1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
- CAS No.
- 161491-24-3
- Chemical Name:
- 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
- Synonyms
- Methyl N-Boc-4-piperidone-3-carboxylate;1-Boc-4-oxo-3-piperidine carboxylic acid Methyl ester;methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate;1-O-tert-butyl 3-O-methyl 4-oxopiperidine-1,3-dicarboxylate;N-BOC-3-carbomethoxy-4-piperidone;1-tert-Butyl 3-methyl 4-oxopiperidine-;Methyl N-BOC-4-piperidine-3-carboxylate;Methyl 1-BOC-4-oxopiperidine-3-carboxylate;METHYL N-BOC-4-OXOPIPERIDINE-3-CARBOXYLATE;Methyl1-N-Boc4-oxopiperidine-3-carboxylate
- CBNumber:
- CB61501216
- Molecular Formula:
- C12H19NO5
- Molecular Weight:
- 257.28
- MDL Number:
- MFCD08752608
- MOL File:
- 161491-24-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-tert-Butyl 3-Methyl 4-Oxopiperidine-1,3-dicarboxylate | M3338 | 5G | $33 |
| 1-tert-Butyl 3-Methyl 4-Oxopiperidine-1,3-dicarboxylate | M3338 | 25G | $101 |
| 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Asreported | 263847 | 500mg | $389 |
| 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Asreported | 263847 | 1g | $556 |
| 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Asreported | 263847 | 2g | $805 |
| More product size | |||
| Melting point | 32-34 °C |
|---|---|
| Boiling point | 350.0±42.0 °C(Predicted) |
| Density | 1.175±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 11.06±0.20(Predicted) |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C12H19NO5/c1-12(2,3)18-11(16)13-6-5-9(14)8(7-13)10(15)17-4/h8H,5-7H2,1-4H3 |
| InChIKey | HBWUTYLVFYVXML-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(=O)C(C(OC)=O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933399990 |
1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3338 | 1-tert-Butyl 3-Methyl 4-Oxopiperidine-1,3-dicarboxylate | 161491-24-3 | 5G | $33 | 2026-04-30 | Buy |
| TCI Chemical | M3338 | 1-tert-Butyl 3-Methyl 4-Oxopiperidine-1,3-dicarboxylate | 161491-24-3 | 25G | $101 | 2026-04-30 | Buy |
| Usbiological | 263847 | 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Asreported | 161491-24-3 | 500mg | $389 | 2026-06-03 | Buy |
| Usbiological | 263847 | 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Asreported | 161491-24-3 | 1g | $556 | 2026-06-03 | Buy |
| Usbiological | 263847 | 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Asreported | 161491-24-3 | 2g | $805 | 2026-06-03 | Buy |
1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Chemical Properties,Uses,Production
Application
1-tert-butyl 4-oxopiperidinium-1,3-dicarboxylic acid ester and 3-methyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
Chemical Properties
White to Light yellow powder to crystal
Synthesis
79099-07-3
616-38-6
161491-24-3
60% sodium hydride (3.5 g, 88 mmol) was suspended in anhydrous toluene (50 mL) at room temperature and protected by nitrogen. Dimethyl carbonate (4.32 g, 48.0 mmol) was added slowly and dropwise to this suspension over a period of 0.5 hours. After the addition of a few drops of methanol, a solution of N-tert-butoxycarbonyl-4-piperidone (4.8 g, 24 mmol) dissolved in anhydrous toluene (20 mL) was added dropwise to the reaction mixture while maintaining the reaction system at 80 °C with stirring. The reaction mixture was continued to be stirred at the same temperature for 3 h. The reaction mixture was subsequently cooled to 0 °C (ice bath) and the pH was adjusted to 6-6.5 with acetic acid. the resulting cold mixture was diluted with water (10 mL) and the pH was adjusted to 8 with 5% sodium hydroxide solution. the toluene layer was separated and the aqueous layer was extracted with toluene (20 mL). The combined organic layers were dried with anhydrous sodium sulfate and concentrated under reduced pressure. The product was dried under vacuum to afford methyl methyl-1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate (5.0 g, 80% yield). The resulting compound did not require further purification and could be used directly in the subsequent reaction.
References
[1] European Journal of Medicinal Chemistry, 2009, vol. 44, # 10, p. 4063 - 4069
[2] Patent: WO2016/123571, 2016, A1. Location in patent: Paragraph 00265
[3] Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13271 - 13280
[4] Journal of the American Chemical Society, 2015, vol. 137, # 21, p. 6738 - 6741
[5] Patent: CN107163045, 2017, A. Location in patent: Paragraph 0037; 0038
1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| AB PharmaTech,LLC | 323-480-4688 | sales@acrospharmatech.com | United States | 989 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
View Lastest Price from 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | Methyl N-Boc-4-piperidone-3-carboxylate
161491-24-3
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2024-07-06 | 1-(tert-butyl) 3-methyl 4-oxopiperidine -1,3-dicarboxylate
161491-24-3
|
$300.00 | 1kg | 98% | 2mt/month | Sach biotech Co.,Ltd | |
 |
2019-08-06 | 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
161491-24-3
|
$1.00 | 1KG | 98% | 10KG | Career Henan Chemical Co |
-
- Methyl N-Boc-4-piperidone-3-carboxylate
161491-24-3
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 1-(tert-butyl) 3-methyl 4-oxopiperidine -1,3-dicarboxylate
161491-24-3
- $300.00
- 98%
- Sach biotech Co.,Ltd
-
- 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
161491-24-3
- $1.00
- 98%
- Career Henan Chemical Co
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