ChemicalBook >> CAS DataBase List >>Methotrexate α-tert-Butyl Ester
Methotrexate α-tert-Butyl Ester
- CAS No.
- 79640-70-3
- Chemical Name:
- Methotrexate α-tert-Butyl Ester
- Synonyms
- Methotrexate Impurity 8;Methotrexate a-tert-Butyl Ester;Methotrexate α-tert-Butyl Ester;(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid;L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(1,1-dimethylethyl) ester
- CBNumber:
- CB76091801
- Molecular Formula:
- C24H30N8O5
- Molecular Weight:
- 510.55
- MDL Number:
- MFCD32868559
- MOL File:
- 79640-70-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-04-24 14:59:07
| Product description | Number | Pack Size | Price |
| Methotrexate α-tert-Butyl Ester | 454502 | 10mg | $382 |
| Methotrexate α-tert-Butyl Ester | 454502 | 25mg | $609 |
| Methotrexate a-tert-Butyl Ester | TRC-M260750-25MG | 25mg | $283 |
| Methotrexate a-tert-Butyl Ester | TRC-M260750-100MG | 100mg | $904 |
| Methotrexate α-tert-butyl ester 97.38% | CS-0134856 | 5mg | $303 |
| Melting point | >211°C (dec.) |
|---|---|
| Density | 1.377±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 4.43±0.10(Predicted) |
| color | Pale Yellow to Orange |
| InChIKey | HTMMDBDGHQUHPW-INIZCTEOSA-N |
| SMILES | NC1=NC(=NC2N=CC(=NC=21)CN(C1C=CC(=CC=1)C(=O)N[C@@H](CCC(=O)O)C(=O)OC(C)(C)C)C)N |
Methotrexate α-tert-Butyl Ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 454502 | Methotrexate α-tert-Butyl Ester | 79640-70-3 | 10mg | $382 | 2026-06-03 | Buy |
| Usbiological | 454502 | Methotrexate α-tert-Butyl Ester | 79640-70-3 | 25mg | $609 | 2026-06-03 | Buy |
| TRC | TRC-M260750-25MG | Methotrexate a-tert-Butyl Ester | 79640-70-3 | 25mg | $283 | 2026-06-03 | Buy |
| TRC | TRC-M260750-100MG | Methotrexate a-tert-Butyl Ester | 79640-70-3 | 100mg | $904 | 2026-06-03 | Buy |
| ChemScene | CS-0134856 | Methotrexate α-tert-butyl ester 97.38% | 79640-70-3 | 5mg | $303 | 2026-06-04 | Buy |
Methotrexate α-tert-Butyl Ester Chemical Properties,Uses,Production
Uses
Methotrexate α-tert-Butyl Ester is an intermediate to the synthesis of folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.
in vivo
Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice[1].
The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo[1].
| Animal Model: | Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells)[1] |
| Dosage: | 30 mg/kg |
| Administration: | Once per week for 2 weeks |
| Result: | Showed a significant (63%) reduction in tumor size on day 12. |
Synthesis of Methotrexate α-tert-Butyl Ester from L-Glutamic acid α-tert·butyl ester and 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID
Methotrexate α-tert-Butyl Ester Preparation Products And Raw materials
Raw materials
Preparation Products
Methotrexate α-tert-Butyl Ester Suppliers
Global( 39)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 6000 | 58 |
| Tianjin shanhaijing medicine technology co., ltd | 19129375004; 15321929114 | yangtzechem@163.com | China | 501 | 58 |
| ChemShuttle, Inc. | 0510-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4841 | 55 | |
| Shanghai GL Peptide Ltd. | +86-21-61263340; 17609490614 13764994101 | fisherwang@glschina.com | China | 8252 | 55 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2995 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 19372819560 | Sales@ATKchemical.com | China | 9627 | 58 |
Methotrexate α-tert-Butyl Ester
(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(1,1-dimethylethyl) ester
Methotrexate a-tert-Butyl Ester
Methotrexate Impurity 8
79640-70-3
