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cis-4-Hydroxy-L-proline

cis-4-Hydroxy-L-proline structure

CAS No.: 618-27-9

Chemical Name:: cis-4-Hydroxy-L-proline

Synonyms: (2S,4S)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;H-CIS-HYP-OH;CIS-4-HYDROXYPROLINE;CIS-HYP-OH;CIS-HYDROXYPROLINE;cis-Hydroxy-L-proline;(4S)-4-hydroxypyrrolidine-2-carboxylic acid;CHYP;cis L;cis-L-Hyp-OH

CBNumber:: CB6158895

Molecular Formula:: C5H9NO3

Molecular Weight:: 131.13

MDL Number:: MFCD00064319

MOL File:: 618-27-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:59:16

Product description	Number	Pack Size	Price
cis-4-Hydroxy-L-proline collagen synthesis inhibitor	H1637	50mg	$90.5
cis-4-Hydroxy-L-proline collagen synthesis inhibitor	H1637	1g	$756
cis-4-Hydroxy-L-proline >97.0%(T)	H1169	100mg	$61
cis-4-Hydroxy-L-proline >97.0%(T)	H1169	1g	$294
cis-4-Hydroxy-L-proline	279716	1g	$312
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cis-4-Hydroxy-L-proline Properties

Melting point	257 °C (dec.) (lit.)
alpha	-59 º (c=2, H2O)
Boiling point	242.42°C (rough estimate)
Density	1.3121 (rough estimate)
refractive index	-59 ° (C=2, H2O)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble
form	Powder
pka	2.14±0.40(Predicted)
color	White to beige
Water Solubility	soluble
Merck	14,4840
BRN	81440
Major Application	peptide synthesis
InChI	1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1
InChIKey	PMMYEEVYMWASQN-IMJSIDKUSA-N
SMILES	O[C@@H]1CN[C@@H](C1)C(O)=O
CAS DataBase Reference	618-27-9(CAS DataBase Reference)
FDA UNII	43V78B6A3B
EPA Substance Registry System	L-Proline, 4-hydroxy-, (4S)- (618-27-9)
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

24/25-36/37/39-27-26

WGK Germany

TSCA

TSCA listed

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
1		0

cis-4-Hydroxy-L-proline price More Price(117)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H1637	cis-4-Hydroxy-L-proline collagen synthesis inhibitor	618-27-9	50mg	$90.5	2026-04-30	Buy
Sigma-Aldrich	H1637	cis-4-Hydroxy-L-proline collagen synthesis inhibitor	618-27-9	1g	$756	2025-07-31	Buy
TCI Chemical	H1169	cis-4-Hydroxy-L-proline >97.0%(T)	618-27-9	100mg	$61	2026-04-30	Buy
TCI Chemical	H1169	cis-4-Hydroxy-L-proline >97.0%(T)	618-27-9	1g	$294	2026-04-30	Buy
Usbiological	279716	cis-4-Hydroxy-L-proline	618-27-9	1g	$312	2026-06-03	Buy

Product number	Packaging	Price	Buy
H1637	50mg	$90.5	Buy
H1637	1g	$756	Buy
H1169	100mg	$61	Buy
H1169	1g	$294	Buy
279716	1g	$312	Buy

cis-4-Hydroxy-L-proline Chemical Properties,Uses,Production

Chemical Properties

White to beige powder

Uses

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line DSL6A.

Uses

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

Uses

Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

Definition

ChEBI: L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).

Biochem/physiol Actions

cis-4-Hydroxy-L-proline (CHP) and its derivatives may have anticancer activity. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

in vivo

cis-4-Hydroxy-L-proline (285-903 mg/kg; p.o.; 28 days) causes signs of liver damage in rats, showing elevated alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT)^[3].
cis-4-Hydroxy-L-proline (200 mg/kg; s.c.; twice daily; 30 days) partially prevents the accumulation of collagen in the lungs and partially improves the decrease in lung compliance in the Bleomycin (HY-108345)-induced pulmonary fibrosis model experiment of hamsters^[4].
cis-4-Hydroxy-L-proline (200 mg/kg; s.c.; injected alone for 3 days first and then co-injected with dihydrotestosterone for 10 days) significantly reduces the wet weight of the prostate, inhibits the proliferation and differentiation of prostatic glandular cells in response to androgen stimulation in Androgen-induced prostate growth model in prepubertal castrated guinea pigs^[5].
CHOP-PEG (polymeric prodrug of cis-4-Hydroxy-L-proline, 0.8 mg by continuous s.c.; 10 mg by single s.c.; 40 mg by single i.v.; 90 mg by single intratracheal injection; 7 days) can prevent and reverse chronic hypoxic pulmonary hypertension in the rat hypoxic pulmonary hypertension model^[6].

Animal Model:	Rats^[3]
Dosage:	285 mg/kg, 507 mg/kg, 903 mg/kg
Administration:	Oral gavage (p.o.), 28 days
Result:	Increased ALAT and ASAT at a dose of 903 mg/kg. Increased albumin at 507 mg/kg. Increased blood urea nitrogen at 903 mg/kg CHP. Revealed a pale appearance of the liver due to drug-induced anemia.

cis-4-Hydroxy-L-proline synthesis

Synthesis of cis-4-Hydroxy-L-proline from Z-CIS-HYP-OH

cis-4-Hydroxy-L-proline Preparation Products And Raw materials

Raw materials

L-Proline, 4-hydroxy-, ethyl ester, (4S)- (9CI) 1,2-Pyrrolidinedicarboxylic acid, 4-(formyloxy)-, 2-methyl 1-(phenylmethyl) ester, (2S-cis)- (9CI) N-Boc-cis-4-Hydroxy-L-proline （2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine N-Cbz-Hydroxy-L-proline

Z-CIS-HYP-OH （2s，4s）-dibenzyl 4-hydroxypyrrolidine-1，2-dicarboxylate Z-HYP-OME L-Hydroxyproline

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Preparation Products

Fomc-cis-L-hydroxyproline-OH 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

cis-4-Hydroxy-L-proline Suppliers

Global( 364)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Chengdu Pukang Biotechnology Co., Ltd	028-82550498	export@pu-kang.com	CHINA	210	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58
Shanghai Longyu Biotechnology Co., Ltd.		info@longyupharma.com	China	2430	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Chembon Pharmaceutical Co., Ltd.	55
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Chengdu Pukang Biotechnology Co., Ltd	58
Changzhou Ditong Chemical Co.,Ltd	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from cis-4-Hydroxy-L-proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-11	cis-4-Hydroxy-L-proline 618-27-9	$33.00-55.00		99.88%	10g	TargetMol Chemicals Inc.
2025-04-04	cis-4-Hydroxy-L-proline 618-27-9		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2022-02-22	(2S,4S)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid 618-27-9		1KG	97.9%	100 tons	Honest Joy Holdings Limited

cis-4-Hydroxy-L-proline
618-27-9
$33.00-55.00
99.88%
TargetMol Chemicals Inc.

cis-4-Hydroxy-L-proline
618-27-9
98%
Henan Aochuang Chemical Co.,Ltd.

(2S,4S)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid
618-27-9
$0.00
97.9%
Honest Joy Holdings Limited

cis-4-Hydroxy-L-proline Spectrum

cis-4-Hydroxy-L-proline(618-27-9)MS cis-4-Hydroxy-L-proline(618-27-9)¹HNMR cis-4-Hydroxy-L-proline(618-27-9)¹³CNMR cis-4-Hydroxy-L-proline(618-27-9)IR1 cis-4-Hydroxy-L-proline(618-27-9)IR2 cis-4-Hydroxy-L-proline(618-27-9)Raman

618-27-9(cis-4-Hydroxy-L-proline)Related Search:

CIS-4-HYDROXY-L-PROLINE METHYL ESTER HCL,CIS-4-HYDROXY-L-PROLINE METHYL ESTER HYDROCHLORIDE D-Proline L-PROLINE-(4-3H(N)) L-Proline CHLOROPHOSPHONAZO III

cis-4-Hydroxy-D-proline hydrochloride,CIS-4-HYDROXY-D-PROLINE HCL CIS-4-HYDROXY-D-PROLINE (4S)-4-hydroxy-L-proline hydrochloride cis-4-Hydroxycyclohexanecarboxylic acid Cyclohexanecarboxylic acid, 4-hydroxy-, Methyl ester, cis-

cis-4-Methoxy-cyclohexylamine hydrochloride cis-4-AMinocyclohexaneMethanol hydrochloride 4-(Dimethylamino)cyclohexanol CIS-4-HYDROXY-D-PROLINE METHYL ESTER L-Hydroxyproline

N-Boc-cis-4-Hydroxy-L-proline methyl ester N-ALPHA-BUTOXYCARBONYL-CIS-4-HYDROXY-L-PROLINE,N-BOC-CIS-4-HYDROXY-L-PROLINE,N-T-BOC-CIS-4-HYDROXY-L-PROLINE,BOC-CIS-4-HYDROXY-L-PROLINE N-Cbz-Hydroxy-L-proline

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(S)-Allo-hydroxyproline cis-4-Hydroxy-L-proline collagen synthesis inhibitor L-ALLO-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID L-ALLO-4-HYDROXY-2-PYRROLIDINECARBOXYLLIC ACID L-ALLO-HYDROXYPROLINE CIS-4-HYDROXY-L-PROLINE CIS-L-4-HYDROXYPROLINE CHYP HYDROXY-L-PROLINE [ALLO] H-PRO(CIS-4-OH)-OH H-L-CIS-HYP-OH cis-4-Hydroxy-L-proline, 97.0%(T) cis-L-4-Hydroxyproline≥ 99% (NMR) cis-L-Hyp-OH cis-4-Hydroxy-L-proline Hydrochloride,99%e.e. cis-4-Hydroxy-L-proline Vetec(TM) reagent grade, 98% CIS-4-HYDROXY-L-PROLINE HYDROLORIDE L-CIS-4-HYDROXYPROLINE L-CIS-HYDROXYPROLINE (2S,4S)-(-)-4-HYDROXY-2-PYRROLINECARBOXYLIC ACID ALLO-4-HYDROXY-L-PROLINE cis-4-L-Hydroxyproline (2S,4S)-(-)-4-Hydroxypyrrolidin-2-ylcarboxylic acid CIS-4-HYDROXY-L-PROLINE NATURAL ISOMER -ALLO-HYDROXYPROLINE 4-CIS-HYDROXYPROLINE L-CIS-HYDROXYPROLINE, (2S,4S)-(-)-4-HYDROXY-2-PYRROLINECARBOXYLIC ACID (2S,4S)-4-HYDROXY-L-PROLINE (2S)-4α-Hydroxy-2α-pyrrolidinecarboxylic acid (4S)-4-Hydroxy-L-proline cis-4-Hydroxy-L-proline,99% Cis-4-Hydroxy-L-proline methyl ester (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride Cis-4-hydroxy-L-proline Hyadrochloride (2S,4S)-4-Hydroxyproline (2S,4S)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid 97% cis-4-Hydroxy-L-proline USP/EP/BP L-Proline, 4-hydroxy-, (4S)- cis-4-Hydroxy-L cis-4-Hydroxy-L-proline> cis L (4S)-4-hydroxypyrrolidine-2-carboxylic acid cis-Hydroxy-L-proline proline,collagen,Inhibitor,cis4HydroxyLproline,tumor,cis 4 Hydroxy L proline,inhibit,Endogenous Metabolite,fibroblast Coclaurine Impurity 4 (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid/cis-4-Hydroxy-L-proline cis-4-Hydroxy-L-proline (2S,4S)-cis-4-hydroxy-L-proline (2S,4S)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID CIS-HYDROXYPROLINE CIS-HYP-OH CIS-4-HYDROXYPROLINE H-CIS-HYP-OH 618-27-9 618-21-7 Specialty Synthesis Proline Derivatives Peptide Synthesis

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cis-4-Hydroxy-L-proline

cis-4-Hydroxy-L-proline Properties

SAFETY

Risk and Safety Statements

cis-4-Hydroxy-L-proline price More Price(117)

cis-4-Hydroxy-L-proline Chemical Properties,Uses,Production

Chemical Properties

Uses

Uses

Uses

Definition

Biochem/physiol Actions

in vivo

cis-4-Hydroxy-L-proline synthesis

cis-4-Hydroxy-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

cis-4-Hydroxy-L-proline Suppliers

View Lastest Price from cis-4-Hydroxy-L-proline manufacturers

cis-4-Hydroxy-L-proline Spectrum

618-27-9(cis-4-Hydroxy-L-proline)Related Search: