9-Fluorenylmethyl chloroformate
- CAS No.
- 28920-43-6
- Chemical Name:
- 9-Fluorenylmethyl chloroformate
- Synonyms
- FMOC-CL;FoMc-Cl;(9H-fluoren-9-yl)Methyl carbonochloridate;FMOC-C;fmoc-ci;9-FLUORENYLMETHOXYCARBONYL CHLORIDE;FMOC-CHLORIDE;9-Fluorenylmethyl;FMOC-C1;Fluorenylmethyloxycarbonyl chloride
- CBNumber:
- CB7234569
- Molecular Formula:
- C15H11ClO2
- Molecular Weight:
- 258.7
- MDL Number:
- MFCD00001138
- MOL File:
- 28920-43-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (9-Fluorenylmethyl) chloroformate Novabiochem? | 8.52259 | 25g | $59.6 |
| (9-Fluorenylmethyl) chloroformate for synthesis | 8.18203 | 500mg | $37.4 |
| (9-Fluorenylmethyl) chloroformate Novabiochem? | 8.52259 | 100g | $168 |
| (9-Fluorenylmethyl) chloroformate for synthesis | 8.18203 | 5G | $127 |
| (9-Fluorenylmethyl) chloroformate for synthesis | 8.18203 | 25g | $327 |
| More product size | |||
| Melting point | 62-64 °C(lit.) |
|---|---|
| Boiling point | 365.79°C (rough estimate) |
| Density | 1.1780 (rough estimate) |
| refractive index | 1.5330 (estimate) |
| storage temp. | 2-8°C |
| solubility | dioxane: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| color | White to very pale yellow |
| Sensitive | Moisture Sensitive |
| BRN | 2279177 |
| Stability | Hygroscopic, Moisture Sensitive |
| InChI | InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2 |
| InChIKey | IRXSLJNXXZKURP-UHFFFAOYSA-N |
| SMILES | C(Cl)(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
| LogP | 3.45 |
| CAS DataBase Reference | 28920-43-6(CAS DataBase Reference) |
| FDA UNII | 9PLB0BTT90 |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C,T | |||||||||
| Risk Statements | 34-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LQ6250000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | No | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159020 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
9-Fluorenylmethyl chloroformate price More Price(131)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.52259 | (9-Fluorenylmethyl) chloroformate Novabiochem? | 28920-43-6 | 25g | $59.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.18203 | (9-Fluorenylmethyl) chloroformate for synthesis | 28920-43-6 | 500mg | $37.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.52259 | (9-Fluorenylmethyl) chloroformate Novabiochem? | 28920-43-6 | 100g | $168 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.18203 | (9-Fluorenylmethyl) chloroformate for synthesis | 28920-43-6 | 5G | $127 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.18203 | (9-Fluorenylmethyl) chloroformate for synthesis | 28920-43-6 | 25g | $327 | 2026-04-30 | Buy |
9-Fluorenylmethyl chloroformate Chemical Properties,Uses,Production
Description
9-Fluorenylmethyl chloroformate (Fmoc-C1) is a significant biochemical reagent introduced by Carpino. It has been widely utilized as a reagent for the introduction of the 9-fluorenylmethoxycarbonyl (Fmoc moiety) in both peptide and nucleotide synthesis, as well as serving as a coupling agent in peptide synthesis[1]. Furthermore, Fmoc-C1 can function as a versatile fluorescent labeling reagent for primary and secondary amines[2].
Chemical Properties
9-Fluorenyl chloroformate appears as white crystals with a melting point of 62–64 °C. It is soluble in organic solvents such as CH?Cl?, THF, and dioxane. It reacts with alcohols, ammonia or amines, and water.
Uses
9-Fluorenylmethyl chloroformate can be used as N-protecting reagent for oligonucleotide and peptide syntheses. It can act as reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions.
Uses
9-Fluorenylmethyl chloroformate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).
General Description
Fmoc chloride is a derivatizing agent.
Flammability and Explosibility
Not classified
Safety Profile
A poison. Mutation data reported. A corrosive. When heated to decomposition it emits toxic vapors of Cl-.
Purification Methods
If the IR contains no OH bands (at ~3000 cm-1) due to the hydrolysis product 9-fluorenylmethanol, then purify it by recrystallisation from dry Et2O. IR (CHCl3) has a band at 1770 cm-1 (C=O), and the NMR (CDCl3) has at 4-4.6 (m 2H, CHCH2) and 7.1-7.8 (m, 8 aromatic H) ppm. The azide (FMOC-N3) has m 89-90o (from -1hexane) and IR (CHCl3) at 2135 (N3) and 1730 (C=O) cm , and the carbazate (FMOC-NHNH2) has m 171o(dec) (from nitromethane), IR (KBr) 3310, 3202 (NH) and 1686 (CONH) cm-1. [Caprino & Han J Org Chem 37, 3404 1972 , J Am Chem Soc 92 5748 1970, Koole et al. J Org Chem 59 1657 1989, Fürst et al. J Chromatogr 499 537 1990.]
References
[1] S. TANTRY; V. V B; G Vasanthakumar. Synthesis of peptides employing 9-fluorenylmethyl chloroformate as a coupling agent[J]. Letters in peptide science: LIPS, 2006, 10 1: 51-55. DOI:10.1007/BF02443642.
[2] H. A. MOYE A. B. A Versatile Fluorogenic Labelling Reagent for Primary and Secondary Amines: 9-Fluorenylmethyl Chloroformate[J]. Analytical Letters, 1979, 12 1: 25-35. DOI:10.1080/00032717908082516.
9-Fluorenylmethyl chloroformate Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 491 | 58 |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
| Zepeptide Biotechnology (Shijiazhuang) Co., Ltd | +86-86-13383293380 +8613230482270 | 1919301810@qq.com | China | 141 | 58 |
| Xinxiang Juyuan Biological Technology Co., Ltd. | +8615637360870 | sales@xxkfqchem.com | China | 19 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
Related articles
- Fmoc-Chloride: A Cornerstone Reagent in Peptide Synthesis and Organic Chemistry
- Fmoc-Chloride is a widely utilized chemical reagent in the field of organic chemistry, particularly in peptide synthesis.
- Aug 28，2024
Related Qustion
Ask a questionView Lastest Price from 9-Fluorenylmethyl chloroformate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-21 | FMOC-CL
28920-43-6
|
$750.00 | 1kg | 99 | 50tons | Xinxiang Juyuan Biological Technology Co., Ltd. | |
 |
2026-07-09 | 9-Fluorenylmethyl chloroformate
28920-43-6
|
$1.00-8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 9-Fluorenylmethyl chloroformate
28920-43-6
|
1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- FMOC-CL
28920-43-6
- $750.00
- 99
- Xinxiang Juyuan Biological Technology Co., Ltd.
-
- 9-Fluorenylmethyl chloroformate
28920-43-6
- $1.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 9-Fluorenylmethyl chloroformate
28920-43-6
- 98
- Shaanxi Dideu New Materials Co. Ltd
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