2-Phenylpiperazine
- CAS No.
- 5271-26-1
- Chemical Name:
- 2-Phenylpiperazine
- Synonyms
- 2-Phenylpiperizine;2-PHENYLPIPERAZINE;m-phenylpiperazine;Piperazine, 2-phenyl-;2-Phenylpiperazine 97%;2-Phenylpiperazine ISO 9001：2015 REACH
- CBNumber:
- CB6734451
- Molecular Formula:
- C10H14N2
- Molecular Weight:
- 162.23
- MDL Number:
- MFCD01871362
- MOL File:
- 5271-26-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Phenylpiperazine 96% | 638641 | 5g | $136 |
| 2-Phenylpiperazine 96% | 638641 | 25g | $650 |
| 2-PhenyLpiperazine Asreported | 287568 | 5g | $475 |
| 2-PhenyLpiperazine Asreported | 287568 | 10g | $715 |
| 2-PhenyLpiperazine Asreported | 287568 | 25g | $1197 |
| More product size | |||
| Melting point | 83-87 °C (lit.) |
|---|---|
| Boiling point | 138 °C |
| Density | 0.997±0.06 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| form | solid |
| pka | 8.80±0.40(Predicted) |
| color | Yellow |
| InChI | 1S/C10H14N2/c1-2-4-9(5-3-1)10-8-11-6-7-12-10/h1-5,10-12H,6-8H2 |
| InChIKey | RIMRLBGNCLMSNH-UHFFFAOYSA-N |
| SMILES | C1CNC(CN1)c2ccccc2 |
| CAS DataBase Reference | 5271-26-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| RIDADR | UN3259 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Phenylpiperazine price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 638641 | 2-Phenylpiperazine 96% | 5271-26-1 | 5g | $136 | 2026-04-30 | Buy |
| Sigma-Aldrich | 638641 | 2-Phenylpiperazine 96% | 5271-26-1 | 25g | $650 | 2023-01-07 | Buy |
| Usbiological | 287568 | 2-PhenyLpiperazine Asreported | 5271-26-1 | 5g | $475 | 2026-06-03 | Buy |
| Usbiological | 287568 | 2-PhenyLpiperazine Asreported | 5271-26-1 | 10g | $715 | 2026-06-03 | Buy |
| Usbiological | 287568 | 2-PhenyLpiperazine Asreported | 5271-26-1 | 25g | $1197 | 2026-06-03 | Buy |
2-Phenylpiperazine Chemical Properties,Uses,Production
Uses
2-Phenylpiperazine is the starting material for the synthesis of 2-phenylpiperazine compounds. It has been synthesized 1,4-dimethyl-2-phenylpiperazine, 1,4-diethyl-2-phenyl Piperazine etc.
Synthesis
5368-28-5
5271-26-1
General procedure for the synthesis of 2-phenylpiperazine from 3-oxo-2-phenylpiperazine: 2-oxo-3-phenylpiperazine (1.76 g, 10 mmol) was dissolved in 30 mL of anhydrous THF and added slowly and dropwise to 20 mL (20 mmol) of a THF solution of 1M LiAlH4. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, water and 20% NaOH solution were carefully added to quench the excess LiAlH4. Subsequently, the reaction mixture was filtered and the filter cake was re-extracted with ethyl acetate. The organic filtrate and extract were combined, dried with MgSO4, filtered and concentrated under reduced pressure to give a light yellow solid. The crude product was further purified by silica gel column chromatography (eluent: CHCl3:MeOH:NH4OH = 9:1:0.1) to afford 2-phenylpiperazine (960 mg, 6 mmol, 60% yield) as a colorless solid. The product was characterized by 1H NMR (CDCl3): δ 2.69 (1H, t, J = 11.3 Hz), 2.85-3.10 (7H, m), 3.76 (1H, br d, J = 8.9 Hz), 7.21-7.38 (5H, m). Melting point determination (capillary method): 79-81°C.
References
[1] Patent: WO2004/63150, 2004, A2. Location in patent: Page 28-29
[2] Patent: US2005/222166, 2005, A1. Location in patent: Page/Page column 13
[3] Patent: EP1396487, 2004, A1. Location in patent: Page 17-18
2-Phenylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28509 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 9796 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
View Lastest Price from 2-Phenylpiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2-Phenylpiperazine
5271-26-1
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-07-07 | 2-Phenylpiperazine
5271-26-1
|
1KG | 90%-99.9% | 500kg | Career Henan Chemical Co |
-
- 2-Phenylpiperazine
5271-26-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Phenylpiperazine
5271-26-1
- $0.00
- 90%-99.9%
- Career Henan Chemical Co
5271-26-1(2-Phenylpiperazine)Related Search:
1of4
