Source

Rabbit

Reactivity

Mouse;Rat

Background

The Kazal type 3 serine peptidase inhibitor is a serine peptidase inhibitor expressed in the adult pancreas that protects acinar cells from trypsin-induced cell damage. Ingestion of milk by newborn SPINK3 knock out mice triggers autophagic cell death in pancreatic acinar cells and the complete disappearance of the pancreas. Mutations in the human SPINK3 homolog are associated with chronic pancreatitis, presumably through decreased protection against trypsin-induced autophagic cell death. SPINK3 may be involved in the embryonic development of several other tissues.

References

[1] Whitcomb, D.C. et al. (1996) Nat Genet 14, 141-5.
[2] Ohmuraya, M. et al. (2005) Gastroenterology 129, 696-705.
[3] Hirota, M. et al. (2006) J Gastroenterol 41, 832-6.
[4] Wang, J. et al. (2008) Histochem Cell Biol 130, 387-97.

Raw materials

Preparation Products