) Amidite 20g, 6 Pack DMT-DA(BZ) AMIDITE 5G SINGLE DMT-dA(bz) Amidite 2g, 60ml vial, 12 Pac DMT-DA(BZ) AMIDITE 4G 60ML VIAL 12 PAC DMT-DA(BZ) AMIDITE 1G AB 12 PACK 5'-O-DMT-N6-Benzoyl-2'-deoxyadenosine 3'-CE phosphoramidite deoxyadenosine-ce phosphoramidite for cyclone -(2-cyanoethyl-N,N-diisopropyl)phosphoramidite N6-benzoyl-DMT-2'-deoxyadenosine-3'-CE Phosphoramidite Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] DMT-Bz-dA phosphoramidite 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP 5'-DMT-Bz-dA phosphoramidite N6-Benzoyl-5'-O-DMT-2’-dA-3'-CE Phosphoramidite (2R,3S,5S)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxy phenyl)(phenyl)methoxy)methyl)-tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite N6-Benzoyl-2’-deoxy-5’-O-dimethoxytrityladenosine-3’-O-diisopropylaminocyanoethylphosphoramidite 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite DMT-dA(bz) PhosphoraMidite 5'-O-DMT-dA(BZ)-CE-Phosphoramidite 5'-O-DMT-N6-Benzoyl-2'-Deoxyadenosine-CE Phosphoramidite DMT-dA(Bz)-CE N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide dA(Bz) CE Phosphoramidite 5'-O-DMT-N6-Benzoyl-2'-Deoxy Adenosine-3’-Cyanoethyl Phosphoramidite deoxy N-Bz Adenosine Amidite DMT-dA(Bz)-CE Amidites N6-Benzoyl-5’-O-(4, 4’-dimethoxytrityl)-2’-deoxyadenosine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite DMT-dA (bz) Phosphorous Amide

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