(R)-1-N-Boc-beta-proline
- CAS No.
- 72925-16-7
- Chemical Name:
- (R)-1-N-Boc-beta-proline
- Synonyms
- (S)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid;B67255;BOC-L-B-PROLINE;Boc-D-beta-Proline;(3S)-BOC-BETA-PRO-OH;N-Boc-D-beta-proline;(R)-N-Boc-Beta-Proline;N-Boc-D-^b-proline, 95%;(R)-1-N-Boc-beta-proline;(S)-1-N-BOC-BETA-PROLINE
- CBNumber:
- CB7225932
- Molecular Formula:
- C10H17NO4
- Molecular Weight:
- 215.25
- MDL Number:
- MFCD03094727
- MOL File:
- 72925-16-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (R)-1-Boc-3-pyrrolidinecarboxylic acid 97% | 735493 | 500mg | $152 |
| (R)-1-N-BOC-BETA-PROLINE 95% | 55858 | 1G | $47 |
| (R)-1-N-BOC-BETA-PROLINE 95% | 55858 | 5G | $140 |
| (R)-1-N-BOC-BETA-PROLINE 95% | 55858 | 25G | $575 |
| (3R)-1-tert-Butoxycarbonylpyrrolidine-3-carboxylic acid >97% | OR307104 | 250mg | $21 |
| More product size | |||
| Melting point | 138-143°C |
|---|---|
| Boiling point | 337.2±35.0 °C(Predicted) |
| Density | 1.201±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in Dimethyl sulfoxide (DMSO). |
| pka | 4.47±0.20(Predicted) |
| form | solid |
| color | White to off-white |
| optical activity | [α]/D -15.0, c = 0.5% in chloroform |
| InChI | InChI=1S/C10H17NO4/c1-10(2,3)15-9(14)11-5-4-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m1/s1 |
| InChIKey | HRMRQBJUFWFQLX-SSDOTTSWSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CC[C@@H](C(O)=O)C1 |
| CAS DataBase Reference | 72925-16-7(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H400 | |||||||||
| Precautionary statements | P273 | |||||||||
| Hazard Codes | N | |||||||||
| Risk Statements | 36/37/38-50 | |||||||||
| Safety Statements | 26-36/37/39-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Acute 1 | |||||||||
| NFPA 704 |
|
(R)-1-N-Boc-beta-proline price More Price(99)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 735493 | (R)-1-Boc-3-pyrrolidinecarboxylic acid 97% | 72925-16-7 | 500mg | $152 | 2026-04-30 | Buy |
| AstaTech | 55858 | (R)-1-N-BOC-BETA-PROLINE 95% | 72925-16-7 | 1G | $47 | 2026-04-30 | Buy |
| AstaTech | 55858 | (R)-1-N-BOC-BETA-PROLINE 95% | 72925-16-7 | 5G | $140 | 2026-04-30 | Buy |
| AstaTech | 55858 | (R)-1-N-BOC-BETA-PROLINE 95% | 72925-16-7 | 25G | $575 | 2026-04-30 | Buy |
| Apolloscientific | OR307104 | (3R)-1-tert-Butoxycarbonylpyrrolidine-3-carboxylic acid >97% | 72925-16-7 | 250mg | $21 | 2026-06-04 | Buy |
(R)-1-N-Boc-beta-proline Chemical Properties,Uses,Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Synthesis
122684-33-7
72925-16-7
General procedure for the synthesis of (R)-1-Boc-3-carboxypyrrolidine from methyl 1-Boc-pyrrolidine-3-carboxylate: sodium hydroxide (0.80 g, 20.00 mmol) was dissolved in water (15 mL), and this solution was added to a methanol (30 mL) solution of methyl 1-Boc-pyrrolidine-3-carboxylate (2.30 g, 10.00 mmol). . The reaction mixture was allowed to react for 3 hours with stirring at room temperature. After the reaction was completed, the methanol was removed by concentration under reduced pressure. The pH of the remaining solution was adjusted to 4 with 2 M glacial acetic acid and then extracted with dichloromethane (50 mL x 3). The organic phases were combined and dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 1.80 g of an oily product in 83.00% yield.
References
[1] Organic Letters, 2005, vol. 7, # 15, p. 3287 - 3289
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
[3] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[4] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0453; 0454; 0455
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059
(R)-1-N-Boc-beta-proline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
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