TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98
- CAS No.
- 845306-08-3
- Chemical Name:
- TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98
- Synonyms
- tert-butyl 5-bromopicolinate;5-Bromopicolinic acid tert-butyl ester;TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98;tert-Butyl 5-bromopyridine-2-carboxylate 98%;5-Bromopyridine-2-carboxylic acid t-butyl ester;2-Methyl-2-propanyl 5-bromo-2-pyridinecarboxylate;5-Bromo-pyridine-2-carboxylic acid tert-butyl ester;5-Bromo-2-pyridinecarboxylic acid 1,1-dimethylethyl ester;2-Pyridinecarboxylic acid, 5-broMo-, 1,1-diMethylethyl ester;TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 ISO 9001：2015 REACH
- CBNumber:
- CB7501304
- Molecular Formula:
- C10H12BrNO2
- Molecular Weight:
- 258.11
- MDL Number:
- MFCD08436052
- MOL File:
- 845306-08-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| tert-Butyl 5-bromopyridine-2-carboxylate | VIB30608 | 10g | $354 |
| tert-Butyl 5-bromopyridine-2-carboxylate 97% | OR3355 | 250mg | $21 |
| tert-Butyl 5-bromopyridine-2-carboxylate 97% | OR3355 | 1g | $32 |
| tert-Butyl 5-bromopyridine-2-carboxylate 97% | OR3355 | 5g | $154 |
| tert-Butyl 5-bromopyridine-2-carboxylate 97% | OR3355 | 25g | $693 |
| Melting point | 92-94 |
|---|---|
| Boiling point | 318℃ |
| Density | 1.385 |
| Flash point | 146℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | -0.52±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C10H12BrNO2/c1-10(2,3)14-9(13)8-5-4-7(11)6-12-8/h4-6H,1-3H3 |
| InChIKey | GBAJDPJECJPPSP-UHFFFAOYSA-N |
| SMILES | C1(C(OC(C)(C)C)=O)=NC=C(Br)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H318-H335 |
| Precautionary statements | P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Hazard Note | Irritant/Keep Cold |
| HS Code | 2933399990 |
TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VIB30608 | tert-Butyl 5-bromopyridine-2-carboxylate | 845306-08-3 | 10g | $354 | 2026-06-05 | Buy |
| Apolloscientific | OR3355 | tert-Butyl 5-bromopyridine-2-carboxylate 97% | 845306-08-3 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR3355 | tert-Butyl 5-bromopyridine-2-carboxylate 97% | 845306-08-3 | 1g | $32 | 2026-06-04 | Buy |
| Apolloscientific | OR3355 | tert-Butyl 5-bromopyridine-2-carboxylate 97% | 845306-08-3 | 5g | $154 | 2026-06-04 | Buy |
| Apolloscientific | OR3355 | tert-Butyl 5-bromopyridine-2-carboxylate 97% | 845306-08-3 | 25g | $693 | 2026-06-04 | Buy |
TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 Chemical Properties,Uses,Production
Synthesis
30766-11-1
75-65-0
845306-08-3
The general procedure for the synthesis of tert-butyl 5-bromopyridine-2-carboxylate from 2-carboxylic acid-5-bromopyridine and tert-butanol was as follows: 2-carboxylic acid-5-bromopyridine (118 mg, 0.58 mmol) was mixed with pyridine (0.3 mL, 0.39 mmol) and tert-butanol (1 mL), and p-toluenesulfonyl chloride (262 mg, 1.38 mmol) was subsequently added. The reaction mixture was stirred at 40°C for 10 minutes and then continued to stir at room temperature for 2 hours. After the reaction was completed, saturated sodium bicarbonate solution (4 mL) was added and stirred for 5 minutes. Then diethyl ether was added and the two-phase mixture was stirred for 10 minutes. The organic layer was separated, washed with brine, dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent being pentane: ethyl acetate (100:0 to 80:20) to afford tert-butyl 5-bromopyridine-2-carboxylate as a colorless solid in 73% (110 mg) yield. The product was confirmed by 1H-NMR (CDCl3, 400 MHz): δ 1.65 (s, 9H), 7.95 (m, 2H), 8.88 (m, 1H). The mass spectrum (ES+) showed m/z 539 [M2Na]+.
References
[1] Patent: EP1595881, 2005, A1. Location in patent: Page/Page column 62
[2] Patent: WO2005/14571, 2005, A1. Location in patent: Page/Page column 27
[3] Patent: WO2006/29906, 2006, A1. Location in patent: Page/Page column 16-17
[4] Patent: WO2012/143599, 2012, A1. Location in patent: Page/Page column 47-48
TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 Preparation Products And Raw materials
TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20725 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
View Lastest Price from TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98
845306-08-3
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-13 | Tert-Butyl 5-Bromopyridine-2-Carboxylate
845306-08-3
|
1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd |
-
- TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98
845306-08-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Tert-Butyl 5-Bromopyridine-2-Carboxylate
845306-08-3
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
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