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ChemicalBook >> CAS DataBase List >>ledipasvir interMediate

ledipasvir interMediate

CAS No.
1441673-92-2
Chemical Name:
ledipasvir interMediate
Synonyms
Ledipasvir INT 1;edipasvir interMediate;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dim...;potassiuM (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester potassiuM salt;(6S)?-?5-?Azaspiro[2.4]?heptane-?5,?6-?dicarboxylicacid5-?(1,?1-?dimethylethyl)esterpotassiumsal;5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt, (6S)-;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt (1:1);5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt (1:1), (6S)-
CBNumber:
CB62710886
Molecular Formula:
C12H20KNO4
Molecular Weight:
281.39
MDL Number:
MFCD28385907
MOL File:
1441673-92-2.mol
MSDS File:
SDS
Last updated:2026-05-12 09:17:10
Product description Number Pack Size Price
(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt 97% AA001IY8 1g $16
(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt 97% AA001IY8 5g $56
Potassium (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate 95+% CD11256051 1g $226
potassium (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate 95% CM128196 5g $88
potassium (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate 95% CM128196 5g $88
More product size

ledipasvir interMediate Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

REACH Registrations Active

ledipasvir interMediate price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA001IY8 (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt 97% 1441673-92-2 1g $16 2026-05-28 Buy
aablocks AA001IY8 (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt 97% 1441673-92-2 5g $56 2026-05-28 Buy
Crysdot CD11256051 Potassium (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate 95+% 1441673-92-2 1g $226 2026-05-26 Buy
Chemenu CM128196 potassium (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate 95% 1441673-92-2 5g $88 2026-05-26 Buy
Chemenu CM128196 potassium (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate 95% 1441673-92-2 5g $88 2026-05-20 Buy
Product number Packaging Price Buy
AA001IY8 1g $16 Buy
AA001IY8 5g $56 Buy
CD11256051 1g $226 Buy
CM128196 5g $88 Buy
CM128196 5g $88 Buy

ledipasvir interMediate Chemical Properties,Uses,Production

Synthesis

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

1129634-44-1

ledipasvir interMediate

1441673-92-2

E. Potassium salt formation (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid (219 g) was dissolved in 2-methyltetrahydrofuran (880 mL) and the solution was subsequently heated to 35 °C. A THF solution of 1.0 M potassium tert-butanolate (1.05 L) was slowly added while maintaining an internal temperature not exceeding 40 °C. The reaction mixture was stirred for about 30 minutes, followed by slow cooling to 20°C over about 2 hours. After aging at 20 °C for 1 h, a filtration operation was performed. The filter cake was washed with 2-methyltetrahydrofuran (715 mL). The resulting solid was placed in a vacuum oven and dried at 40 °C for 24 h to give potassium (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate (212 g, 86% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ 4.07 (t, J = 7.3 Hz, 1H), 3.44 (d, J = 10.4 Hz, 1H), 3.35 (s, 1H), 3.10 (d, J = 10.4 Hz, 1H), 2.03 (dd, J = 12.3, 6.9 Hz, 1H), 1.89 (dd, J = 12.3, 8.0 Hz, 1H), 1.38 (s, 9H), 0.71-0.27 (m, 4H). 1H NMR (400 MHz, d6-DMSO) δ: 3.89 (dd, J = 8.6, 4.1 Hz, 0.4H, rotary isomer 1), 3.85 (dd, J = 8.6, 4.3 Hz, 0.6H, rotary isomer 2), 3.21-3.07 (m, 2H), 2.00-1.92 (m, 1H), 1.75-1.71 (m, 1H), 1.36 (s, 4H, rotary isomer 1), 1.32 (s, 5H, rotary isomer 2), 0.46-0.37 (m, 4H). 13C NMR (100 MHz, d6-DMSO) δ 174.5, 174.4, 154.1, 153.4, 77.2, 76.9, 62.3, 62.0, 54.1, 53.8, 38.7, 28.4, 28.3, 20.6, 19.9, 18.8, 11.6, 10.5, 10.2.

References

[1] Patent: US2013/324496, 2013, A1. Location in patent: Paragraph 0236-0237
[2] Patent: CN104478791, 2017, B. Location in patent: Paragraph 0069; 0070; 0071; 0072

1129634-44-1
1441673-92-2
Synthesis of ledipasvir interMediate from (S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

ledipasvir interMediate Preparation Products And Raw materials

Global( 105)Suppliers
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career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1319 58
Chengdu Aslee Biopharmaceuticals, Inc. 		28-85305008 CHINA 964 58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		21-38751876 +8615000076078 info@rochipharma.com China 505 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29093 58
AFINE CHEMICALS LIMITED 		+86-571-85134551 +86-18958018566 info@afinechem.com China 15079 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52704 58
Henan Alfa Chemical Co., Ltd 		+8618339805032 sale03@alfachem.cn China 9813 58

View Lastest Price from ledipasvir interMediate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ledipasvir interMediate pictures 2025-11-18 ledipasvir interMediate
1441673-92-2
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited
(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester potassiuM salt pictures 2020-02-26 (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester potassiuM salt
1441673-92-2
 5g 99%+ 100 tons Shaanxi Dideu Medichem Co. Ltd
ledipasvir interMediate pictures 2019-07-10 ledipasvir interMediate
1441673-92-2
 $1.00 1KG 98% 150KG Career Henan Chemical Co
potassiuM (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-diMethylethyl) ester potassiuM salt (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester potassium salt (1:1) edipasvir interMediate Ledipasvir INT 1 5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt (1:1), (6S)- 5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester, potassium salt, (6S)- (6S)?-?5-?Azaspiro[2.4]?heptane-?5,?6-?dicarboxylicacid5-?(1,?1-?dimethylethyl)esterpotassiumsal (6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dim... 1441673-92-2 256387-87-7 C12H18NO4K C12H18KNO4
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