5-Fluoro-3-indazolecarboxylic acid
- CAS No.
- 1077-96-9
- Chemical Name:
- 5-Fluoro-3-indazolecarboxylic acid
- Synonyms
- 5-FLUORO-1H-INDAZOLE-3-CARBOXYLIC ACID;5-FLUORO-3-INDAZOLECARBOXYLIC ACID;5-FLUORO-INDAZOLE-3-CARBOXYLIC ACID;5-FLUORO-INDOZOLE-3-CARBOXYLIC ACID;5-fluoro-1H-indazol-3-carboxylic acid;5-Fuoro-1H-indazole-3-carboxylic acid;5-Fuloro-1H-indazole-3-carboxylic acid;1H-Indazole-3-carboxylic acid, 5-fluoro-;5-Fluoro-1H-indazole-3-carboxylic acid 95%;5-fluoro-1H-indazole-3-carboxylic acid - [F16425]
- CBNumber:
- CB7285718
- Molecular Formula:
- C8H5FN2O2
- Molecular Weight:
- 180.14
- MDL Number:
- MFCD03840628
- MOL File:
- 1077-96-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Fluoro-1H-indazole-3-carboxylic acid 98% | PC448014 | 250mg | $21 |
| 5-Fluoro-1H-indazole-3-carboxylic acid 98% | PC448014 | 1g | $45 |
| 5-Fluoro-1H-indazole-3-carboxylic acid 98% | PC448014 | 5g | $177 |
| 5-Fluoro-1H-indazole-3-carboxylic acid 98% | PC448014 | 25g | $848 |
| 5-Fluoro-1H-indazole-3-carboxylic acid 98% | PC448014 | 250mg | $21 |
| More product size | |||
| Melting point | 299 °C |
|---|---|
| Boiling point | 445.9±25.0 °C(Predicted) |
| Density | 1.610±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 2.89±0.30(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C8H5FN2O2/c9-4-1-2-6-5(3-4)7(8(12)13)11-10-6/h1-3H,(H,10,11)(H,12,13) |
| InChIKey | XFHIMKNXBUKQNS-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(F)C=C2)C(C(O)=O)=N1 |
| CAS DataBase Reference | 1077-96-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2917399590 |
5-Fluoro-3-indazolecarboxylic acid price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC448014 | 5-Fluoro-1H-indazole-3-carboxylic acid 98% | 1077-96-9 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC448014 | 5-Fluoro-1H-indazole-3-carboxylic acid 98% | 1077-96-9 | 1g | $45 | 2026-06-04 | Buy |
| Apolloscientific | PC448014 | 5-Fluoro-1H-indazole-3-carboxylic acid 98% | 1077-96-9 | 5g | $177 | 2026-06-04 | Buy |
| Apolloscientific | PC448014 | 5-Fluoro-1H-indazole-3-carboxylic acid 98% | 1077-96-9 | 25g | $848 | 2026-06-04 | Buy |
| Apolloscientific | PC448014 | 5-Fluoro-1H-indazole-3-carboxylic acid 98% | 1077-96-9 | 250mg | $21 | 2026-06-04 | Buy |
5-Fluoro-3-indazolecarboxylic acid Chemical Properties,Uses,Production
Uses
5-Fluoroinazole-3-carboxylic acid is a pharmaceutical intermediate.
Chemical Properties
yellow powder
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 1, p. 239, 1964 DOI: 10.1002/jhet.5570010505
Synthesis
443-69-6
1077-96-9
The general procedure for the synthesis of 5-fluoroindazole-3-carboxylic acid from 5-fluoroindigo is as follows: first, sodium hydroxide (1.24 g, 0.031 mol, 1.03 eq.) was dissolved in water (19 mL) and heated to 50 °C, then 5-fluoroindigo (5 g, 0.03 mol, 1 eq.) was added. 5 minutes later, the resulting deep red solution was cooled to 0 °C, followed by the slow addition of a pre-cooled sodium nitrite (2.07 g, 0.03 mol, 1 eq.) solution in water (10 mL). Immediately thereafter, the cooled 95% sulfuric acid (3.12 mL, 0.06 mol, 1.95 eq.) water (48 mL) solution was added rapidly, controlling the rate of addition to ensure that the temperature did not exceed 4°C. A small amount of ether may be added at the appropriate time to minimize foaming during mixing. After the addition was complete, stirring was continued at less than 4°C for 1 hour. Subsequently, a 35% hydrochloric acid (24 mL) solution of pre-cooled stannous chloride (16.24 g, 0.072 mol, 2.4 eq.) was added and the mixture was stirred for 16 hours. After completion of the reaction, the brown solution was filtered and the resulting brown solid was washed with water to give a final light brown solid product (2.73 g, 51% yield). The NMR hydrogen spectral (MeOH-d4) data of the product were as follows: δH 7.25 (1H, td, J = 9.10 Hz and 2.14 Hz, ArH), 7.60 (1H, dd, J = 9.10 Hz and 4.28 Hz, ArH), 7.74 (1H, dd, J = 9.10 Hz and 2.10 Hz, ArH); LC-MS-EI showed the molecular ion peak m/z 183.1 (MH+, 100).
References
[1] Patent: WO2011/61469, 2011, A1. Location in patent: Page/Page column 34-35
[2] Patent: US2005/250808, 2005, A1. Location in patent: Page/Page column 39
[3] Patent: US2006/142247, 2006, A1. Location in patent: Page/Page column 39
[4] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0349
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 15, p. 6259 - 6272
5-Fluoro-3-indazolecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-17392712779 | 1097@dideu.com | China | 3992 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
View Lastest Price from 5-Fluoro-3-indazolecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | 5-Fluoro-3-indazolecarboxylic acid
1077-96-9
|
1KG | 98.0% | 10 | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | 5-Fluoro-3-indazolecarboxylic acid
1077-96-9
|
$1.00 | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- 5-Fluoro-3-indazolecarboxylic acid
1077-96-9
- $0.10
- 98.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Fluoro-3-indazolecarboxylic acid
1077-96-9
- $1.00
- 98%
- Career Henan Chemical Co
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