Pseudouridine
- CAS No.
- 1445-07-4
- Chemical Name:
- Pseudouridine
- Synonyms
- PSEUDOURIDINE;Pseudo-UTP;β-Pseudouridine;5-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;5-Ribosyluracil;y-Uridine;NSC 162405;Pseudoruidine;Pseudourindine;Pseudouricdine
- CBNumber:
- CB7125832
- Molecular Formula:
- C9H12N2O6
- Molecular Weight:
- 244.2
- MDL Number:
- MFCD00038458
- MOL File:
- 1445-07-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pseudouridine ≥98% | SMB00912 | 25mg | $74.5 |
| Pseudouridine ≥98% | SMB00912 | 100mg | $250 |
| Pseudouridine (Synthetic) | P2939 | 100MG | $154 |
| Pseudouridine >98.0%(HPLC) | P2396 | 50mg | $393 |
| β-Pseudouridine ≥95% | 23383 | 5mg | $107 |
| More product size | |||
| Melting point | 222 °C |
|---|---|
| Density | 1.641±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Very Slightly, Heated), Water (Slightly, Sonicated, Heated) |
| pka | 8.52±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| PH | ～9.0 |
| biological source | synthetic (chemical) |
| Water Solubility | water: soluble |
| λmax | 264nm(MeOH)(lit.) |
| InChI | InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/s3 |
| InChIKey | PTJWIQPHWPFNBW-IZFRNLNUNA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O)O |&1:1,2,3,7,r| |
| FDA UNII | 7R0R6H6KEG |
| UNSPSC Code | 41106305 |
| NACRES | NA.79 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| HS Code | 2934.99.9001 |
| Storage Class | 13 - Non Combustible Solids |
Pseudouridine price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00912 | Pseudouridine ≥98% | 1445-07-4 | 25mg | $74.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | SMB00912 | Pseudouridine ≥98% | 1445-07-4 | 100mg | $250 | 2026-04-30 | Buy |
| TCI Chemical | P2939 | Pseudouridine (Synthetic) | 1445-07-4 | 100MG | $154 | 2026-04-30 | Buy |
| TCI Chemical | P2396 | Pseudouridine >98.0%(HPLC) | 1445-07-4 | 50mg | $393 | 2026-04-30 | Buy |
| Cayman Chemical | 23383 | β-Pseudouridine ≥95% | 1445-07-4 | 5mg | $107 | 2026-04-30 | Buy |
Pseudouridine Chemical Properties,Uses,Production
Description
β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine. It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. Pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.
Uses
An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
Definition
ChEBI: Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite.
Origin
Pseudouridine (Ψ) was the first modified ribonucleotide discovered 7 decades ago, and it has been found in tRNA, rRNA, snRNA, mRNA, and other types of RNA[2].
Biochem/physiol Actions
Pseudouridine is essential for rRNA folding and for regulating translational accuracy and it is required for stabilizing the tRNA structure. Pseudouridine in rRNA and tRNA has been shown to fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation. Pseudouridine in snRNA has been shown to enhance spliceosomal RNA-pre-mRNA interaction to facilitate splicing regulation[1].
target
Human Endogenous Metabolite
Structure and conformation
Pseudouridine, being one of them, is the C5-glycoside isomer of uridine that contains a C-C bond between C1 of the ribose sugar and C5 of uracil, rather than usual C1-N1 bond found in uridine. The C-C bond gives it more rotational freedom and conformational flexibility.In addition, pseudouridine has an extra hydrogen bond donor at the N1 position.
References
[1] Mingjia Chen, Claus-Peter Witte. “A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation.” Plant Cell 32 3 (2020): 722–739.
[2] Pedro Morais, Yi-Tao Yu, Hironori Adachi. “The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines.” Frontiers in Cell and Developmental Biology (2021): 789427.
Pseudouridine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +86-18055326116 | sales1@nuowei-chem.com | China | 1627 | 58 |
| SHANGHAI NOVRIBO BIOTECH | 17821030819 | June.Liu@Desano.com | China | 73 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 302 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
Related articles
- Pseudouridine: Evolution and Functions
- Pseudouridine, discovered in the 1950s, plays vital roles across various RNA types, influencing RNA integrity, ribosome functi....
- Mar 21，2024
- Pseudouridine: Application and Pharmacology, Synthesis, Toxicity and safety
- Pseudouridine (Ψ；5-ribosyluracil) is a C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue att....
- Mar 27，2023
View Lastest Price from Pseudouridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | Pseudouridine
1445-07-4
|
$800.00-999.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-07-24 | Pseudouridine
1445-07-4
|
1g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-21 | Pseudouridine
1445-07-4
|
$30.00-93.00 | 99.69% | 10g | TargetMol Chemicals Inc. |
-
- Pseudouridine
1445-07-4
- $800.00-999.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Pseudouridine
1445-07-4
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Pseudouridine
1445-07-4
- $30.00-93.00
- 99.69%
- TargetMol Chemicals Inc.
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