Trifluoroacetic anhydride
- CAS No.
- 407-25-0
- Chemical Name:
- Trifluoroacetic anhydride
- Synonyms
- TFAA;2,2,2-Trifluoroacetic anhydride;trifluoroacetic;TRIFLUOROACETIC ACID ANHYDRIDE;TRIFLUORACETIC ANHYDRIDE;TIFLUOROACETIC ANHYDRIDE;Trifluoroacetic anhy;Trifluoroacetic anhydride 10g [407-25-0];trimethylamine (TMA);uoroacetic anhydride
- CBNumber:
- CB6853606
- Molecular Formula:
- C4F6O3
- Molecular Weight:
- 210.03
- MDL Number:
- MFCD00000416
- MOL File:
- 407-25-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Trifluoroacetic anhydride for synthesis | 8.08261 | 25mL | $47.8 |
| Trifluoroacetic anhydride for synthesis | 8.08261 | 100mL | $125 |
| Trifluoroacetic anhydride ReagentPlus , ≥99% | 106232 | 10x1g | $235 |
| Trifluoroacetic anhydride for synthesis | 8.08261 | 500mL | $498 |
| Trifluoroacetic anhydride ReagentPlus , ≥99% | 106232 | 3kg | $1620 |
| More product size | |||
| Melting point | -65 °C (lit.) |
|---|---|
| Boiling point | 39.5-40 °C (lit.) |
| Density | 1.511 g/mL at 20 °C (lit.) |
| vapor pressure | 6.28 psi ( 20 °C) |
| refractive index |
n |
| Flash point | -26 °C |
| storage temp. | 2-8°C |
| solubility | Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile. |
| form | Liquid |
| pka | 0.43[at 20 ℃] |
| Specific Gravity | 1.487 |
| color | Clear |
| Water Solubility | Hydrolysis |
| Sensitive | Moisture Sensitive |
| BRN | 746197 |
| Stability | Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents. |
| InChI | 1S/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10 |
| InChIKey | QAEDZJGFFMLHHQ-UHFFFAOYSA-N |
| SMILES | FC(F)(F)C(=O)OC(=O)C(F)(F)F |
| LogP | 0.79 at 25℃ |
| CAS DataBase Reference | 407-25-0(CAS DataBase Reference) |
| FDA UNII | 5ENA87IZHT |
| NIST Chemistry Reference | Acetic acid, trifluoro-, anhydride(407-25-0) |
| EPA Substance Registry System | Acetic acid, trifluoro-, anhydride (407-25-0) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H314-H412-H290 | |||||||||
| Precautionary statements | P501-P261-P273-P270-P234-P271-P264-P280-P390-P362+P364-P303+P361+P353-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P406-P405 | |||||||||
| PPE | Faceshields, Gloves, Goggles | |||||||||
| Hazard Codes | C,T | |||||||||
| Risk Statements | 14-20-35-52/53-34-23/24/25 | |||||||||
| Safety Statements | 26-36/37/39-43-45-61-9-8-28A-27 | |||||||||
| RIDADR | UN 3265 8/PG 1 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AJ9800000 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Corrosive/Moisture Sensitive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29159080 | |||||||||
| Storage Class | 8B - Non-combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Inhalation Aquatic Chronic 3 Eye Dam. 1 Skin Corr. 1A |
|||||||||
| Toxicity | skn-rbt 500 mg/24H SEV 28ZPAK -,91,72 | |||||||||
| REACH Registrations | Active | |||||||||
| Excepted Quantities | Not Permitted as Excepted Quantity | |||||||||
| NFPA 704 |
|
Trifluoroacetic anhydride price More Price(93)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.08261 | Trifluoroacetic anhydride for synthesis | 407-25-0 | 25mL | $47.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.08261 | Trifluoroacetic anhydride for synthesis | 407-25-0 | 100mL | $125 | 2026-04-30 | Buy |
| Sigma-Aldrich | 106232 | Trifluoroacetic anhydride ReagentPlus , ≥99% | 407-25-0 | 10x1g | $235 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.08261 | Trifluoroacetic anhydride for synthesis | 407-25-0 | 500mL | $498 | 2026-04-30 | Buy |
| Sigma-Aldrich | 106232 | Trifluoroacetic anhydride ReagentPlus , ≥99% | 407-25-0 | 3kg | $1620 | 2026-04-30 | Buy |
Trifluoroacetic anhydride Chemical Properties,Uses,Production
Description
Trifluoroacetic acid anhydride (TFAA), a perfluoroacylated acylation reagent, forms stable, volatile derivatives with alcohols, amines, and phenols.
Chemical Properties
Clear, colorless liquid
Uses
Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Uses
Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.
Preparation
Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C.
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications
Safety Profile
A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit
Purification Methods
Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]
Trifluoroacetic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
1of8
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-86-17392712697 +8617792793228 | 1069@dideu.com | China | 8609 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
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View Lastest Price from Trifluoroacetic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-21 | Trifluoroacetic anhydride
407-25-0
|
1KG | 99% | 500mt | Jinan Finer Chemical Co., Ltd | ||
 |
2026-05-15 | Trifluoroacetic anhydride
407-25-0
|
$1.10 | 1g | 99.0% Min | 100 Tons | Shaanxi Didu New Materials Co. Ltd | |
 |
2026-03-20 | Trifluoroacetic anhydride
407-25-0
|
$19.90 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Trifluoroacetic anhydride
407-25-0
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Trifluoroacetic anhydride
407-25-0
- $1.10
- 99.0% Min
- Shaanxi Didu New Materials Co. Ltd
-
- Trifluoroacetic anhydride
407-25-0
- $19.90
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
