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ChemicalBook >> CAS DataBase List >>Spermine

Spermine

CAS No.
71-44-3
Chemical Name:
Spermine
Synonyms
SPERMINE TETRAHYDROCHLORIDE;Spermin;N1,N1'-(butane-1,4-diyl)bis(propane-1,3-diaMine);NEURIDINE HYDROCHLORIDE;MUSCULAMINE HYDROCHLORIDE;DJtPAT;Spermine;NSC 268508;Spermine,97%;Spermine >98%
CBNumber:
CB6275334
Molecular Formula:
C10H26N4
Molecular Weight:
202.34
MDL Number:
MFCD00012914
MOL File:
71-44-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-29 19:27:05
Product description Number Pack Size Price
Spermine ≥99.0% (GC) 85590 5g $365
Spermine analytical standard 55513 100mg $81.5
Spermine P3251 1G $58
Spermine P3251 5G $173
Spermine ≥95% 18041 1g $41
More product size

Spermine Properties

Melting point 28-30 (lit.)
Boiling point 150 °C/5 mmHg (lit.)
Density 0.937
refractive index 1.4850 (estimate)
Flash point >230 °F
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form powder
pka 10.88±0.19(Predicted)
color Colorless to off-white
biological source microbial
synthetic
Water Solubility Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
Sensitive Air Sensitive & Hygroscopic
Merck 14,8743
BRN 1751791
Stability Hygroscopic
Cosmetics Ingredients Functions SKIN CONDITIONING
InChI 1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChIKey PFNFFQXMRSDOHW-UHFFFAOYSA-N
SMILES [H]N(CCCN)CCCCN([H])CCCN
LogP -0.543 (est)
CAS DataBase Reference 71-44-3(CAS DataBase Reference)
FDA UNII 2FZ7Y3VOQX
NIST Chemistry Reference Spermine(71-44-3)
EPA Substance Registry System 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3)
UNSPSC Code 85151701
NACRES NA.75

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318-H314
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338-P310
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  Xi,C
Risk Statements  36/38-34
Safety Statements  26-36-45-36/37/39-27
RIDADR  UN 3259 8/PG 2
WGK Germany  3
RTECS  EJ7230000
F  3-10
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
HS Code  29212900
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Eye Dam. 1
Skin Corr. 1B
NFPA 704
1
3 1

Spermine price More Price(107)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 85590 Spermine ≥99.0% (GC) 71-44-3 5g $365 2026-04-30 Buy
Sigma-Aldrich 55513 Spermine analytical standard 71-44-3 100mg $81.5 2026-04-30 Buy
TCI Chemical P3251 Spermine 71-44-3 1G $58 2026-04-30 Buy
TCI Chemical P3251 Spermine 71-44-3 5G $173 2026-04-30 Buy
Cayman Chemical 18041 Spermine ≥95% 71-44-3 1g $41 2026-04-30 Buy
Product number Packaging Price Buy
85590 5g $365 Buy
55513 100mg $81.5 Buy
P3251 1G $58 Buy
P3251 5G $173 Buy
18041 1g $41 Buy

Spermine Chemical Properties,Uses,Production

Description

Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.

Chemical Properties

White to slightly off-white powder crysta

Uses

immune modulator

Uses

Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes

Uses

Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).

Definition

ChEBI: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.

General Description

Spermineis a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.

Biochem/physiol Actions

Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

storage

+4°C (desiccate)

References

[1] fakler b, brndle u, glowatzki e, et al. strong voltage-dependent inward rectification of inward rectifier k+ channels is caused by intracellular spermine[j]. cell, 1995, 80(1): 149-154.
[2] til h p, falke h e, prinsen m k, et al. acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[j]. food and chemical toxicology, 1997, 35(3): 337-348.

Spermine Preparation Products And Raw materials

Global( 405)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Paron Technology Co., Ltd 		+86-13770590702 +86-13770590702 arthur@parontek.com China 235 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5983 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20122 58
Hangzhou Hyper Chemicals Limited 		+86-0086-57187702781 +8613675893055 info@hyper-chem.com China 310 58
Shaanxi Xianhe Biotech Co., Ltd 		+86-17709210191; +8617709210191 Jerry@xhobio.com China 906 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 FandaChem@Gmail.com China 1399 55
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58

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View Lastest Price from Spermine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Spermine pictures 2026-06-05 Spermine
71-44-3
 1kg 98.2% 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Spermine pictures 2026-06-02 Spermine
71-44-3
 1KG 0.99 1000KG Shaanxi Xianhe Biotech Co., Ltd
Spermine pictures 2026-05-29 Spermine
71-44-3
 $40.00 99.97% 10g TargetMol Chemicals Inc.
  • Spermine pictures
  • Spermine
    71-44-3
  • 98.2%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Spermine pictures
  • Spermine
    71-44-3
  • $0.00
  • 0.99
  • Shaanxi Xianhe Biotech Co., Ltd
  • Spermine pictures
  • Spermine
    71-44-3
  • $40.00
  • 99.97%
  • TargetMol Chemicals Inc.
SPERMINE HYDROCHLORIDE n,n’-bis(3-aminopropyl)-4-butanediamine n,n’-bis(3-aminopropyl)-4-diaminobutane N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CL N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE N,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDE N,N'-BIS(3-AMINOPROPYL)-BUTANE-1,4-DIAMINE TETRAHYDROCHLORIDE NEURIDINE TETRAHYDROCHLORIDE MUSCULAMINE TETRAHYDROCHLORIDE Spermine SOYASAPONIN IV(SH) Spermine,N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine Spermine >98% N,N'-Bis(3-aminopropyl)-1,4-butanediamine GERONTINE TETRAHYDROCHLORIDE DIAMINOPROPYLTETRAMETHYLENEDIAMINE HYDROCHLORIDE 1,4-BIS(AMINOPROPYL)BUTANEDIAMINE TETRAHYDROCHLORIDE 4,9-diazadodecamethylenediamine N,N-Bis(3-aminopropyl)-1,4-diaminobutane~Gerontine~Musculamine~Neuridine Spermine N,N-Bis(3-aminopropyl)-1,4-diaminobutane SPERMINE FREE BASE CELL CULTURE TESTED Spermine,97% Sperminedihydrate,97% BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE NSC 268508 SPERMINE FREE BASE extrapure 1,4-Bis(aminopropyl)butanediamine 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- 1,4-Diaminobutane, N,N'-bis(3-aminopropyl)- 4,9-Diaza-1,12-dodecanediamine 4,9-Diazadodecane-1,12-diamine N,NBis(2-aminopropyl)-1,4-butane-diamine, N,NBis(2-aminopropyl)tetramethylenediamine SPERMINE >= 99.0% (GC) bis(propane-1,3-diamine) N1,N1'-(Butane-1,4-diyl) 1,4-Butanediamine, N1,N4-bis(3-aminopropyl)- DJtPAT Spermine CAS 71-44-3 with Best Price Fast Delivery Good Quality Spermine (NSC-268508 (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl}) amine Spermine, ≥99% (GC) Spermin NEURIDINE HYDROCHLORIDE MUSCULAMINE HYDROCHLORIDE N,N'-bis(3-aminopropyl)butane-1,4-diamine Gerontine|||Musculamine|||4,9-Diaza-1,12-dodecanediamine|||NSC 268508|||Neuridine Spermine in methanol Spermine (Standard) N,N'-bis(3-aminopropyl)-1,4-butyldiamine Gadobutrol Impurity 180 Monomer SPERMINE TETRAHYDROCHLORIDE N1,N1'-(butane-1,4-diyl)bis(propane-1,3-diaMine) 71-44-3 77-44-3 H2NCH23NHCH23NH2 NH2CH23NHCH24NHCH23NH2 H2NCNHNHCH24NH2 C10H26N4
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