6-Chloro-2-methyl-3-nitropyridine
- CAS No.
- 22280-60-0
- Chemical Name:
- 6-Chloro-2-methyl-3-nitropyridine
- Synonyms
- 2-CHLORO-6-METHYL-3-NITROPYRIDINE;2-CHLORO-5-NITRO-6-METHYLPYRIDINE;TIMTEC-BB SBB003830;TIMTEC-BB SBB003832;2-CHLORO-5-NITRO-6-PICOLINE;6-CHLORO-3-NITRO-2-PICOLINE;6-Chloro-2-Methyl-3-nitro...;2-CHLORO-6-METHYL-5-NITROPYRI;6-Chloro-2-methyl-3-nitropyrid;6-Chloro-3-nitro-2-picoline,98%
- CBNumber:
- CB6466200
- Molecular Formula:
- C6H5ClN2O2
- Molecular Weight:
- 172.57
- MDL Number:
- MFCD00234160
- MOL File:
- 22280-60-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 6-Chloro-2-methyl-3-nitropyridine >98.0%(GC) | C2434 | 1g | $30 |
| 6-Chloro-2-methyl-3-nitropyridine >98.0%(GC) | C2434 | 5g | $62 |
| 6-Chloro-2-methyl-3-nitropyridine Asreported | 270286 | 10g | $232 |
| 6-Chloro-2-methyl-3-nitropyridine Asreported | 270286 | 25g | $343 |
| 2-CHLORO-5-NITRO-6-METHYLPYRIDINE 97% | 57634 | 25G | $45 |
| More product size | |||
| Melting point | 54-58 °C |
|---|---|
| Boiling point | 200°C (rough estimate) |
| Density | 1.5610 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Powder |
| pka | -3.26±0.10(Predicted) |
| color | Light beige to brown |
| InChI | InChI=1S/C6H5ClN2O2/c1-4-5(9(10)11)2-3-6(7)8-4/h2-3H,1H3 |
| InChIKey | GHSRMSJVYMITDX-UHFFFAOYSA-N |
| SMILES | C1(C)=NC(Cl)=CC=C1[N+]([O-])=O |
| CAS DataBase Reference | 22280-60-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H301-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-20/21/22-22 | |||||||||
| Safety Statements | 36/37/39-26 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
6-Chloro-2-methyl-3-nitropyridine price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2434 | 6-Chloro-2-methyl-3-nitropyridine >98.0%(GC) | 22280-60-0 | 1g | $30 | 2026-04-30 | Buy |
| TCI Chemical | C2434 | 6-Chloro-2-methyl-3-nitropyridine >98.0%(GC) | 22280-60-0 | 5g | $62 | 2026-04-30 | Buy |
| Usbiological | 270286 | 6-Chloro-2-methyl-3-nitropyridine Asreported | 22280-60-0 | 10g | $232 | 2026-06-03 | Buy |
| Usbiological | 270286 | 6-Chloro-2-methyl-3-nitropyridine Asreported | 22280-60-0 | 25g | $343 | 2026-06-03 | Buy |
| AstaTech | 57634 | 2-CHLORO-5-NITRO-6-METHYLPYRIDINE 97% | 22280-60-0 | 25G | $45 | 2026-04-30 | Buy |
6-Chloro-2-methyl-3-nitropyridine Chemical Properties,Uses,Production
Chemical Properties
Light yellow Cryst
Uses
6-Chloro-2-methyl-3-nitropyridine has been used as a reactant for the synthesis of fluorine-containing pyridinealdoxime derivatives as treatment of organophosphorus nerve-agent poisoning.
Preparation
A mixture of 2-oxo-5-nitro-6-methyl-1,2-dihydropyridine, phosphorous oxychloride, and phosphorous pentachloride was heated at 110° C for 2 hours, whereupon the reaction mixture was charged with an additional portion of phosphorous pentachloride and phosphorous oxychloride. The reaction was stirred for 1 hour and then poured into ice water. The brown solid was filtered and washed with cold water, to give 6-Chloro-2-methyl-3-nitropyridine (94%).
Synthesis
28489-45-4
22280-60-0
General procedure for the synthesis of 2-chloro-5-nitro-6-methylpyridine from 2-hydroxy-6-methyl-5-nitropyridine: 1. 2-Hydroxy-6-methyl-5-nitropyridine (500 mg, 3.24 mmol), phosphorus trichloride (POCl3, 0.5 mL) and phosphorus pentachloride (PCl5, 200 mg) were mixed and the reaction was stirred for 2 hours at 150 °C. After completion of the reaction, it was cooled to room temperature, the reaction mixture was poured into ice water and extracted with dichloromethane (DCM, 3 x 20 mL). The organic phases were combined, washed with water to pH 7, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The resulting residue was dried under reduced pressure to give 6-chloro-2-methyl-3-nitropyridine (430 mg, 78% yield) as a light brown solid. 2. 3-Ethynyl-7,7-dimethyl-7,8-dihydroquinolin-5(6H)-one (199 mg, 1.00 mmol) was mixed with 6-chloro-2-methyl-3-nitropyridine (172 mg, 1.00 mmol) in the presence of PdCl2(PPh3)2 (42 mg, 0.06 mmol), P(t-Bu)3 (16 mg , 0.08 mmol) and triethylamine (TEA, 1.5 mL) in a solution of N,N-dimethylformamide (DMF, 3 mL), and the reaction was stirred at 100 °C for 3 hours. The crude product was purified by silica gel column chromatography to afford the intermediate 7,7-dimethyl-3-((6-methyl-5-nitropyridin-2-yl)ethynyl)-7,8-dihydroquinolin-5(6H)-one (80 mg, 16% yield) as a yellow solid. 3. 7,7-Dimethyl-3-((6-methyl-5-nitropyridin-2-yl)ethynyl)-7,8-dihydroquinolin-5(6H)-one (194 mg, 0.58 mmol) was dissolved in ethyl acetate (EtOAc, 10 mL) and cooled to 0°C. A concentrated aqueous hydrochloric acid solution (1 mL) of stannous chloride dihydrate (SnCl2-2H2O, 650 mg, 2.90 mmol) was slowly added. The reaction mixture was stirred at room temperature for 3 h. The reaction mixture was poured into ice water, adjusted to pH 9-10 with 15% aqueous sodium hydroxide and extracted with ethyl acetate (EtOAc, 3 × 25 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The resulting residue was purified by preparative thin layer chromatography (silica gel, dichloromethane/ethanol, 40:1) to afford the target product 2-chloro-5-nitro-6-methylpyridine (34 mg, 19% yield). Product characterization: 1H NMR (DMSO-d6) δH: 1.05 (s, 6H), 2.29 (s, 3H), 2.59 (s, 2H), 3.03 (s, 2H), 5.51 (br s, 2H), 6.92 (d, 1H), 7.24 (d, 1H), 8.15 (s, 1H), 8.83 (s, 1H). LC/MS (M+H)+ = 306.
References
[1] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[2] Patent: WO2012/52451, 2012, A1. Location in patent: Page/Page column 113
[3] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0021
[4] Patent: WO2005/42464, 2005, A1. Location in patent: Page/Page column 33
[5] Journal of the American Chemical Society, 1952, vol. 74, p. 3828,3830
6-Chloro-2-methyl-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
View Lastest Price from 6-Chloro-2-methyl-3-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-20 | 6-Chloro-2-methyl-3-nitropyridine
22280-60-0
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-02-02 | 6-Chloro-2-methyl-3-nitropyridine
22280-60-0
|
$1.00 | 1g | 98% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-12-01 | 6-Chloro-2-methyl-3-nitropyridine
22280-60-0
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 6-Chloro-2-methyl-3-nitropyridine
22280-60-0
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 6-Chloro-2-methyl-3-nitropyridine
22280-60-0
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 6-Chloro-2-methyl-3-nitropyridine
22280-60-0
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
