Ethylmethyl-carbamic chloride
- CAS No.
- 42252-34-6
- Chemical Name:
- Ethylmethyl-carbamic chloride
- Synonyms
- n-ethyl-n-methylcarbamoyl chloride;ETHYLMETHYLCARBAMOYL CHLORIDE;Bosutinib Impurity 42;Rivastigmine Intermediate 1;Ethylmethy-Carbamic Chloride;Ethylmethyl-carbamic chloride;CARBAMIC CHLORIDE, ETHYLMETHYL-;N-ethyl-N-methyl caroylchloride;N-Ethyl-N-methylcarbamic chloride;N-ethyl-n-methylcarbamyl chloride
- CBNumber:
- CB7352742
- Molecular Formula:
- C4H8ClNO
- Molecular Weight:
- 121.57
- MDL Number:
- MFCD08061404
- MOL File:
- 42252-34-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-Ethyl-N-methylcarbamoyl Chloride >98.0%(GC)(T) | E0963 | 25g | $108 |
| N-Ethyl-N-methylcarbamoyl chloride Asreported | 275352 | 5g | $359 |
| N-Ethyl-N-methylcarbamoyl chloride Asreported | 275352 | 10g | $468 |
| N-Ethyl-N-methylcarbamoyl chloride Asreported | 275352 | 25g | $649 |
| N-Ethyl-N-methylcarbamoyl chloride Asreported | 275352 | 50g | $832 |
| More product size | |||
| Boiling point | 89°C/40mmHg(lit.) |
|---|---|
| Density | 1.101±0.06 g/cm3(Predicted) |
| refractive index | 1.4500-1.4540 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) |
| form | clear liquid |
| pka | -1.85±0.70(Predicted) |
| color | Colorless to Almost colorless |
| Stability | Hygroscopic |
| InChI | InChI=1S/C4H8ClNO/c1-3-6(2)4(5)7/h3H2,1-2H3 |
| InChIKey | XZVYDRLPXWFRIS-UHFFFAOYSA-N |
| SMILES | C(Cl)(=O)N(CC)C |
| CAS DataBase Reference | 42252-34-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H290-H314 |
| Precautionary statements | P234-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501 |
| RIDADR | 3265 |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 2924190015 |
| REACH Registrations | Active |
Ethylmethyl-carbamic chloride price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0963 | N-Ethyl-N-methylcarbamoyl Chloride >98.0%(GC)(T) | 42252-34-6 | 25g | $108 | 2026-04-30 | Buy |
| Usbiological | 275352 | N-Ethyl-N-methylcarbamoyl chloride Asreported | 42252-34-6 | 5g | $359 | 2026-06-03 | Buy |
| Usbiological | 275352 | N-Ethyl-N-methylcarbamoyl chloride Asreported | 42252-34-6 | 10g | $468 | 2026-06-03 | Buy |
| Usbiological | 275352 | N-Ethyl-N-methylcarbamoyl chloride Asreported | 42252-34-6 | 25g | $649 | 2026-06-03 | Buy |
| Usbiological | 275352 | N-Ethyl-N-methylcarbamoyl chloride Asreported | 42252-34-6 | 50g | $832 | 2026-06-03 | Buy |
Ethylmethyl-carbamic chloride Chemical Properties,Uses,Production
Uses
N-Ethyl-N-methylcarbamoyl chloride is used as an intermediate for rivastigmine.
Application
N-Ethyl-N-methylcarbamoyl chloride is a compound that can be used in organic synthesis.
Chemical Properties
Pale Yellow Oil
Synthesis
624-78-2
32315-10-9
42252-34-6
Example 1: A solution of N-ethylmethylamine (100 g, 1.69 mol) in dichloromethane (1.5 L) was slowly added dropwise to a suspension in dichloromethane (2 L) containing sodium bicarbonate (284 g, 3.384 mol) and triphosgene (332 g, 1.117 mol), the temperature was maintained at a controlled level of 10-15°C, and the dropwise process lasted for 2 hours. After completion of the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 3 hours. Upon completion of the reaction, the resulting sodium chloride was removed by filtration and the filtrate was concentrated under reduced pressure to afford 189 g of N-methyl-N-ethylcarbamoyl chloride, the product being a light yellow oil (yield: 92%). Example 3: The procedure of Example 2 was repeated, only the solvent was changed to methylene chloride, and the rest of the reaction conditions remained unchanged. The experimental results are shown in Table 2, the yield consistently exceeded 98%.
References
[1] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 12; 13
[2] Research on Chemical Intermediates, 2014, vol. 40, # 2, p. 787 - 800
[3] Patent: WO2013/150529, 2013, A2. Location in patent: Page/Page column 24; 25; 28; 29
[4] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 13
Ethylmethyl-carbamic chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
View Lastest Price from Ethylmethyl-carbamic chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | Ethylmethyl-carbamic chloride
42252-34-6
|
$10.00 | 1KG | 99.% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | Ethylmethyl-carbamic chloride
42252-34-6
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-01-04 | N,N-ETHYLMETHYL CARBAMOYL CHLORIDE
42252-34-6
|
99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd |
-
- Ethylmethyl-carbamic chloride
42252-34-6
- $10.00
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Ethylmethyl-carbamic chloride
42252-34-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- N,N-ETHYLMETHYL CARBAMOYL CHLORIDE
42252-34-6
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
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