5-FLUOROINDOLE-3-CARBOXYLIC ACID
- CAS No.
- 23077-43-2
- Chemical Name:
- 5-FLUOROINDOLE-3-CARBOXYLIC ACID
- Synonyms
- 5-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID;RARECHEM AL BE 0942;5-fluoro-indol-3-carboxylic acid;5-FLUOROINDOLE-3-CARBOXYLIC ACID;5-Fluoro-1H-indol-3-carboxylic acid;1H-INDOLE-3-CARBOXYLIC ACID,5-FLUORO
- CBNumber:
- CB7165041
- Molecular Formula:
- C9H6FNO2
- Molecular Weight:
- 179.15
- MDL Number:
- MFCD00047171
- MOL File:
- 23077-43-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Fluoro-1H-indole-3-carboxylic acid 95% | PC201206 | 100mg | $21 |
| 5-Fluoro-1H-indole-3-carboxylic acid 95% | PC201206 | 250mg | $24 |
| 5-Fluoro-1H-indole-3-carboxylic acid 95% | PC201206 | 1g | $26 |
| 5-Fluoro-1H-indole-3-carboxylic acid 95% | PC201206 | 5g | $123 |
| 5-Fluoro-1H-indole-3-carboxylic acid 95% | PC201206 | 25g | $607 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
5-FLUOROINDOLE-3-CARBOXYLIC ACID price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC201206 | 5-Fluoro-1H-indole-3-carboxylic acid 95% | 23077-43-2 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC201206 | 5-Fluoro-1H-indole-3-carboxylic acid 95% | 23077-43-2 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC201206 | 5-Fluoro-1H-indole-3-carboxylic acid 95% | 23077-43-2 | 1g | $26 | 2026-06-04 | Buy |
| Apolloscientific | PC201206 | 5-Fluoro-1H-indole-3-carboxylic acid 95% | 23077-43-2 | 5g | $123 | 2026-06-04 | Buy |
| Apolloscientific | PC201206 | 5-Fluoro-1H-indole-3-carboxylic acid 95% | 23077-43-2 | 25g | $607 | 2026-06-04 | Buy |
5-FLUOROINDOLE-3-CARBOXYLIC ACID Chemical Properties,Uses,Production
Application
5-Fluoroindole-3-carboxylic acid can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.
Synthesis
1260793-83-6
23077-43-2
General procedure for the synthesis of 5-fluoro-1H-indole-3-carboxylic acid from 2,2,2-trifluoro-1-(5-fluoro-1H-indol-3-yl)ethanone: 2,2,2-trifluoro-1-[5-fluoro-1-(pyrimidin-2-yl)-1H-indol-3-yl]ethan-1-one (1.6 g) and 5 N aqueous sodium hydroxide were added to the reaction flask. The reaction mixture was stirred under heated reflux conditions for 1.5 hours. After completion of the reaction, the reaction solution was cooled to room temperature and extracted by adding water and ethyl acetate. After separating the organic and aqueous layers, the aqueous layer was made acidic with concentrated hydrochloric acid. The acidic aqueous layer was again extracted with ethyl acetate, the organic layers were combined and washed with saturated saline. The organic layer was dried with anhydrous sodium sulfate and the solvent was removed by distillation under reduced pressure to give 785 mg of 5-fluoro-1H-indole-3-carboxylic acid (88% yield).
References
[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 17, p. 7293 - 7316
[2] Patent: EP2548864, 2013, A1. Location in patent: Paragraph 0178; 0179
[3] Patent: WO2013/14102, 2013, A1. Location in patent: Page/Page column 26; 32; 33
[4] Patent: JP2017/171619, 2017, A. Location in patent: Paragraph 0168; 0170
5-FLUOROINDOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
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