OPC-14523
- CAS No.
- 145969-30-8
- Chemical Name:
- OPC-14523
- Synonyms
- VPI013;VPI 013;VPI-013;OPC-14523;OPC-14523 free base;OPC 14523 free base,OPC14523 free base;1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-methoxy-3,4-dihydro-2-quinolinone;2(1H)-Quinolinone, 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4-dihydro-5-methoxy-
- CBNumber:
- CB72446504
- Molecular Formula:
- C23H28ClN3O2
- Molecular Weight:
- 413.94
- MDL Number:
- MFCD00915596
- MOL File:
- 145969-30-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| OPC-14523 95.00% | API0009234 | 5MG | $504.37 |
| FDA UNII | 1981OTB4DS |
|---|
OPC-14523 Chemical Properties,Uses,Production
Uses
OPC-14523 free base is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 free base shows antidepressant-like activity[1][2].
in vivo
OPC-14523 free base (0.3-100 mg/kg; p.o.; daily for 0, 2, 4, 7 days) produces a marked antidepressant-like effect in the forced swimming test (FST) with rats and mice without affecting the general locomotor activity[1].
| Animal Model: | Wistar strain of rats (140-245 g)[1] |
| Dosage: | 0.3-100 mg/kg |
| Administration: | P.o.; daily for 0, 2, 4, 7 days |
| Result: | A single doses of 1 mg/kg and higher of OPC-14523 reduced immobility time in the FST with an ED50 value of 27 mg/kg. The ED50 value for OPC-14523 on day 7 was 18 mg/kg. |
| Animal Model: | ICR strain of mice (25-45 g)[1] |
| Dosage: | 0.3-100 mg/kg |
| Administration: | P.o.; daily for 0, 2, 4, 7 days |
| Result: | A single oral dose of OPC-14523 produced a marked reduction in immobility time during the FST at oral doses of 1 mg/kg and higher, with an ED50 value of 20 mg/kg. The potency of OPC-14523 in decreasing immobility time was greater after treatment for seven consecutive days, producing an ED50 value of 2 mg/kg. |
IC 50
sigma 1: 47 nM (IC50); sigma 2: 56 nM (IC50); 5-HT1A Receptor: 2.3 nM (IC50)
References
[1] Tottori K, et al. Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001;41(8):976-988. DOI:10.1016/s0028-3908(01)00147-2
[2] Bermack JE, et al. Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsa DOI:10.1124/jpet.104.066472
OPC-14523 Preparation Products And Raw materials
OPC-14523 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2028 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20033 | 58 |
View Lastest Price from OPC-14523 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | OPC-14523 free base
145969-30-8
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
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- OPC-14523 free base
145969-30-8
- $1520.00-2500.00
- TargetMol Chemicals Inc.
