EMBELIN
- CAS No.
- 550-24-3
- Chemical Name:
- EMBELIN
- Synonyms
- EMBELIN;emberine;NSC 91874;Embelin-RM;embelicacid;Embelin, >98%;XIAP INHIBITOR;EMbeliaquinone;Embelin (Standard);TIMTEC-BB SBB005949
- CBNumber:
- CB7365074
- Molecular Formula:
- C17H26O4
- Molecular Weight:
- 294.39
- MDL Number:
- MFCD00016369
- MOL File:
- 550-24-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Embelin ≥98% (HPLC), powder | E1406 | 10mg | $127 |
| Apoptosis Activator III, Embelin | 178493 | 10mg | $162 |
| Embelin | E1547 | 100MG | $232 |
| Embelin ≥95% | 11838 | 10mg | $75 |
| Embelin ≥95% | 11838 | 50mg | $333 |
| More product size | |||
| Melting point | 142-143°C |
|---|---|
| Boiling point | 356.15°C (rough estimate) |
| Density | 1.131 |
| refractive index | 1.4230 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: >10 mg/mL |
| form | solid |
| pka | 2.84±0.50(Predicted) |
| color | Dark orange |
| Sensitive | Light Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChI | 1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3 |
| InChIKey | IRSFLDGTOHBADP-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O |
| LogP | 5.024 (est) |
| FDA UNII | SHC6U8F5ER |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361f |
| Precautionary statements | P201-P308+P313 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| RTECS | DK4230000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Repr. 2 |
EMBELIN price More Price(107)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E1406 | Embelin ≥98% (HPLC), powder | 550-24-3 | 10mg | $127 | 2026-04-30 | Buy |
| Sigma-Aldrich | 178493 | Apoptosis Activator III, Embelin | 550-24-3 | 10mg | $162 | 2026-04-30 | Buy |
| TCI Chemical | E1547 | Embelin | 550-24-3 | 100MG | $232 | 2026-04-30 | Buy |
| Cayman Chemical | 11838 | Embelin ≥95% | 550-24-3 | 10mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 11838 | Embelin ≥95% | 550-24-3 | 50mg | $333 | 2026-04-30 | Buy |
EMBELIN Chemical Properties,Uses,Production
Description
Embelin (550-24-3) inhibitsthe lysine acetyl transferase PCAFin vitro and in vivo(in vitroIC50=7.2 mM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged.1 Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells.3Possesses anti-inflammatory and analgesic activityin vivo.4Cell-permeable.
Chemical Properties
Orange Solid
Uses
Embelin is a natural benzoquinone found in plants of the Myrsinaceae family. Embelin has a wide range of biological activity as it inhibits the growth of bacteria, fungi, protozoa and parasites. Embelin also displays contraceptive and pro-apoptotic properties.
Definition
ChEBI: A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, an ineoplastic and inhibitory activity towards hepatitis C protease.
Biological Activity
Cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC 50 = 4.1 μ M in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC 50 4-6 μ M), but has a weaker effect on normal prostate cells (IC 50 = 19-20 μ M). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo .
References
[1] RAHUL MODAK. Probing p300/CBP Associated Factor (PCAF)-Dependent Pathways with a Small Molecule Inhibitor[J]. ACS Chemical Biology, 2013, 8 6: 1311-1323. DOI:10.1021/cb4000597
[2] ZANETA NIKOLOVSKA-COLESKA. Discovery of Embelin as a Cell-Permeable, Small-Molecular Weight Inhibitor of XIAP through Structure-Based Computational Screening of a Traditional Herbal Medicine Three-Dimensional Structure Database[J]. Journal of Medicinal Chemistry, 2004, 47 10: 2430-2440. DOI:10.1021/jm030420+
[3] PRIYANK SHAH. Embelin inhibits proliferation, induces apoptosis and alters gene expression profiles in breast cancer cells[J]. Pharmacological Reports, 2016, 68 3: Pages 638-644. DOI:10.1016/j.pharep.2016.01.004
[4] M CHITRA. Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.[J]. Chemotherapy, 1994, 40 2: 109-113. DOI:10.1159/000239181
EMBELIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 4616 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3991 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
View Lastest Price from EMBELIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-11 | Pinoresinol diglucoside
550-24-3
|
1g | 98% | 2000 | Changsha Staherb Natural Ingredients Co., Ltd. | ||
 |
2026-05-11 | Embelin
550-24-3
|
$48.00-152.00 | 99.95% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Embelin
550-24-3
|
20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Pinoresinol diglucoside
550-24-3
- 98%
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Embelin
550-24-3
- $48.00-152.00
- 99.95%
- TargetMol Chemicals Inc.
-
- Embelin
550-24-3
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
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