2,5-DIFLUOROBENZENESULFONYL CHLORIDE
- CAS No.
- 26120-86-5
- Chemical Name:
- 2,5-DIFLUOROBENZENESULFONYL CHLORIDE
- Synonyms
- 2,3-Difluorobenzenesulfonyl chloride;AKOS B019395;BUTTPARK 21\07-13;ART-CHEM-BB B019395;2,5-DIAMIONPYRIMIDINE;2,5-Difluorobenzenesulphonylchlori;2,5-DIFLUOROBENZENESULFONYL CHLORIDE;2,5-DIFLUOROBENZENESULPHONYL CHLORIDE;2,5-Difluorobenzenesulphonylchloride98%;2,5-difluorobenzene-1-sulfonyl chloride
- CBNumber:
- CB7456219
- Molecular Formula:
- C6H3ClF2O2S
- Molecular Weight:
- 212.6
- MDL Number:
- MFCD00060682
- MOL File:
- 26120-86-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,5-Difluorobenzenesulfonyl chloride 97% | 555428 | 5g | $50.8 |
| 2,5-Difluorobenzenesulfonyl chloride 97% | 555428 | 1g | $24 |
| 2,5-Difluorobenzenesulphonyl chloride 98% | PC3754 | 5g | $21 |
| 2,5-Difluorobenzenesulphonyl chloride 98% | PC3754 | 25g | $24 |
| 2,5-Difluorobenzenesulphonyl chloride 98% | PC3754 | 100g | $41 |
| More product size | |||
| Boiling point | 221 °C (lit.) |
|---|---|
| Density | 1.58 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | liquid |
| color | Clear, yellow/green |
| Sensitive | Moisture Sensitive |
| BRN | 2723886 |
| InChI | 1S/C6H3ClF2O2S/c7-12(10,11)6-3-4(8)1-2-5(6)9/h1-3H |
| InChIKey | CELLJWUVMKEJDY-UHFFFAOYSA-N |
| SMILES | Fc1ccc(F)c(c1)S(Cl)(=O)=O |
| CAS DataBase Reference | 26120-86-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
|||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
2,5-DIFLUOROBENZENESULFONYL CHLORIDE price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 555428 | 2,5-Difluorobenzenesulfonyl chloride 97% | 26120-86-5 | 5g | $50.8 | 2023-06-20 | Buy |
| Sigma-Aldrich | 555428 | 2,5-Difluorobenzenesulfonyl chloride 97% | 26120-86-5 | 1g | $24 | 2023-01-07 | Buy |
| Apolloscientific | PC3754 | 2,5-Difluorobenzenesulphonyl chloride 98% | 26120-86-5 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC3754 | 2,5-Difluorobenzenesulphonyl chloride 98% | 26120-86-5 | 25g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC3754 | 2,5-Difluorobenzenesulphonyl chloride 98% | 26120-86-5 | 100g | $41 | 2026-06-04 | Buy |
2,5-DIFLUOROBENZENESULFONYL CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
Clear colorless to yellow liquid
Uses
2,5-Difluorobenzenesulfonyl chloride participates in the synthesis of aryl sulfonamide-based mineralocorticoid receptor (MR) antagonists.
General Description
2,5-Difluorobenzenesulfonyl chloride participates in the synthesis of aryl sulfonamide-based mineralocorticoid receptor (MR) antagonists.
Synthesis
367-30-6
26120-86-5
The general procedure for the synthesis of 2,5-difluorobenzenesulfonyl chloride from 2,5-difluoroaniline was as follows: 12.9 g (99.9 mmol) of 2,5-difluoroaniline was rapidly added to a mixture prepared from 33 mL of concentrated hydrochloric acid and 10 mL of acetic acid in ethanol cooled to just below -10°C. The solution of 2,5-difluorobenzenesulfonyl chloride in ethanol was then added dropwise. Subsequently, a solution of 7.4 g (107 mmol) of sodium nitrite dissolved in 15 mL of water was added dropwise. After the dropwise addition, stirring was continued for 45 minutes at a temperature range of -10 to -25°C. Maintaining the temperature of the reaction solution at about -25 °C, a mixture consisting of 100 mL of acetic acid saturated with sulfur dioxide and 2.5 g (25.3 mmol) cuprous chloride was added in batches, a process that required cooling to 10 °C in an ice bath. A large amount of nitrogen generation was observed during the reaction. The reaction mixture was brought back to room temperature and kept for 2 h. Subsequently, it was poured into 450 mL of ice-water mixture and extracted with ether. The ether extracts were combined, washed with saturated aqueous sodium bicarbonate, dried over sodium sulfate and concentrated. The resulting oily residue was distilled under reduced pressure to give 14.3 g (87% yield) of a liquid product consisting mainly of 2,5-difluorobenzenesulfonyl chloride with a boiling point of 65-70 °C (0.5 mmHg), which could be used in subsequent steps without further purification.
References
[1] Patent: US6509499, 2003, B1
[2] Journal of Chemical Information and Modeling, 2015, vol. 54, # 12, p. 3404 - 3416
2,5-DIFLUOROBENZENESULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1444 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2163 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10817 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9631 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
View Lastest Price from 2,5-DIFLUOROBENZENESULFONYL CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-08-06 | 2,5-DIFLUOROBENZENESULFONYL CHLORIDE
26120-86-5
|
$1.00 | 1KG | 95-99% | 100kg/week | Career Henan Chemical Co |
-
- 2,5-DIFLUOROBENZENESULFONYL CHLORIDE
26120-86-5
- $1.00
- 95-99%
- Career Henan Chemical Co
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