MMP-9/MMP-13 INHIBITOR I
- CAS No.
- 204140-01-2
- Chemical Name:
- MMP-9/MMP-13 INHIBITOR I
- Synonyms
- MMP-9/MMP-13 INHIBITOR I;MMP-9/MMP-13 INHIBITOR II;MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem[444252];N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYLPIPERAZINE-2-CARBOXAMIDE;N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-(4-BIPHENYLCARBONYL)PIPERAZINE-2-CARBOXAMIDE;2-Piperazinecarboxamide, 4-([1,1'-biphenyl]-4-ylcarbonyl)-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-
- CBNumber:
- CB7427176
- Molecular Formula:
- C25H25N3O6S
- Molecular Weight:
- 495.55
- MDL Number:
- MFCD03453559
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem | 444252 | 1MG | $149 |
| MMP-9/MMP-13 Inhibitor I ≥98% | 21265 | 500μg | $81 |
| MMP-9/MMP-13 Inhibitor I ≥98% | 21265 | 1mg | $143 |
| MMP-9/MMP-13 Inhibitor I ≥98% | 21265 | 500μg | $73 |
| MMP-9/MMP-13 Inhibitor I ≥98% | 21265 | 1mg | $130 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| WGK Germany | WGK 1 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
MMP-9/MMP-13 INHIBITOR I price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 444252 | MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem | 204140-01-2 | 1MG | $149 | 2026-04-30 | Buy |
| Cayman Chemical | 21265 | MMP-9/MMP-13 Inhibitor I ≥98% | 204140-01-2 | 500μg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 21265 | MMP-9/MMP-13 Inhibitor I ≥98% | 204140-01-2 | 1mg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 21265 | MMP-9/MMP-13 Inhibitor I ≥98% | 204140-01-2 | 500μg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 21265 | MMP-9/MMP-13 Inhibitor I ≥98% | 204140-01-2 | 1mg | $130 | 2024-03-01 | Buy |
MMP-9/MMP-13 INHIBITOR I Chemical Properties,Uses,Production
Description
MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.
Uses
A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13
IC 50
MMP-9: 0.9 nM (IC50); MMP-13: 0.9 nM (IC50); MMP-1: 43 nM (IC50); MMP-3: 23 nM (IC50); MMP-7: 931 nM (IC50)
References
[1] MENYAN CHENG. Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors[J]. Journal of Medicinal Chemistry, 2000, 43 3: 369-380. DOI: 10.1021/jm990366q
[2] MAURO PRATO. Phagocytosis of hemozoin enhances matrix metalloproteinase-9 activity and TNF-alpha production in human monocytes: role of matrix metalloproteinases in the pathogenesis of falciparum malaria.[J]. Journal of immunology, 2005, 175 10: 6436-6442. DOI: 10.4049/jimmunol.175.10.6436
[3] PETER STORZ. FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.[J]. Molecular and Cellular Biology, 2009, 29 18: 4906-4917. DOI: 10.1128/mcb.00077-09
[4] MUTHULEKHA SWAMYDAS. Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases.[J]. Cell Adhesion & Migration, 2013, 7 3: 315-324. DOI: 10.4161/cam.25138
MMP-9/MMP-13 INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Alabiotech Inc. | 001-619-354-5251 | sales@alabiotech-e.com | United States | 972 | 60 |
| Alpha Biopharmaceuticals Co., Ltd | 0411-39042497 | sales@alphabiopharm.com | China | 1951 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Easy CDMO Co.,Ltd | 13564957716 | Info@easycdmo.com | China | 10000 | 58 |
