1-Methyl-1H-pyrazole-5-carbaldehyde
- CAS No.
- 27258-33-9
- Chemical Name:
- 1-Methyl-1H-pyrazole-5-carbaldehyde
- Synonyms
- 5-FORMYL-1-METHYL-1H-PYRAZOLE;AKOS B007393;ART-CHEM-BB B007393;ASINEX-REAG BAS 10156687;5-Formyl-1-methylpyrazole;1-Methylpyrazole-5-carbaldehyde;2-methylpyrazole-3-carbaldehyde;1-Methylpyrazole-5-carboxaldehyde;2-methyl-3-pyrazolecarboxaldehyde;2-Methyl-2H-Pyrazole-2carbaldehyde
- CBNumber:
- CB7339033
- Molecular Formula:
- C5H6N2O
- Molecular Weight:
- 110.11
- MDL Number:
- MFCD03419801
- MOL File:
- 27258-33-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Methylpyrazole-5-carboxaldehyde >95.0%(GC) | M2179 | 1g | $64 |
| 1-Methyl-1H-pyrazole-5-carbaldehyde Asreported | 283083 | 10g | $1007 |
| 1-Methyl-1H-pyrazole-5-carbaldehyde Asreported | 283083 | 25g | $1459 |
| 1-Methyl-1H-pyrazole-5-carbaldehyde Asreported | 283083 | 50g | $2099 |
| 1-Methyl-1H-pyrazole-5-carbaldehyde Asreported | 283083 | 100g | $2987 |
| More product size | |||
| Boiling point | 115/15mm |
|---|---|
| Density | 1.118 g/mL at 25 °C |
| refractive index | n20/D1.521 |
| Flash point | 66℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | clear liquid |
| pka | 0.56±0.10(Predicted) |
| color | Colorless to Light orange to Yellow |
| CAS DataBase Reference | 27258-33-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H317-H319-H335-H227 | |||||||||
| Precautionary statements | P210-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501-P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29331990 | |||||||||
| NFPA 704 |
|
1-Methyl-1H-pyrazole-5-carbaldehyde price More Price(84)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2179 | 1-Methylpyrazole-5-carboxaldehyde >95.0%(GC) | 27258-33-9 | 1g | $64 | 2026-04-30 | Buy |
| Usbiological | 283083 | 1-Methyl-1H-pyrazole-5-carbaldehyde Asreported | 27258-33-9 | 10g | $1007 | 2026-06-03 | Buy |
| Usbiological | 283083 | 1-Methyl-1H-pyrazole-5-carbaldehyde Asreported | 27258-33-9 | 25g | $1459 | 2026-06-03 | Buy |
| Usbiological | 283083 | 1-Methyl-1H-pyrazole-5-carbaldehyde Asreported | 27258-33-9 | 50g | $2099 | 2026-06-03 | Buy |
| Usbiological | 283083 | 1-Methyl-1H-pyrazole-5-carbaldehyde Asreported | 27258-33-9 | 100g | $2987 | 2026-06-03 | Buy |
1-Methyl-1H-pyrazole-5-carbaldehyde Chemical Properties,Uses,Production
Uses
1-methyl-1H-pyrazole-5-carbaldehyde is a pyrazole derivative used in the synthesis of 1-methylpyrazole aldehyde and 1-methyl-2-pyrazoline aldehyde and their acetals.
Synthesis
930-36-9
68-12-2
27258-33-9
Example 1. Synthesis of 1-methyl-1H-pyrazole-5-carbaldehyde To a dry 50 mL reaction flask was added 1.642 g (20 mmol) of 1-methylpyrazole dissolved in 30 mL of anhydrous THF. The reaction mixture was cooled to -20 °C and 8 mL (20 mmol, 2.5 M hexane solution) of n-butyllithium solution was added slowly with stirring. The reaction was kept at -20 °C with stirring for 2.5 hours. Subsequently, 4.7 mL (4.39 g, 60 mmol) of anhydrous N,N-dimethylformamide was slowly added at -20 °C under vigorous stirring and the reaction was continued at this temperature for 1 hour. Upon completion of the reaction, the mixture was poured into 100 mL of 1 M acetic acid/sodium acetate buffer (pH 4.5) and 50 mL of methyl tert-butyl ether (MTBE) was added to separate the organic layer. The organic layer was washed with 50 mL of saturated sodium carbonate solution to remove excess acetic acid (note: extraction with ethyl acetate may result in residual N,N-dimethylformamide in the final product). The organic layer was separated, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by vacuum distillation (boiling point: 67 °C, 21 mbar). The products of the three preparations were combined and distilled to give 5.969 g (54 mmol, 90% yield) of 1-methyl-1H-pyrazole-5-carbaldehyde. 1H NMR (300 MHz, CDCl3): δ 4.18 (s, 3H, CH3-N), 6.91 (d, 1H, 3J = 2.0 Hz, CH=CN), 7.53 (d, 1H, 3J = 2.0 Hz, CH=N), 9.87 (s, 1H, CHO) ppm. 13C NMR (100 MHz, CDCl3): δ 39.31 (CH3-N), 114.78 (CH=C-N), 138.54 (CH=N), 138.98 (CH=C-N), 179.83 (CHO) ppm.
References
[1] Patent: EP1671953, 2006, A1. Location in patent: Page/Page column 9
[2] Patent: EP1671968, 2006, A1. Location in patent: Page/Page column 10
[3] Patent: EP1982987, 2008, A1. Location in patent: Page/Page column 15; 45
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6704 - 6713
[5] Patent: EP1186604, 2002, A1. Location in patent: Page 107
1-Methyl-1H-pyrazole-5-carbaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from 1-Methyl-1H-pyrazole-5-carbaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 1-Methyl-1H-pyrazole-5-carbaldehyde
27258-33-9
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-24 | 1-Methyl-1H-pyrazole-5-carbaldehyde
27258-33-9
|
$865.00 | 1KG | 98% | 1T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 1-Methyl-1H-pyrazole-5-carbaldehyde
27258-33-9
|
$500.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- 1-Methyl-1H-pyrazole-5-carbaldehyde
27258-33-9
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 1-Methyl-1H-pyrazole-5-carbaldehyde
27258-33-9
- $865.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 1-Methyl-1H-pyrazole-5-carbaldehyde
27258-33-9
- $500.00
- 98%
- Career Henan Chemical Co
