3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
- CAS No.
- 376592-93-7
- Chemical Name:
- 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
- Synonyms
- 3'-Amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid;EltroMbopag I;ltrombopag Impurity; ltrombopag Impurity 9;Eltrombopag Intermediate 2;DarunavirDiamino(2S,3R)Isomer;Eltrombopag Impurity 40 Monomer;Eltrombopag olamine Intermediate 1;-Biphenyl]-3-carboxylicacid, 3'3-(3-amino-2-hydroxyphenyl)benzoicaci
- CBNumber:
- CB71502104
- Molecular Formula:
- C13H11NO3
- Molecular Weight:
- 229.23
- MDL Number:
- MFCD10001467
- MOL File:
- 376592-93-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid >98.0%(HPLC)(T) | A2944 | 200mg | $66 |
| 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid >98.0%(HPLC)(T) | A2944 | 1g | $244 |
| 3’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid | TRC-A611255-250MG | 250mg | $131 |
| 3’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid | TRC-A611255-2.5G | 2.5g | $450 |
| 3’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid Asreported | 160842 | 250mg | $509 |
| More product size | |||
| Melting point | 222 °C(dec.) |
|---|---|
| Boiling point | 474.8±45.0 °C(Predicted) |
| Density | 1.364 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 3.99±0.10(Predicted) |
| color | Pale Yellow to Light Brown |
| InChI | InChI=1S/C13H11NO3/c14-11-6-2-5-10(12(11)15)8-3-1-4-9(7-8)13(16)17/h1-7,15H,14H2,(H,16,17) |
| InChIKey | ZXLYSSHNDUXXIN-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=CC(N)=C2O)=CC=CC(C(O)=O)=C1 |
| FDA UNII | 2GS5685MP9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2922.50.5000 |
3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2944 | 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid >98.0%(HPLC)(T) | 376592-93-7 | 200mg | $66 | 2026-04-30 | Buy |
| TCI Chemical | A2944 | 3'-Amino-2'-hydroxybiphenyl-3-carboxylic Acid >98.0%(HPLC)(T) | 376592-93-7 | 1g | $244 | 2023-06-20 | Buy |
| TRC | TRC-A611255-250MG | 3’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid | 376592-93-7 | 250mg | $131 | 2026-06-03 | Buy |
| TRC | TRC-A611255-2.5G | 3’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid | 376592-93-7 | 2.5g | $450 | 2026-06-03 | Buy |
| Usbiological | 160842 | 3’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid Asreported | 376592-93-7 | 250mg | $509 | 2026-06-03 | Buy |
3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
3’-Amino-2’-Hydroxy-[1,1’]Biphenyl-3-carboxylic Acid is used in the synthesis of monoethanolamine salts. A hydrazine cleavage product from Eltrombopag (E508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia
Synthesis
376592-58-4
376592-93-7
The general procedure for the synthesis of 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid from 5'-chloro-2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid is as follows: 5'-chloro-2'-hydroxy-3'-nitro-biphenyl-3-carboxylic acid (Compound 2b) (5.0 g) was dissolved in a methanol (MeOH) (300 mL) and triethylamine (Et3N) (4.75 mL) in a solvent mixture. A palladium/carbon (Pd/C) catalyst (0.5 g) was added to the solution, followed by hydrogenation at room temperature and 10 bar hydrogen pressure for 21 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to dryness. The obtained residue was dissolved in water (40 mL) and the pH was adjusted to 5.5 by dropwise addition of 0.5 M hydrochloric acid (HCl). the resulting suspension was stirred at room temperature for 30 min, followed by filtration. The collected solid product was washed with water (2 x 10 mL) and finally dried at 50 °C/50 mbar to afford the target product 3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid (BPCA) (3.4 g; yield 86.7%; HPLC purity 97.9%).
References
[1] Patent: WO2013/49605, 2013, A1. Location in patent: Paragraph 0058
3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Maison Chemical Co.,Ltd. | +8615511852758 | sales@maisonchem.com.cn | China | 484 | 58 |
| Shanghai Joiny Pharmaceutical Co.,LTD | +86-13681955282 +86-13681955282; | gyd@joiny-pharma.com | China | 402 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3016 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14014 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21586 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
View Lastest Price from 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-08 | 3-(3-Amino-2-hydroxyphenyl)benzoic Acid
376592-93-7
|
1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. | ||
 |
2026-05-05 | 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
376592-93-7
|
$70.00-700.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2026-01-04 | 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
376592-93-7
|
1kg | 99% | 500KG | Hangzhou ICH Biofarm Co., Ltd |
-
- 3-(3-Amino-2-hydroxyphenyl)benzoic Acid
376592-93-7
- 99%
- Jinan Ruitong Biotech Co., Ltd.
-
- 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
376592-93-7
- $70.00-700.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- 3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
376592-93-7
- 99%
- Hangzhou ICH Biofarm Co., Ltd
