3-AMINOPHTHALIC ACID HYDROCHLORIDE
- CAS No.
- 6946-22-1
- Chemical Name:
- 3-AMINOPHTHALIC ACID HYDROCHLORIDE
- Synonyms
- 3-Aminophthalic acid HCL;3-amino-hydrochloride;Pomalidomide Impurity 5;3-AMINOPHTHALIC ACID HYDR;Pomalidomide Impurity A HCl;Pomalidomide Impurity 22 HCl;3-AminophthalicacidHClhydrate;3-Aminophthalsurehydrochlorid;3-aminophthalic acid chloride;3-AMINOPHTHALIC ACID HYDROCHLORIDE
- CBNumber:
- CB6183187
- Molecular Formula:
- C8H8ClNO4
- Molecular Weight:
- 217.61
- MDL Number:
- MFCD00017644
- MOL File:
- 6946-22-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Aminophthalic Acid Hydrochloride | TRC-A627715-5G | 5g | $108 |
| 3-Aminophthalic Acid Hydrochloride | TRC-A627715-500MG | 500mg | $63 |
| 3-Aminophthalic Acid Hydrochloride | TRC-A627715-1G | 1g | $75 |
| 3-Aminophthalic acid hydrochloride | FA29862 | 0.25kg | $150 |
| 3-Aminophthalic acid hydrochloride | FA29862 | 0.5kg | $162.25 |
| More product size | |||
| Melting point | 182 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Very Slightly) |
| form | Crystalline Powder |
| color | Off-white to yellow-beige |
| Stability | Hygroscopic |
| InChI | InChI=1S/C8H7NO4.ClH/c9-5-3-1-2-4(7(10)11)6(5)8(12)13;/h1-3H,9H2,(H,10,11)(H,12,13);1H |
| InChIKey | ZBZAVEORKXFUQB-UHFFFAOYSA-N |
| SMILES | C1(C(=O)O)C(N)=CC=CC=1C(=O)O.Cl |
| CAS DataBase Reference | 6946-22-1(CAS DataBase Reference) |
| EPA Substance Registry System | 1,2-Benzenedicarboxylic acid, 3-amino-, hydrochloride (6946-22-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 24/25 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29242998 | |||||||||
| NFPA 704 |
|
3-AMINOPHTHALIC ACID HYDROCHLORIDE price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-A627715-5G | 3-Aminophthalic Acid Hydrochloride | 6946-22-1 | 5g | $108 | 2026-06-03 | Buy |
| TRC | TRC-A627715-500MG | 3-Aminophthalic Acid Hydrochloride | 6946-22-1 | 500mg | $63 | 2026-06-03 | Buy |
| TRC | TRC-A627715-1G | 3-Aminophthalic Acid Hydrochloride | 6946-22-1 | 1g | $75 | 2026-06-03 | Buy |
| Biosynth | FA29862 | 3-Aminophthalic acid hydrochloride | 6946-22-1 | 0.25kg | $150 | 2026-06-04 | Buy |
| Biosynth | FA29862 | 3-Aminophthalic acid hydrochloride | 6946-22-1 | 0.5kg | $162.25 | 2026-06-04 | Buy |
3-AMINOPHTHALIC ACID HYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
off-white to yellow-beige crystalline powder
Uses
3-Aminophthalic Acid Hydrochloride is a reactant used in the preparation of local anesthetics.
Synthesis
603-11-2
6946-22-1
The general procedure for the synthesis of 3-aminophthalic acid hydrochloride from 3-nitrophthalic acid was as follows: an ethanol solution (600 mL) of 3-nitrophthalic acid (100 g) and 10% Pd/C catalyst (3.2 g) was added to an autoclave. A hydrogen pressure of 4.0 kg was applied at 20-25 °C and the reaction was carried out for 3.0 hours. Upon completion of the reaction, the reaction mixture was cooled to 20 °C and filtered through a Hyflo bed. The filtrate was concentrated by distillation under reduced pressure and acetone was added to the residue. The mixture was cooled to 10 °C and concentrated hydrochloric acid was added slowly with continuous stirring. After removing the solvent under reduced pressure, acetonitrile was added. The mixture was again cooled to 10°C and the precipitated solid was filtered. Finally, the product was dried under vacuum at 45-50 °C for 6 h to give 3-aminophthalic acid hydrochloride (65.0 g).
References
[1] Patent: US5103057, 1992, A
[2] Patent: EP434145, 1991, A2
[3] Patent: WO2017/33116, 2017, A1. Location in patent: Paragraph 00114; 00132
[4] Patent: CN106986783, 2017, A. Location in patent: Paragraph 0008
3-AMINOPHTHALIC ACID HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
View Lastest Price from 3-AMINOPHTHALIC ACID HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-05 | 3-Aminophthalic acid hydrochloride
6946-22-1
|
$171.00 | 1kg | 98.0%min | 12tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2026-05-28 | 3-Aminophthalic Acid Hydrochloride Dihydrate
6946-22-1
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-01-04 | 3-Aminophthalic acid hydrochloride
6946-22-1
|
1kg | 99% | Hangzhou ICH Biofarm Co., Ltd |
-
- 3-Aminophthalic acid hydrochloride
6946-22-1
- $171.00
- 98.0%min
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 3-Aminophthalic Acid Hydrochloride Dihydrate
6946-22-1
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3-Aminophthalic acid hydrochloride
6946-22-1
- 99%
- Hangzhou ICH Biofarm Co., Ltd
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