GSK J1
- CAS No.
- 1373422-53-7
- Chemical Name:
- GSK J1
- Synonyms
- GSK-J1;GSK J1;GCK J1;CS-2305;GSK J1 ，S7581;GSK-J1, 10 mM in DMSO;Histone demethylase inhibitor J1;GSK-J1, H3K27 histone demethylase inhibitor;Histone Lysine Demethylase Inhibitor VII, GSK-J1;Histone Lysine Demethylase Inhibitor VII, GSK-J1 - CAS 1373422-53-7 - Calbiochem
- CBNumber:
- CB72668658
- Molecular Formula:
- C22H23N5O2
- Molecular Weight:
- 389.45
- MDL Number:
- MFCD22683851
- MOL File:
- 1373422-53-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| GSK-J1 ≥98% (HPLC) | SML0709 | 5mg | $122 |
| Histone Lysine Demethylase Inhibitor VII, GSK-J1 | 420204-M | 10 mg | $171 |
| Histone Lysine Demethylase Inhibitor VII, GSK-J1 | 420204-M | 1 unit | $160 |
| Histone Lysine Demethylase Inhibitor VII, GSK-J1 (3-(6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoic Acid, JHDM Inhibitor II) ≥98%(HPLC) | 217430 | 10mg | $588 |
| GSK-J1 | YEC42253 | 50mg | $871 |
| More product size | |||
| Boiling point | 608.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| pka | 4.20±0.10(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | 1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26) |
| InChIKey | AVZCPICCWKMZDT-UHFFFAOYSA-N |
| SMILES | OC(CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CC=N4)=N1)=O |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
GSK J1 price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0709 | GSK-J1 ≥98% (HPLC) | 1373422-53-7 | 5mg | $122 | 2026-04-30 | Buy |
| Sigma-Aldrich | 420204-M | Histone Lysine Demethylase Inhibitor VII, GSK-J1 | 1373422-53-7 | 10 mg | $171 | 2026-04-30 | Buy |
| Sigma-Aldrich | 420204-M | Histone Lysine Demethylase Inhibitor VII, GSK-J1 | 1373422-53-7 | 1 unit | $160 | 2025-07-31 | Buy |
| Usbiological | 217430 | Histone Lysine Demethylase Inhibitor VII, GSK-J1 (3-(6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoic Acid, JHDM Inhibitor II) ≥98%(HPLC) | 1373422-53-7 | 10mg | $588 | 2026-06-03 | Buy |
| Biosynth | YEC42253 | GSK-J1 | 1373422-53-7 | 50mg | $871 | 2026-06-05 | Buy |
GSK J1 Chemical Properties,Uses,Production
Description
GSK-J1 (1373422-53-7) is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such GSK-J1 is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available, see GSK-J4 (cat.# 10-1394).
Uses
GSK J1 is a selective and potent inhibitor of JMJDE and UTX demethylases.
Definition
ChEBI: 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid is an organonitrogen heterocyclic compound.
Biochem/physiol Actions
GSK-J1 is also termed as 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate. It may disturb the differentiation of specific neuronal subtypes in growing rat retina.
storage
room temperature (desiccate)
References
[1] LAURENS KRUIDENIER. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response[J]. Nature, 2012, 488 7411: 404-408. DOI:10.1038/nature11262
GSK J1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
View Lastest Price from GSK J1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-26 | GSK-J1
1373422-53-7
|
$40.00-98.00 | 99.67% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-12 | GSK J1
1373422-53-7
|
1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
 |
2020-01-13 | GSK-J1
1373422-53-7
|
$1.00 | 1g | 99% | 1ton | Career Henan Chemical Co |
