2,4-Dichloro-5-methylpyrimidine
- CAS No.
- 1780-31-0
- Chemical Name:
- 2,4-Dichloro-5-methylpyrimidine
- Synonyms
- 4-Dichloro-5-MethylpyriMidine;NSC 37532;Toxic,stench;2,4-Dichloro-5-;2,4-Dichloro-5-methy;Dichloro-5-MethylpyriMid;2,4-Dichloro-5-Methylpyri...;5-Methyl-2,4-dichloropyrimidine;2,4-DICHLORO-5-METHYLPYRIMIDINE;2,4-dichloro-5-methyl-pyrimidin
- CBNumber:
- CB6130202
- Molecular Formula:
- C5H4Cl2N2
- Molecular Weight:
- 163
- MDL Number:
- MFCD00023197
- MOL File:
- 1780-31-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2,4-Dichloro-5-methylpyrimidine 98% | D66182 | 5g | $120 |
| 2,4-Dichloro-5-methylpyrimidine 98% | D66182 | 1g | $34.4 |
| 2,4-Dichloro-5-methylpyrimidine >98.0%(GC) | D3613 | 1g | $20 |
| 2,4-Dichloro-5-methylpyrimidine >98.0%(GC) | D3613 | 5g | $38 |
| 2,4-Dichloro-5-methylpyrimidine|**Toxic, Stench** | D3531-30 | 5g | $425 |
| More product size | |||
| Melting point | 26-28 °C (lit.) |
|---|---|
| Boiling point | 108-109 °C/11 mmHg (lit.) |
| Density | 1.39 g/mL at 25 °C (lit.) |
| refractive index | 1.6300 (estimate) |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in chloroform, ether, ethyl acetate and toluene |
| pka | -2.44±0.29(Predicted) |
| form | powder to lump to clear liquid |
| color | White or Colorless to Almost white or Almost colorless |
| Sensitive | Lachrymatory |
| InChI | InChI=1S/C5H4Cl2N2/c1-3-2-8-5(7)9-4(3)6/h2H,1H3 |
| InChIKey | DQXNTSXKIUZJJS-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(C)C(Cl)=N1 |
| CAS DataBase Reference | 1780-31-0(CAS DataBase Reference) |
| FDA UNII | G2W3V2TE7S |
| EPA Substance Registry System | Pyrimidine, 2,4-dichloro-5-methyl- (1780-31-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
2,4-Dichloro-5-methylpyrimidine price More Price(81)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D66182 | 2,4-Dichloro-5-methylpyrimidine 98% | 1780-31-0 | 5g | $120 | 2026-04-30 | Buy |
| Sigma-Aldrich | D66182 | 2,4-Dichloro-5-methylpyrimidine 98% | 1780-31-0 | 1g | $34.4 | 2023-06-20 | Buy |
| TCI Chemical | D3613 | 2,4-Dichloro-5-methylpyrimidine >98.0%(GC) | 1780-31-0 | 1g | $20 | 2026-04-30 | Buy |
| TCI Chemical | D3613 | 2,4-Dichloro-5-methylpyrimidine >98.0%(GC) | 1780-31-0 | 5g | $38 | 2026-04-30 | Buy |
| Usbiological | D3531-30 | 2,4-Dichloro-5-methylpyrimidine|**Toxic, Stench** | 5g | $425 | 2026-06-03 | Buy |
2,4-Dichloro-5-methylpyrimidine Chemical Properties,Uses,Production
Chemical Properties
White to Off White Low Melting Solid
Uses
2,4-Dichloro-5-methylpyrimidine, is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine. It can react with piperidineto produce 2-chloro-5-methyl-4-piperidin-1-yl-pyrimidine. This reaction will need solvent dioxane.
Synthesis
65-71-4
1780-31-0
General procedure for the synthesis of 2,4-dichloro-5-methylpyrimidine from 5-methyluracil: 5-methyluracil (1 g, 7.93 mmol) was added to phosphorochloridic acid (7 eq., 5 ml), and the mixture was heated and refluxed for 3 hours. After completion of the reaction, the mixture was slowly poured into ice water to quench the reaction. The organic layer was extracted with chloroform (3 x 20 ml), the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 2,4-dichloro-5-methylpyrimidine as yellow crystals (0.62 g, 48% yield). The structure of the product was confirmed by nuclear magnetic resonance hydrogen (1H NMR, 400 MHz, CDCl3) and carbon (13C NMR, 100 MHz, CDCl3) spectra: 1H NMR δ 8.35 (s, 1H), 2.39 (s, 3H); 13C NMR δ 162.5, 160.0, 158.2, 129.1, 15.8. The data obtained were in agreement with those of literature reports (Wang et al., Molecules, 2012, 17(4), 4533-4544).
References
[1] Journal of Fluorine Chemistry, 1996, vol. 77, # 1, p. 93 - 95
[2] Patent: WO2018/151681, 2018, A1. Location in patent: Paragraph 0099
[3] Synthetic Communications, 1992, vol. 22, # 20, p. 2927 - 2934
[4] Tetrahedron Letters, 1997, vol. 38, # 7, p. 1111 - 1114
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 18, p. 2961 - 2966
2,4-Dichloro-5-methylpyrimidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang TYSChem Co., Ltd. | +86-24-83607930 +8618640359690 | sales@honghuchem.com | China | 403 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
View Lastest Price from 2,4-Dichloro-5-methylpyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-01 | 2,4-Dichloro-5-methylpyrimidine
1780-31-0
|
1KG | 99.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-11-18 | 2,4-Dichloro-5-methylpyrimidine
1780-31-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-09-25 | 2,4-Dichloro-5-methylpyrimidine
1780-31-0
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd |
-
- 2,4-Dichloro-5-methylpyrimidine
1780-31-0
- 99.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,4-Dichloro-5-methylpyrimidine
1780-31-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,4-Dichloro-5-methylpyrimidine
1780-31-0
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
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