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(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol structure

CAS No.: 14347-78-5

Chemical Name:: (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol

Synonyms: (R)-(-)-1,2-O-ISOPROPYLIDENEGLYCEROL;(R)-(-)-SOLKETAL;(R)-(-)-1,2-Isopropylideneglycerol;(R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL;(R)-2,2-DIMETHYL 4-HYDROXYMETHYL-1,3-DIOXOLANE;(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol, L-α,β-Isopropylideneglycerol;2,3-Isopropylidene-sn-glycerol, L-α,β-Isopropylideneglycerol, L-2,3-O-isopropylidene-sn-glycerol;R-Glycerol;ane-4-methanoL;R-(-)-Sollketal

CBNumber:: CB6184467

Molecular Formula:: C6H12O3

Molecular Weight:: 132.16

MDL Number:: MFCD00003213

MOL File:: 14347-78-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:16:12

Product description	Number	Pack Size	Price
(R)-(?)-2,2-Dimethyl-1,3-dioxolane-4-methanol 98%	241806	1g	$38.5
(R)-(?)-2,2-Dimethyl-1,3-dioxolane-4-methanol 98%	241806	5g	$80.8
(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol >97.0%(GC)	D1705	1g	$17
(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol >97.0%(GC)	D1705	5g	$39
(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol	TRC-D472630-10G	10g	$286
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(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Properties

alpha	-13.7 º (neat)
Boiling point	72-73 °C/8 mmHg (lit.)
Density	1.062 g/mL at 25 °C (lit.)
refractive index	n20/D 1.434
Flash point	176 °F
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	14.20±0.10(Predicted)
form	Liquid
color	Clear colorless to light yellow
Specific Gravity	1.062
optical activity	[α]20/D 13.7°, neat
Water Solubility	miscible
Merck	14,5213
BRN	80117
Stability	Stable. Incompatible with strong oxidizing agents.
InChI	1S/C6H12O3/c1-6(2)8-4-5(3-7)9-6/h5,7H,3-4H2,1-2H3/t5-/m1/s1
InChIKey	RNVYQYLELCKWAN-RXMQYKEDSA-N
SMILES	CC1(C)OC[C@@H](CO)O1
CAS DataBase Reference	14347-78-5(CAS DataBase Reference)
NIST Chemistry Reference	D-Acetone glycerol(14347-78-5)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H227

Precautionary statements

P210-P280-P370+P378-P403+P235-P501-P210e-P280a-P370+P378a-P501a

PPE

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Safety Statements

23-24/25

WGK Germany

RTECS

JI0400000

HS Code

29329990

Storage Class

10 - Combustible liquids

NFPA 704

	2
0		0

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	241806	(R)-(?)-2,2-Dimethyl-1,3-dioxolane-4-methanol 98%	14347-78-5	1g	$38.5	2026-04-30	Buy
Sigma-Aldrich	241806	(R)-(?)-2,2-Dimethyl-1,3-dioxolane-4-methanol 98%	14347-78-5	5g	$80.8	2026-04-30	Buy
TCI Chemical	D1705	(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol >97.0%(GC)	14347-78-5	1g	$17	2026-04-30	Buy
TCI Chemical	D1705	(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol >97.0%(GC)	14347-78-5	5g	$39	2026-04-30	Buy
TRC	TRC-D472630-10G	(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol	14347-78-5	10g	$286	2026-06-03	Buy

Product number	Packaging	Price	Buy
241806	1g	$38.5	Buy
241806	5g	$80.8	Buy
D1705	1g	$17	Buy
D1705	5g	$39	Buy
TRC-D472630-10G	10g	$286	Buy

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Chemical Properties,Uses,Production

Uses

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol is a MEK inhibitor with antitumor activity.

Chemical Properties

colourless liquid

Uses

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol may be used to prepare:

(R)-2,2-Dimethyl-4-benzoxymethyl-1,3-dioxolane.
((S)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate)-1,3-dioxolane.
(S)-Glyceraldehyde acetonide.
Tetraoxaspiroundecanes, diglycerides, glyceryl phosphates, and spiropyrans.

Uses

A MEK inhibitor

Synthesis

Using anhydrous zinc chloride as the catalyst, the condensation reaction of D-mannitol with acetone to synthesize the diisopropylidene condensate was carried out under the optimal reaction conditions, with a yield of up to 65%. Subsequently, (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol was obtained via chain cleavage by NaIO? oxidation and reduction with NaBH?.

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol synthesis

Synthesis of (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol from 2,2-Dimethyl-1,3-dioxolane-4-methanol

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Preparation Products And Raw materials

Raw materials

L(+)-Diethyl L-tartrate p-Toluenesulfonic acid Ethanol 1,2:5,6-Bis-O-(1-methylethylidene)-D-mannitol Acetone

Tetrabutylammonium bromide Sodium borohydride Tetrahydrofuran (2S,3S)(-)-Dihydroxybutane-1,4-dioic acid diethyl ester Ethyl acetate

Acetic acid Sodium periodate

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Preparation Products

[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanamine (2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE 2,2-DIMETHYL-4(S)-4-IODOMETHYL-1,3-DIOXALANE

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Suppliers

Global( 395)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	+86-531-88625728 +86-15806417970	sales@boyuanpharm.com	China	181	58
Nantong Provichem Biotech Co., Ltd.	+8617505220108	sales@provichem.cn	China	34	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5228	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2950	58

Supplier	Advantage
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	58
Nantong Provichem Biotech Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-03	(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol 14347-78-5	$10.00	1kg	≥98%	20 tons	Nantong Provichem Biotech Co., Ltd.
2026-05-28	(R) - (-) -2, 2-Dimethyl-1, 3-Dioxolane-4-Methanol 14347-78-5	$10.70	10KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-01-04	(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol 14347-78-5		1kg	99.0%min	5MT	Hangzhou ICH Biofarm Co., Ltd

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
14347-78-5
$10.00
≥98%
Nantong Provichem Biotech Co., Ltd.

(R) - (-) -2, 2-Dimethyl-1, 3-Dioxolane-4-Methanol
14347-78-5
$10.70
99%
Hebei Chuanghai Biotechnology Co,.LTD

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
14347-78-5
$0.00
99.0%min
Hangzhou ICH Biofarm Co., Ltd

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Spectrum

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol(14347-78-5)¹HNMR (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol(14347-78-5)IR (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol(14347-78-5)Raman

14347-78-5((R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol)Related Search:

Hydroxyacetone Glycerol Dimethyl ether Dimethyl carbonate Dimethyl fumarate

Dacthal Methanol 1,3-Dioxan-5-ol Dimethyl disulfide Diacetone Alcohol

Dimethyl sulfate ETHANE Dimethyl sulfoxide N,N-Dimethylformamide Nitroglycerin

Diacetonefructose 2,2-Dimethyl-1,3-dioxolane-4-methanol (+)-Taddol

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L-ALPHA,BETA-ISOPROPYLIDENEGLYCEROL L-2,3-O-ISOPROPYLIDENE-SN-GLYCEROL L-(-)-1,2-ISOPROPYLIDENEGLYCEROL 2,3-ISOPROPYLIDENE-SN-GLYCEROL 2,3-O-ISOPROPYLIDENE-L-GLYCEROL (-)-2,3-O-ISOPROPYLIDENE-SN-GLYCEROL R-GLYCEROL ACETONIDE R-(-)-2,3-O-ISOPROPYLIDENEGLYCEROL (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol, 95+% (2R)-1-O,2-O-Isopropylideneglycerol (4R)-2,2-Dimethyl-1,3-dioxolane-4α-methanol (4R)-2,2-Dimethyl-4-hydroxymethyl-1,3-dioxolane (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol,98% R-(-)-Sollketal (R)-(-)-2,2-Dimethyl-1,3-dioxlane-4-methanol (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol 98% (R)-2,3-ISOPROPYLIDENE GLYCEROL R-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-METHANOL ((R)-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-METHANOL R-(-)-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-METHANOL (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL (R)-(-)-2,2-DIMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE (R)-2,2-dimethyl-1,3-dioxalone-4-methanol L-Glycerol-acetonide (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLANE-4-MET HANOL, 98% (99% EE/GLC) Glycerol acetonide((R)-1,2-O-Isopropylideneglycerol) R-Glycerol 1,3-Dioxolane-4-methanol, 2,2-dimethyl-, (4R)- (R)-(-)-1,2-O-ISOPROPYLIDENEGLYCEROL (GLYCEROL ACETONIDE) (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL ((R)-(-)-SOLKETAL) L-a,b-Isopropylideneglycerol SOLKETAL A.K.A. (R)-O-ISOPROPYLIDENE GLYCEROL ISOPROPYLIDENEGLYCEROL 23RO (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL 97+% (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol (-)-2,3-O-Isopropylidene-sn-glycerol (-)-2,3-O-ISOPROPYLIDENE-SN-GLYCE (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol (R)-(-)-Sollketal [(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol ane-4-methanoL (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol, 98%, ee: 98% (R)-(-)-1,2-O-Isopropylideneglycerol 97% (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol> (R)-(-)-1,2-O-ISOPROPYLIDENEGLYCEROL (R)-(-)-SOLKETAL (R) - (-) - Glycerol Acetone (R)-(-)-2,2-Dimethyl-1 (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol 2,3-Isopropylidene-sn-glycerol L-α,β-Isopropylideneglycerol R-(-)-Glycerol Acetone Acetal (R)-2,2-Dimethyl-1,3-dioxolane-4-methanol / (R)-1,2-Isopropylideneglycerol R-(-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methnaol (R)-(-) -acetone Glycerol Formal Impurity 8 (R)-(?)-2,2-Dimethyl-1,3-dioxolane-4-methanol (R)-(-)-Acetoneglycerolketal (R)-(-)-1,2-Isopropylideneglycerol (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol, L-α,β-Isopropylideneglycerol (R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL

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(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Properties

SAFETY

Risk and Safety Statements

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol price More Price(69)

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Chemical Properties,Uses,Production

Uses

Chemical Properties

Uses

Uses

Synthesis

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol synthesis

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Suppliers

View Lastest Price from (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol manufacturers

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol Spectrum

14347-78-5((R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol)Related Search: