4-Oxo-4H-1-benzopyran-2-carboxylic acid
- CAS No.
- 4940-39-0
- Chemical Name:
- 4-Oxo-4H-1-benzopyran-2-carboxylic acid
- Synonyms
- CHROMOCARB;Chromone-2-carboxilic acid;4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID;lp-1;atremon;chromocarbe;LP-1 Cells Line;TIMTEC-BB SBB003660;LABOTEST-BB LT00454887;chromonecarboxylicacid
- CBNumber:
- CB6322423
- Molecular Formula:
- C10H6O4
- Molecular Weight:
- 190.15
- MDL Number:
- MFCD00006838
- MOL File:
- 4940-39-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Oxo-4H-1-benzopyran-2-carboxylic acid 97% | 189782 | 5g | $52.6 |
| Chromone-2-carboxylic Acid >98.0%(HPLC)(T) | O0290 | 5g | $172 |
| Chromone-2-carboxylic Acid >98.0%(HPLC)(T) | O0290 | 25g | $611 |
| Chromone-2-carboxylic acid Asreported | 269034 | 10g | $368 |
| Chromone-2-carboxylic acid Asreported | 269034 | 25g | $559 |
| More product size | |||
| Melting point | 260 °C (dec.)(lit.) |
|---|---|
| Boiling point | 285.64°C (rough estimate) |
| Density | 1.3366 (rough estimate) |
| refractive index | 1.5280 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | alcohol: soluble |
| pka | 2.28±0.20(Predicted) |
| form | Powder |
| color | White to beige |
| Water Solubility | sparingly soluble |
| Merck | 14,2237 |
| BRN | 146442 |
| InChI | InChI=1S/C10H6O4/c11-7-5-9(10(12)13)14-8-4-2-1-3-6(7)8/h1-5H,(H,12,13) |
| InChIKey | RVMGXWBCQGAWBR-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)OC2=CC=CC=C2C(=O)C=1 |
| CAS DataBase Reference | 4940-39-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | FY38S0790W |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DJ2476000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | LD50 intraperitoneal in mouse: 585mg/kg | |||||||||
| NFPA 704 |
|
4-Oxo-4H-1-benzopyran-2-carboxylic acid price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 189782 | 4-Oxo-4H-1-benzopyran-2-carboxylic acid 97% | 4940-39-0 | 5g | $52.6 | 2026-04-30 | Buy |
| TCI Chemical | O0290 | Chromone-2-carboxylic Acid >98.0%(HPLC)(T) | 4940-39-0 | 5g | $172 | 2026-04-30 | Buy |
| TCI Chemical | O0290 | Chromone-2-carboxylic Acid >98.0%(HPLC)(T) | 4940-39-0 | 25g | $611 | 2026-04-30 | Buy |
| Usbiological | 269034 | Chromone-2-carboxylic acid Asreported | 4940-39-0 | 10g | $368 | 2026-06-03 | Buy |
| Usbiological | 269034 | Chromone-2-carboxylic acid Asreported | 4940-39-0 | 25g | $559 | 2026-06-03 | Buy |
4-Oxo-4H-1-benzopyran-2-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
vascular protectant
Uses
4-oxo-4H-1-Benzopyran-2-carboxylic Acid acts as an inhibitor of monoamine oxidase A & B. Also functions as a novel type of tyrosine phosphatase 1B inhibitor in studies, due to a structure derived from formylchromone.
Uses
Chromone-2-carboxylic acid is used in the cyclic form 3-oxopyrazolidino[4,52, 3]-chroman-4-one, gives the azide of chromone-2-carboxylic acid, the curtius rearrangement of which is used to synthesize a number of 2-acylaminochromones and it is an orally active antiallergic agent.
Definition
ChEBI: 4-oxo-1-benzopyran-2-carboxylic acid is a member of chromones.
General Description
Nasal absorption of 4-oxo-4H-1-benzopyran-2-carboxylic acid has been investigated in the male Wistar rat.
Synthesis
118-93-4
95-92-1
4940-39-0
Example 8 Synthesis of 4-oxo-4H-chromene-2-carboxylic acid Procedure: a mixture of diethyl oxalate (110 mL, 810 mmol) and 2'-hydroxyacetophenone (44 mL, 365 mmol) was added slowly and dropwise to a solution of sodium ethanolate (76 g, 1.11 mol) in ethanol (600 mL) over a period of 20 minutes. The reaction mixture was heated to 80 °C and maintained for 1 h, followed by cooling to room temperature. Water (500 mL) and ether (600 mL) were added to the reaction system and the pH was adjusted with concentrated hydrochloric acid to 2. The organic phase was separated and the aqueous phase was further extracted with ether (2 x 600 mL). The organic phases were combined, washed with saturated aqueous sodium chloride solution (2 x 600 mL), dried over anhydrous magnesium sulfate and concentrated to give a brown oily solid. The solid was mixed with glacial acetic acid (440 mL) and concentrated hydrochloric acid (110 mL) and heated to 85 °C for overnight reaction. After the reaction was completed, it was cooled to room temperature, diluted with water (550 mL) and the solid was collected by filtration. The solid was washed with water (2 x 125 mL) and dried in a vacuum oven to give a purple solid product (58 g, 83% yield). Melting point: 260-261 °C. 1H NMR (300 MHz, DMSO-d6) δ 8.03 (m, 1H), 7.85 (m, 1H), 7.71 (m, 1H), 7.51 (m, 1H), 6.89 (s, 1H).
References
[1] Patent: US6469031, 2002, B1
[2] Patent: US6051586, 2000, A
[3] Zhurnal Obshchei Khimii, 1959, vol. 29, p. 1026,1029; engl. Ausg. S. 1004, 1006
[4] Helvetica Chimica Acta, 1951, vol. 34, p. 767,774
[5] Chimica Therapeutica, 1968, vol. 3, p. 270 - 273
4-Oxo-4H-1-benzopyran-2-carboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8828 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
View Lastest Price from 4-Oxo-4H-1-benzopyran-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-11 | Chromocarb
4940-39-0
|
$29.00 | 99.91% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-11 | Chromocarb
4940-39-0
|
$29.00 | 99.91% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-11-18 | 4-Oxo-4H-1-benzopyran-2-carboxylic acid
4940-39-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- Chromocarb
4940-39-0
- $29.00
- 99.91%
- TargetMol Chemicals Inc.
-
- Chromocarb
4940-39-0
- $29.00
- 99.91%
- TargetMol Chemicals Inc.
-
- 4-Oxo-4H-1-benzopyran-2-carboxylic acid
4940-39-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
