(S)-3-Hydroxy-gamma-butyrolactone
- CAS No.
- 7331-52-4
- Chemical Name:
- (S)-3-Hydroxy-gamma-butyrolactone
- Synonyms
- (S)-4-Hydroxydihydrofuran-2(3H)-one;(s)-(-)-á-hydroxy-;-4-Hydroxydihydrofuran-2(3H);(S)-3-Hydroxy-γ-butyrolactone;(S)-(-)-3-HYDROXYBUTYROLACTONE;(S)-(-)-3-HYDROXY-GAMMA-BUTYROLACTONE;2(3H)-FURANONE, DIHYDRO-3-HYDROXY-, (S);2(3H)-FURANONE, DIHYDRO-4-HYDROXY-, (S);(S)-3-Hydroxy-gamma-;Levetiracetam Impurity 65
- CBNumber:
- CB6360496
- Molecular Formula:
- C4H6O3
- Molecular Weight:
- 102.09
- MDL Number:
- MFCD00211247
- MOL File:
- 7331-52-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (S)-β-Hydroxy-γ-butyrolactone 96% | 422797 | 1g | $75.4 |
| (S)-3-Hydroxy-gamma-butyrolactone >95.0%(GC) | H0939 | 1g | $53 |
| (S)-3-Hydroxy-gamma-butyrolactone >95.0%(GC) | H0939 | 5g | $149 |
| (S)-3-Hydroxy-gamma-butyrolactone | FH60203 | 5g | $192.2 |
| (S)-3-Hydroxy-gamma-butyrolactone | FH60203 | 10g | $346 |
| More product size | |||
| Boiling point | 98-100 °C0.3 mm Hg(lit.) |
|---|---|
| Density | 1.241 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,2-8°C |
| pka | 12.87±0.20(Predicted) |
| Appearance | Brown to reddish brown Liquid |
| optical activity | [α]21/D 81°, c = 2 in ethanol |
| Water Solubility | Miscible with water, alcohol and other organic solvent. Immiscible with light petroleum. |
| BRN | 1280864 |
| InChI | InChI=1S/C4H6O3/c5-3-1-4(6)7-2-3/h3,5H,1-2H2/t3-/m0/s1 |
| InChIKey | FUDDLSHBRSNCBV-VKHMYHEASA-N |
| SMILES | O1C[C@@H](O)CC1=O |
| CAS DataBase Reference | 7331-52-4(CAS DataBase Reference) |
| FDA UNII | 2LIE7314JH |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 29322090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
(S)-3-Hydroxy-gamma-butyrolactone price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 422797 | (S)-β-Hydroxy-γ-butyrolactone 96% | 7331-52-4 | 1g | $75.4 | 2026-04-30 | Buy |
| TCI Chemical | H0939 | (S)-3-Hydroxy-gamma-butyrolactone >95.0%(GC) | 7331-52-4 | 1g | $53 | 2021-12-16 | Buy |
| TCI Chemical | H0939 | (S)-3-Hydroxy-gamma-butyrolactone >95.0%(GC) | 7331-52-4 | 5g | $149 | 2021-12-16 | Buy |
| Biosynth | FH60203 | (S)-3-Hydroxy-gamma-butyrolactone | 7331-52-4 | 5g | $192.2 | 2026-06-04 | Buy |
| Biosynth | FH60203 | (S)-3-Hydroxy-gamma-butyrolactone | 7331-52-4 | 10g | $346 | 2026-06-04 | Buy |
(S)-3-Hydroxy-gamma-butyrolactone Chemical Properties,Uses,Production
Description
(S)-3-Hydroxy-gamma-butyrolactone is an important intermediate in organic synthesis and an important chiral pool. It is mainly used in the synthesis of some natural products and some bioactive chiral drugs or antibiotic chiral drugs. For example, it is a key intermediate in synthesis of nerve regulator (R)-GABOB and brain metabolic accelerant S-oxiracetam (S-ORC). It can be deoxidized to (S)-(+)-3-Hydroxytetrahydrofuran which is an important intermediate of anti-AIDS drugs. It is also used in the synthesis of S(-)-3-hydroxy-4-bromobutyric acid which is a potential stabilizer.
Chemical Properties
Colorless to light yellow liquid.
Uses
(S)-3-Hydroxy-γ-butyrolactone can be used as an anticancer drug resistance inhibitor.
Application
(S)-3-Hydroxy-gamma-butyrolactone is an important synthetic intermediate for a variety of chiral compounds. It is a key intermediate for preparing neuromediator (R)-GABOB, l-carnitine, and HMG-CoA reductase inhibitor, CI-981. (S)-3-Hydroxy-gamma-butyrolactone has been reported as a satiety and potentiating agent to neuroleptic drugs. It is widely used in the pharmaceutical industry as a chiral building block for the statin class of cholesterol-reducing drugs such as Crestor and Lipitor, as well as the antibiotic Zyvox and the antihyperlipidemic medication Zetia. Other pharmaceuticals derived from 3HBL include HIV inhibitors and the nutritional supplement L-carnitine. 3HBL can readily be transformed into a variety of three-carbon building blocks and has been listed as one of the top value-added chemicals from biomass by the US Department of Energy[1-2].
Synthesis
Optically pure (S)-3-hydroxy-gamma-butyrolactone, a crucial chiral building block in the pharmaceutical industry, was synthesized from L: -malic acid by combining selective hydrogenation and lipase-catalyzed hydrolysis. Lipase from Candida rugosa was found to be the most efficient enzyme for the hydrolysis of (S)-beta-benzoyloxy-gamma-butyrolactone[1].
Precautions
For best results, Store in cool, dry place in tightly closed containers, under inert gas and protected from moisture as this substance is moisture sensitive. (S)-3-Hydroxy-gamma-butyrolactone is incompatible with oxidizing agents. This chemical causes skin irritation and serious eye irritation.
References
[1] Pradeep Kumar. “A simple and practical approach to enantiomerically pure (S)-3-hydroxy-γ-butyrolactone: synthesis of (R)-4-cyano-3-hydroxybutyric acid ethyl ester.” Tetrahedron, asymmetry 16 16 (2005): Pages 2717-2721.
[2] Sang-Hyun Lee, Hong-Sun Uh, Oh-Jin Park. “A chemoenzymatic approach to the synthesis of enantiomerically pure (S)-3-hydroxy-γ-butyrolactone.” Applied Microbiology and Biotechnology 79 3 (2008): 355–362.
(S)-3-Hydroxy-gamma-butyrolactone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | +8617731987558 | xingjiu@xingjiubiotech.com | China | 989 | 58 |
| Hebei Nafu Technology Co. , Ltd. | +8615075022224 | 17745771666@hebeinafu.com | China | 308 | 58 |
| Hebei Gongyuan New Material Technology Co., Ltd. | +8617331136198 | Grace@hebeisyjl.com | China | 479 | 58 |
| Wuhan wingroup Pharmaceutical Co., Ltd | +86-13296627870; +8613296627870 | info@whwingroup.com | China | 695 | 58 |
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3373 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Suzhou Sanyi Polymer Chemical Technology Co., Ltd. | +8615571922873 | 15571922873@163.com | China | 102 | 58 |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 283 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 | da@zhongda-biotech.com | China | 232 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
Related articles
- (S)-3-Hydroxy-gamma-butyrolactone: Chiral Building Block
- (S)-3-Hydroxy-gamma-butyrolactone is biosynthesized from glucose/xylose by engineered E. coli and yeast with pathway optimizat....
- Jan 21，2026
View Lastest Price from (S)-3-Hydroxy-gamma-butyrolactone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-25 | (S)-3-Hydroxy-γ-butyrolactone
7331-52-4
|
$1.00 | 1kg | 99% | 10 tons | RongNa Biotechnology Co.,Ltd | |
 |
2026-07-21 | (S)-3-Hydroxy-gamma-butyrolactone
7331-52-4
|
2Kg/Bag | 99% up, High Density | 20 tons | Sinoway Industrial co., ltd. | ||
 |
2026-07-08 | (S)-3-Hydroxy-gamma-butyrolactone
7331-52-4
|
1kg | 99% | 99999 | Rongchuang International |
-
- (S)-3-Hydroxy-γ-butyrolactone
7331-52-4
- $1.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- (S)-3-Hydroxy-gamma-butyrolactone
7331-52-4
- $0.00
- 99% up, High Density
- Sinoway Industrial co., ltd.
-
- (S)-3-Hydroxy-gamma-butyrolactone
7331-52-4
- $0.00
- 99%
- Rongchuang International
7331-52-4((S)-3-Hydroxy-gamma-butyrolactone)Related Search:
1of4
