ChemicalBook >> CAS DataBase List >>R-(+)-DIOA
R-(+)-DIOA
- CAS No.
- 81166-47-4
- Chemical Name:
- R-(+)-DIOA
- Synonyms
- R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor;Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]-;R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
- CBNumber:
- CB7506132
- Molecular Formula:
- C20H24Cl2O4
- Molecular Weight:
- 399.31
- MDL Number:
- MFCD00069261
- MOL File:
- 81166-47-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-04-24 14:58:33
| Product description | Number | Pack Size | Price |
| R-(+)-DIOA ≥98% (HPLC), solid | D129 | 10mg | $352 |
| R-(+)-DIOA ≥98% (HPLC), solid | D129 | 50mg | $1150 |
| R-(+)-DIOA ≥98%(HPLC) | 463424 | 5mg | $463 |
| R-(+)-DIOA ≥98%(HPLC) | 463424 | 10mg | $785 |
| DIOA 99.1% | CS-0136819 | 1mg | $531 |
| Melting point | 173-174 °C |
|---|---|
| Boiling point | 562.2±50.0 °C(Predicted) |
| Density | 1.307±0.06 g/cm3(Predicted) |
| solubility | H2O: insoluble <0.11mg/mL |
| form | solid |
| pka | 2.80±0.10(Predicted) |
| color | white |
| optical activity | [α]27/D +18.1°, c = 0.7 in methanol(lit.) |
| Water Solubility |
H2O: insoluble <0.11mg/mL DMSO: >20mg/mL 0.1 M HCl: insoluble 0.1 M NaOH: soluble ethanol: soluble |
| InChI | 1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1 |
| InChIKey | YAWWQIFONIPBKT-FQEVSTJZSA-N |
| SMILES | CCCC[C@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
R-(+)-DIOA price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D129 | R-(+)-DIOA ≥98% (HPLC), solid | 81166-47-4 | 10mg | $352 | 2026-04-30 | Buy |
| Sigma-Aldrich | D129 | R-(+)-DIOA ≥98% (HPLC), solid | 81166-47-4 | 50mg | $1150 | 2026-04-30 | Buy |
| Usbiological | 463424 | R-(+)-DIOA ≥98%(HPLC) | 81166-47-4 | 5mg | $463 | 2026-06-03 | Buy |
| Usbiological | 463424 | R-(+)-DIOA ≥98%(HPLC) | 81166-47-4 | 10mg | $785 | 2026-06-03 | Buy |
| ChemScene | CS-0136819 | DIOA 99.1% | 81166-47-4 | 1mg | $531 | 2026-06-04 | Buy |
R-(+)-DIOA Chemical Properties,Uses,Production
Uses
R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system.
Uses
R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
- short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
- uptake of grepafloxacin by THP-1 monocytes
- the uptake of moxifloxacin by THP-1 monocytes
Biochem/physiol Actions
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl)co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.
Synthesis of R-(+)-DIOA from Acetic acid, 2-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-
R-(+)-DIOA Preparation Products And Raw materials
R-(+)-DIOA Suppliers
Global( 16)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29845 | 58 |
| Enzo Biochem Inc | -- | Enzoname@qq.com | China | 6174 | 58 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6394 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6594 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| Sigma-Aldrich | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Enzo Biochem Inc | 58 |
| Merck KGaA | 58 |
| Santa Cruz Biotechnology Inc | 58 |
81166-47-4(R-(+)-DIOA)Related Search:
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1of4
R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid
Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]-
R-(+)-DIOA (R(+)-Butylindazone), K+/Cl--cotransporter inhibitor
81166-47-4
C20H24Cl2O4
