Lycorine hydrochloride
- CAS No.
- 2188-68-3
- Chemical Name:
- Lycorine hydrochloride
- Synonyms
- LYCORINE;LYCORIN;NARCISSIN(P);(-)-LYCORINE;Lycorine chloride;Hydrochloric Lycorine;Licorin hydrochloride;Lycorine hydrochloride;Licorine hydrochloride;Amarylline hydrochloride
- CBNumber:
- CB6415905
- Molecular Formula:
- C16H17NO4
- Molecular Weight:
- 287.31
- MDL Number:
- MFCD00243111
- MOL File:
- 2188-68-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Lycorine hydrochloride ≥98% (TLC), powder | L5139 | 20mg | $397 |
| Lycorine hydrochloride (Lycorine chloride) ≥98% | 300599 | 20mg | $263 |
| Lycorine Hydrochloride | TRC-L487550-50MG | 50mg | $209 |
| Lycorine Hydrochloride | TRC-L487550-500MG | 500mg | $1547 |
| Lycorine Hydrochloride | TRC-L487550-20MG | 20mg | $154 |
| More product size | |||
| Melting point | 206 °C |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in water (15 mg/ml) |
| form | powder |
| color | White to off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month. |
| InChI | 1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1 |
| InChIKey | VUVNTYCHKZBOMV-NVJKKXITSA-N |
| SMILES | Cl.O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@H]([C@@H]1O)[C@@H]23 |
| FDA UNII | 58F70VH0HS |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
Lycorine hydrochloride price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L5139 | Lycorine hydrochloride ≥98% (TLC), powder | 2188-68-3 | 20mg | $397 | 2026-04-30 | Buy |
| Usbiological | 300599 | Lycorine hydrochloride (Lycorine chloride) ≥98% | 2188-68-3 | 20mg | $263 | 2026-06-03 | Buy |
| TRC | TRC-L487550-50MG | Lycorine Hydrochloride | 2188-68-3 | 50mg | $209 | 2026-06-03 | Buy |
| TRC | TRC-L487550-500MG | Lycorine Hydrochloride | 2188-68-3 | 500mg | $1547 | 2026-06-03 | Buy |
| TRC | TRC-L487550-20MG | Lycorine Hydrochloride | 2188-68-3 | 20mg | $154 | 2026-06-03 | Buy |
Lycorine hydrochloride Chemical Properties,Uses,Production
Description
Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Lycoris radiata bulbs.
Uses
Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
Biochem/physiol Actions
A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.
in vivo
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry[1].
| Animal Model: | 6- to 8-week-old BALB/C nude mice[1] |
| Dosage: | 0 μg, 7.5 μg, 15 μg |
| Administration: | Subcutaneous injection; for 14 days |
| Result: | Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry. |
References
[1] GIEDRIUS MILIAUSKAS. Identification of Radical Scavenging Compounds in Rhaponticum carthamoides by Means of LC-DAD-SPE-NMR[J]. Journal of Natural Products , 2005, 68 2: 168-172. DOI:10.1021/np0496901
[2] JIANGNING LIU. Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication.[J]. Virology Journal, 2011: 483. DOI:10.1186/1743-422x-8-483
[3] YOSHIAKI ONISHI Y Y Yasuhiro Kawano. Lycorine, a candidate for the control of period length in mammalian cells.[J]. Cellular Physiology and Biochemistry, 2012, 29 3-4: 407-416. DOI:10.1159/000338495
[4] ZHIFEI CAO . Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity[J]. Toxicology letters, 2013, 218 2: Pages 174-185. DOI:10.1016/j.toxlet.2013.01.018
[5] LIANGDE ZHENG. The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy.[J]. Autophagy, 2019. DOI:10.1080/15548627.2019.1668228
Lycorine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 477 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 4616 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 1169 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from Lycorine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | Lycorine hydrochloride
2188-68-3
|
1KG | 98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
 |
2026-06-02 | Lycorine hydrochloride
2188-68-3
|
$39.00-97.00 | 99.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-22 | Lycorine hydrochloride
2188-68-3
|
1kg | 99% | 1000 kg | BINBO BIOLOGICAL CO.,LTD |
-
- Lycorine hydrochloride
2188-68-3
- $0.00
- 98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Lycorine hydrochloride
2188-68-3
- $39.00-97.00
- 99.88%
- TargetMol Chemicals Inc.
-
- Lycorine hydrochloride
2188-68-3
- $0.00
- 99%
- BINBO BIOLOGICAL CO.,LTD
