3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one
![3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Structure](CAS/GIF/893422-47-4.gif)
- CAS No.
- 893422-47-4
- Chemical Name:
- 3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one
- Synonyms
- Akti_2008;Akt1Akt2-IN-17;Akt1/Akt2-IN-1;Akt1/2 inhibitor 1;Akt1 and Akt2-IN-1;Akt-1 and Akt2-IN-1,Akt1 and Akt2IN1,Akt1 and Akt2 IN 1;3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one;3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)-1,6-naphthyridin-5(6H)-one;1,6-Naphthyridin-5(6H)-one, 3-phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-
- CBNumber:
- CB62473868
- Molecular Formula:
- C33H29N7O
- Molecular Weight:
- 539.63
- MDL Number:
- MFCD13184803
- MOL File:
- 893422-47-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Akt1 and Akt2-IN-1 | TKB42247 | 5mg | $900 |
| Akt1 and Akt2-IN-1 | TKB42247 | 2mg | $900 |
| Akt1 and Akt2-IN-1 | TKB42247 | 10mg | $1038.4 |
| Akt1 and Akt2-IN-1 | TKB42247 | 25mg | $1947 |
| Akt1 and Akt2-IN-1 | TKB42247 | 50mg | $2336.5 |
3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | TKB42247 | Akt1 and Akt2-IN-1 | 893422-47-4 | 5mg | $900 | 2026-06-05 | Buy |
| Biosynth | TKB42247 | Akt1 and Akt2-IN-1 | 893422-47-4 | 2mg | $900 | 2026-06-05 | Buy |
| Biosynth | TKB42247 | Akt1 and Akt2-IN-1 | 893422-47-4 | 10mg | $1038.4 | 2026-06-05 | Buy |
| Biosynth | TKB42247 | Akt1 and Akt2-IN-1 | 893422-47-4 | 25mg | $1947 | 2026-06-05 | Buy |
| Biosynth | TKB42247 | Akt1 and Akt2-IN-1 | 893422-47-4 | 50mg | $2336.5 | 2026-06-05 | Buy |
3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Chemical Properties,Uses,Production
Uses
Akt1/Akt2-IN-1 (Compound 17) is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM), with potent and balanced activity[1].
Biological Activity
Akt1 and Akt2-IN-1 are potent allosteric inhibitors, inhibiting Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM).
in vitro
Consistent with the allosteric mode of inhibition, Akt1 and Akt2-IN-1 (Compound 17) is dependent on the PH-domain for Akt inhibition, is selective for Akt1/2 over Akt3 (IC 50 =1900 nM), and is highly selective over other members of the AGC family of kinases (>50 μM vs PKA, PKC, SGK). It has moderate activity in an hERG binding assay (IC 50 =5610 nM) and is a substrate for human P-glycoprotein.
in vivo
Akt1 and Akt2-IN-1 (Compound 17) is well tolerated in at exposures that provide high levels of Akt1 and 2 inhibition in vivo. It has also been shown to inhibit the growth of A2780 tumors in vivo when used as monotherapy. Akt1 and Akt2-IN-1 (Compound 17) has potent inhibitory activity against Akt1 and 2 in vivo in a mouse lung and efficacy in a tumor xenograft model. And it shows good pharmacokinetics in rat with a low clearance of 4.6 mL/min/kg and a half-life of 3.8 h.
target
| Akt1 3.5 nM (IC 50 ) | Akt2 42 nM (IC 50 ) |
IC 50
Akt1: 3.5 nM (IC50); Akt2: 42 nM (IC50)
References
[1] Bilodeau MT, Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3178-82. DOI:10.1016/j.bmcl.2008.04.074
3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3504 | 58 |
View Lastest Price from 3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-22 | Akt1 and Akt2-IN-1
893422-47-4
|
10g | TargetMol Chemicals Inc. | ||||
 |
2025-07-22 | Akt1 and Akt2-IN-1
893422-47-4
|
$347.00-1490.00 | 10g | TargetMol Chemicals Inc. |
-
- Akt1 and Akt2-IN-1
893422-47-4
- $0.00
- TargetMol Chemicals Inc.
-
- Akt1 and Akt2-IN-1
893422-47-4
- $347.00-1490.00
- TargetMol Chemicals Inc.
