4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER
- CAS No.
- 330794-35-9
- Chemical Name:
- 4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER
- Synonyms
- tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate;4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID PINA;4-(N-BOC-AMINOMETHYL)PHENYLBORONIC ACID PICOL ESTER;4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER;4-((N-Boc-amino)methyl)phenylboronic acid pinacol ester;4-(TERT-BUTOXYCARBONYLAMINOMETHYL)PHENYLBORONIC ACID, PINACOL ESTER;[4-[[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]methyl]phenyl]boronic acid;4-[(tert-Butoxycarbonylamino)methyl]phenylboronic acid pinacol ester, 97%,;4-(tert-Butoxycarbonylaminomethyl)phenylboronic acid, pinacol ester;tert-Butyl N-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}carbamate 96%
- CBNumber:
- CB6188021
- Molecular Formula:
- C18H28BNO4
- Molecular Weight:
- 333.23
- MDL Number:
- MFCD06409942
- MOL File:
- 330794-35-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-((N-Boc-amino)methyl)phenylboronic acid pinacol ester AldrichCPR | CDS006042 | 100 mg | $77.9 |
| 4-(tert-Butoxycarbonylaminomethyl)phenylboronic acid, pinacol ester Aldrich | BML00061 | 1g | $197 |
| tert-Butyl N-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}carbamate 97% | OR310853 | 250mg | $21 |
| tert-Butyl N-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}carbamate 97% | OR310853 | 1g | $24 |
| tert-Butyl N-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}carbamate 97% | OR310853 | 5g | $58 |
| More product size | |||
| Boiling point | 452.0±38.0 °C(Predicted) |
|---|---|
| Density | 1.06±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | 12.16±0.46(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C18H28BNO4/c1-16(2,3)22-15(21)20-12-13-8-10-14(11-9-13)19-23-17(4,5)18(6,7)24-19/h8-11H,12H2,1-7H3,(H,20,21) |
| InChIKey | CUDCEJRRWNIPDL-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NCC1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1 |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P301+P312-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| HS Code | 2931900090 |
| Storage Class | 11 - Combustible Solids |
4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS006042 | 4-((N-Boc-amino)methyl)phenylboronic acid pinacol ester AldrichCPR | 330794-35-9 | 100 mg | $77.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | BML00061 | 4-(tert-Butoxycarbonylaminomethyl)phenylboronic acid, pinacol ester Aldrich | 330794-35-9 | 1g | $197 | 2026-04-30 | Buy |
| Apolloscientific | OR310853 | tert-Butyl N-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}carbamate 97% | 330794-35-9 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR310853 | tert-Butyl N-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}carbamate 97% | 330794-35-9 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR310853 | tert-Butyl N-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}carbamate 97% | 330794-35-9 | 5g | $58 | 2026-06-04 | Buy |
4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER Chemical Properties,Uses,Production
Synthesis
68819-84-1
73183-34-3
330794-35-9
1. Boc protection reaction: 4-bromobenzylamine (40.0 g, 217.0 mmol) was dissolved in THF (150 mL), di-tert-butyl dicarbonate (46.0 g, 217 mmol) was added, and the reaction was stirred at room temperature for 1 hour. After completion of the reaction, the mixture was concentrated in vacuum to give the crude product. The crude product was purified by silica gel column chromatography (eluent: 80:20 hexane/EtOAc) to afford the Boc-protected amine (63.0 g, 95% yield) as a white solid. 2. Borylation reaction: Boc-protected aryl bromide (30.0 g, 98.0 mmol) was dissolved in DMSO (100 mL), and bis(pinacolato)diboron (30.0 g, 118 mmol), KOAc (30.0 g, 306 mmol), and PdCl2(dppf) (0.2 mmol) were added sequentially. The reaction mixture was heated to 85 °C and stirred for 12 hours. After completion of the reaction, it was diluted with EtOAc (250 mL) and washed sequentially with water (2 x 150 mL) and brine (100 mL). The organic layer was dried with anhydrous Na2SO4 and concentrated in vacuum to obtain the crude product. Purification by silica gel column chromatography (eluent: 80:20 hexane/EtOAc) afforded the target compound (31.0 g, 97% yield) as a white solid.ESI-MS (M+H)+: 334.
References
[1] Patent: WO2015/89327, 2015, A1. Location in patent: Paragraph 0336
[2] Chemical Communications, 2013, vol. 49, # 30, p. 3110 - 3112
[3] Angewandte Chemie - International Edition, 2013, vol. 52, # 33, p. 8666 - 8670
[4] Angew. Chem., 2013, vol. 125, # 33, p. 8828 - 8832,5
[5] Patent: US2007/179115, 2007, A1. Location in patent: Page/Page column 19
4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. | 0431-80514535 13634302652 | Extension@chemextension.com | CHINA | 967 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Shanghai Daeyeon Chemicals Co., Ltd | 021-64478606 +8615900664856 | daeyeon001@vip.163.com | China | 2062 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
330794-35-9(4-((N-BOC-AMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER)Related Search:
1of2
