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MECLOFENAMATE SODIUM

MECLOFENAMATE SODIUM structure

CAS No.: 6385-02-0

Chemical Name:: MECLOFENAMATE SODIUM

Synonyms: Meclofenamate;ci583;C02996;Movens;meclomen;Meclonax;SODIUM MECLOFENAMATE;MECLOFENAMATE SODIUM;sodiummeclophenamate;MECLOFENAMATESODIUM,USP

CBNumber:: CB7102365

Molecular Formula:: C14H10Cl2NO2.Na

Molecular Weight:: 318.13

MDL Number:: MFCD00941475

MOL File:: 6385-02-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:13:30

Product description	Number	Pack Size	Price
Meclofenamate Sodium pharmaceutical secondary standard, certified reference material	PHR3201	1g	$216
Meclofenamate Sodium United States Pharmacopeia (USP) Reference Standard	1377803	500mg	$441
Meclofenamic acid sodium salt	M4531	1g	$58.2
Sodium Meclofenamate	M1269	1G	$63
Sodium Meclofenamate Hydrate >98.0%(HPLC)(N)	M1269	10g	$372
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MECLOFENAMATE SODIUM Properties

Melting point	287-291 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	White solid.
color	White to Off-White
biological source	synthetic (organic)
Water Solubility	Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
Merck	14,5779
Stability	Hygroscopic
Major Application	pharmaceutical
InChI	1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
InChIKey	CHGIZYUDGOIAFY-UHFFFAOYSA-N
SMILES	[Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
FDA UNII	9MMQ0YER4E
NCI Drug Dictionary	meclofenamate sodium
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

WGK Germany

RTECS

CB2975500

HS Code

2922498050

Storage Class

11 - Combustible Solids

NFPA 704

	0
3		0

MECLOFENAMATE SODIUM price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3201	Meclofenamate Sodium pharmaceutical secondary standard, certified reference material	6385-02-0	1g	$216	2026-04-30	Buy
Sigma-Aldrich	1377803	Meclofenamate Sodium United States Pharmacopeia (USP) Reference Standard	6385-02-0	500mg	$441	2026-04-30	Buy
Sigma-Aldrich	M4531	Meclofenamic acid sodium salt	6385-02-0	1g	$58.2	2025-07-31	Buy
TCI Chemical	M1269	Sodium Meclofenamate	6385-02-0	1G	$63	2026-04-30	Buy
TCI Chemical	M1269	Sodium Meclofenamate Hydrate >98.0%(HPLC)(N)	6385-02-0	10g	$372	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHR3201	1g	$216	Buy
1377803	500mg	$441	Buy
M4531	1g	$58.2	Buy
M1269	1G	$63	Buy
M1269	10g	$372	Buy

MECLOFENAMATE SODIUM Chemical Properties,Uses,Production

Description

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC₅₀ values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC₅₀ is much lower if pre-incubated with the enzyme.

Originator

Meclomen,Warner Lambert,US,1980

Uses

antiinflammatory, antipyretic

Uses

Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.

Definition

ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.

Indications

Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.

Manufacturing Process

A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.

brand name

Meclomen (Parke-Davis).

Therapeutic Function

Antiinflammatory

General Description

Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.

Pharmacokinetics

Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
Metabolism of meclofenamic acid..jpg

Clinical Use

Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.

MECLOFENAMATE SODIUM Preparation Products And Raw materials

Raw materials

2,6-Dichloro-3-methylaniline N-Ethylmorpholine

Preparation Products

MECLOFENAMATE SODIUM Suppliers

Global( 155)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20582	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15083	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49969	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58

Supplier	Advantage
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from MECLOFENAMATE SODIUM manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-11	Meclofenamic acid sodium 6385-02-0	$33.00-77.00		98.00%	10g	TargetMol Chemicals Inc.
2026-04-20	Meclofenamic acid sodium 6385-02-0	$33.00-77.00		98.00%	10g	TargetMol Chemicals Inc.
2025-12-01	Meclofenamic acid sodium salt 6385-02-0		1KG	98%	10000kg	Shaanxi Dideu New Materials Co. Ltd

Meclofenamic acid sodium
6385-02-0
$33.00-77.00
98.00%
TargetMol Chemicals Inc.

Meclofenamic acid sodium
6385-02-0
$33.00-77.00
98.00%
TargetMol Chemicals Inc.

Meclofenamic acid sodium salt
6385-02-0
98%
Shaanxi Dideu New Materials Co. Ltd

MECLOFENAMATE SODIUM Spectrum

MECLOFENAMATE SODIUM(6385-02-0)¹HNMR MECLOFENAMATE SODIUM(6385-02-0)¹³CNMR MECLOFENAMATE SODIUM(6385-02-0)IR1 MECLOFENAMATE SODIUM(6385-02-0)IR2

6385-02-0(MECLOFENAMATE SODIUM)Related Search:

MCPA SODIUM CLOFENAMIC ACID SODIUM ANTHRANILATE Meclofenamic acid MECLOFENAMATE SODIUM

N-Phenylanthranilic acid 2,6-DICHLORODIPHENYLAMINE 2-Chloro-5-methylaniline 2,6-Dichloro-3-methylaniline 2-Chloro-m-toluidine.

N-(2-CHLOROPHENYL)ANTHRANILIC ACID N-(3-METHYLPHENYL)ANTHRANILIC ACID 2-[(2-Chlorophenyl)amino]-benzaldehyde 2-[(2,6-dichlorophenyl)amino]benzoicacid (2-CHLORO-PHENYL)-PHENYL-AMINE

(2-(2,6-DICHLOROANILINO)PHENYL) METHANOL 2-(2,6-Dichloroanilino) benzaldehyde MECLOFENAMATE SODIUM USP(CRM STANDARD)

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MECLOFENAMIC ACID SODIUM SALT MONOHYDRATE Sodium Meclofenamate Monohydrate C02996 SODIUM MECLOFENAMATE meclofenamic acid sodium MECLOFENAMIC ACID SODIUM SALT 99% MECLOFENAMATESODIUM,USP sodium meclofenamate (anhydrous) sodium2-((2,6-dichloro-3-methylphenyl)amino)benzoate sodiummeclophenamate MECLOFENAMATE SODIUM MECLOFENAMATE SODIUM HYDRATE MECLOFENAMATE SODIUM SALT MECLOFENAMIC ACID SODIUM SALT 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]-BENZOIC ACID, MONOSODIUM SALT 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]BENZOIC ACID SODIUM SALT sodium,2-(2,6-dichloro-3-methylanilino)benzoate 2-((2,6-dichloro-3-methylphenyl)amino)-benzoicacimonosodiumsalt ci583 meclomen n-(2,6-dichloro-m-tolyl)-anthranilicacimonosodiumsalt Benzoic acid, 2-[(2,6-dichloro-3-Methylphenyl)aMino]-, sodiuM salt Meclofenamate Sodium (500 mg) 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic Acid Sodium Salt Meclofenamic Acid Sodium Salt SodiuM MeclofenaMate Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt (1:1) 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, sodium salt (1:1) Sodium Meclofenamate Hydrate sodium 2-(2,6-dichloro-3-methylanilino)benzoate hydrate SodiumMeclofenamateMonohydrate> Meclonax Movens 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt monohydrate MECLOFENAMATE SODIUM USP/EP/BP Meclofenamate Sodium (Meclofenamic acid sodium) Meclofenamate Sodium (1377803) Endogenous Metabolite,Meclofenamate,Inhibitor,Meclofenamic acid sodium,inhibit,Meclofenamic acid,Gap Junction Protein Sodium Meclofenamate Monohydrate, ≥ 98.0% Meclofenamic acid sodium, 10 mM in DMSO Meclofenamate 6385-02-0 6358-02-0 C14H10Cl2NO2NaH2O C14H10Cl2NNaO2H2O C14H10Cl2NNaO2xH2O C14H11Cl2NNaO2 Lipoxygenase (5-) and cyclooxygenase L to O Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates BioChemical Biochemicals and Reagents MECLOMEN

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MECLOFENAMATE SODIUM

MECLOFENAMATE SODIUM Properties

SAFETY

Risk and Safety Statements

MECLOFENAMATE SODIUM price More Price(72)

MECLOFENAMATE SODIUM Chemical Properties,Uses,Production

Description

Originator

Uses

Uses

Definition

Indications

Manufacturing Process

brand name

Therapeutic Function

General Description

Pharmacokinetics

Clinical Use

MECLOFENAMATE SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

MECLOFENAMATE SODIUM Suppliers

View Lastest Price from MECLOFENAMATE SODIUM manufacturers

MECLOFENAMATE SODIUM Spectrum

6385-02-0(MECLOFENAMATE SODIUM)Related Search: