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ChemicalBook >> CAS DataBase List >>Cefotiam hydrochloride

Cefotiam hydrochloride

CAS No.
66309-69-1
Chemical Name:
Cefotiam hydrochloride
Synonyms
CEFOTIAM 2HCL;Spizef;Ceftiam;Halospor;Sporidyn;Pansporin;Cefapicol;Pansporine;Kemisporin;Sepidnarin
CBNumber:
CB6386641
Molecular Formula:
C18H23N9O4S3.HCl
Molecular Weight:
562.08
MDL Number:
MFCD01682052
MOL File:
66309-69-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:42:37
Product description Number Pack Size Price
Cefotiam dihydrochloride hydrate ≥98% (HPLC) SML0056 10mg $94.8
Cefotiam dihydrochloride FC19863 1g $398.75
Cefotiam dihydrochloride FC19863 2g $606.1
Cefotiam dihydrochloride FC19863 5g $1116.5
Cefotiam dihydrochloride FC19863 10g $1435.5
More product size

Cefotiam hydrochloride Properties

Melting point >93°C (dec.)
Boiling point 94℃
RTECS XI0367000
Flash point >110°(230°F)
storage temp. Inert atmosphere,2-8°C
solubility H2O: ≥22M
form powder
color white to tan
Water Solubility Soluble in water
Stability Hygroscopic
InChIKey BWRRTAXZCKVRON-DGPOFWGLSA-N
CAS DataBase Reference 66309-69-1(CAS DataBase Reference)
FDA UNII H7V12WDZ93

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3
HS Code  2941906000

Cefotiam hydrochloride price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0056 Cefotiam dihydrochloride hydrate ≥98% (HPLC) 66309-69-1 10mg $94.8 2026-04-30 Buy
Biosynth FC19863 Cefotiam dihydrochloride 66309-69-1 1g $398.75 2026-06-04 Buy
Biosynth FC19863 Cefotiam dihydrochloride 66309-69-1 2g $606.1 2026-06-04 Buy
Biosynth FC19863 Cefotiam dihydrochloride 66309-69-1 5g $1116.5 2026-06-04 Buy
Biosynth FC19863 Cefotiam dihydrochloride 66309-69-1 10g $1435.5 2026-06-04 Buy
Product number Packaging Price Buy
SML0056 10mg $94.8 Buy
FC19863 1g $398.75 Buy
FC19863 2g $606.1 Buy
FC19863 5g $1116.5 Buy
FC19863 10g $1435.5 Buy

Cefotiam hydrochloride Chemical Properties,Uses,Production

Description

Cefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.

Uses

Cefotiam hydrochloride (SCE-963 hydrochloride) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Definition

ChEBI: Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.

brand name

Ceradon (Takeda).

Pharmacokinetics

Cefotiam Hydrochloride is the hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Cefotiam hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 311)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16512 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21586 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		17791478691 yklbiotech@163.com CHINA 296 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hebei Runbin Biotechnology Co. LTD 		13180553332 2179877681@qq.com CHINA 990 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58

View Lastest Price from Cefotiam hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cefotiam hydrochloride pictures 2026-06-18 Cefotiam hydrochloride
66309-69-1
 1KG 81%min 500kg WUHAN FORTUNA CHEMICAL CO., LTD
Cefotiam hydrochloride pictures 2026-05-11 Cefotiam hydrochloride
66309-69-1
 $52.00-166.00 99.78% 10g TargetMol Chemicals Inc.
Cefotiam hydrochloride pictures 2026-04-17 Cefotiam hydrochloride
66309-69-1
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Cefotiam hydrochloride Spectrum

cefotiam hydrochloride 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)- Abbott 48999 Halospor Pansporin Pansporine Spizef Sporidyn Cefotiam Hydrochloride (350 mg) (6R,7R)-7-[2-(2-aMino-1,3-thiazol-4-yl)acetaMido]-3-[({1-[2-(diMethylaMino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6r-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride Cefapicol Kemisporin Sepidnarin (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (6R,7R)-7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[[1-(2-dimethylaminoethyl)tetrazol-5-yl]thio]methyl]-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride (6R,7R)-7-[2-(2-azanyl-1,3-thiazol-4-yl)ethanoylamino]-3-[[1-(2-dimethylaminoethyl)-1,2,3,4-tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride Cefotiam Hydrochloride (325 mg) cefotiamdihydrochloride dihydrochloride,(6r-trans)--oxo (6R,7R)-7-[[2-(2-AMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrochloride 20MG/100MG/KG 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-(2-aMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-,hydrochloride (1:2), (6R,7R)- (6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate Cefotiam dihydrochloride hydrate Ceftiam cefotian Hydrochloride Cefotiam DiHCl 7-[[2-(2-amino-4-thiazolyl)-1-oxoethyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-5-tetrazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride Cefotiam Dihydrochloride(Crude) SCE-963 hydrochloride (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride Cefotiam hydrochloride USP/EP/BP (6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid Cefotiam hydrochloride Impurities Cefotiam Hydrochloride (1098005) Cefotiame hydrochloride Cefoperam hydrochloride (6R,7R)-7-[2-(2-Amino-4-thiazolyl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Dihydrochloride Cefotiam Hydrochloride RS Cefotiam hydrochloride (Standard) CEFOTIAM 2HCL 66309-69-1 6309-69-1 66309-69-01 C18H23N9O4S3 C18H23N9O4S3HCl C18H23N9O4S32HCl C18H24ClN9O4S3 C18H25Cl2N9O4S3 59855 ANTRYPOL Intermediates & Fine Chemicals Pharmaceuticals
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