2-Chloro-4-cyanopyridine
- CAS No.
- 33252-30-1
- Chemical Name:
- 2-Chloro-4-cyanopyridine
- Synonyms
- 2-CHLOROISONICOTINONITRILE;2-CHLOROPYRIDINE-4-CARBONITRILE;2-CHLORO-4-PYRIDINECARBONITRILE;2-4 - cyanopyridine chloride -;2-CHLORO-4-CYANOPYRIDINE 2-CHLORO-ISONICOTINONITRILE;2-Chloro-4-pyridinecarbonitrile,2-Chloro-4-cyanopyridine;Compound Fr13742;BUTTPARK 43\57-01;2-Chloro-4-cyanopyri;6-Chloro-4-cyanopyridine
- CBNumber:
- CB7673984
- Molecular Formula:
- C6H3ClN2
- Molecular Weight:
- 138.55
- MDL Number:
- MFCD00174318
- MOL File:
- 33252-30-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Chloro-4-pyridinecarbonitrile 97% | 548227 | 25g | $151 |
| 2-Chloro-4-pyridinecarbonitrile 97% | 548227 | 5g | $37 |
| 2-Chloro-4-cyanopyridine >98.0%(GC) | C1873 | 5g | $53 |
| 2-Chloro-4-cyanopyridine >98.0%(GC) | C1873 | 25g | $119 |
| 2-Chloro-4-cyanopyridine | 416730 | 1g | $319 |
| More product size | |||
| Melting point | 69-73 °C(lit.) |
|---|---|
| Boiling point | 104-106°C 15mm |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Flash point | 104-106°C/15mm |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | -1.60±0.10(Predicted) |
| color | White to Almost white |
| BRN | 113927 |
| InChI | InChI=1S/C6H3ClN2/c7-6-3-5(4-8)1-2-9-6/h1-3H |
| InChIKey | QRXBTPFMCTXCRD-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC(C#N)=C1 |
| CAS DataBase Reference | 33252-30-1(CAS DataBase Reference) |
| FDA UNII | U2S8C7U4ER |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39-36/37 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Chloro-4-cyanopyridine price More Price(101)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 548227 | 2-Chloro-4-pyridinecarbonitrile 97% | 33252-30-1 | 25g | $151 | 2026-04-30 | Buy |
| Sigma-Aldrich | 548227 | 2-Chloro-4-pyridinecarbonitrile 97% | 33252-30-1 | 5g | $37 | 2023-06-20 | Buy |
| TCI Chemical | C1873 | 2-Chloro-4-cyanopyridine >98.0%(GC) | 33252-30-1 | 5g | $53 | 2026-04-30 | Buy |
| TCI Chemical | C1873 | 2-Chloro-4-cyanopyridine >98.0%(GC) | 33252-30-1 | 25g | $119 | 2026-04-30 | Buy |
| Usbiological | 416730 | 2-Chloro-4-cyanopyridine | 33252-30-1 | 1g | $319 | 2026-06-03 | Buy |
2-Chloro-4-cyanopyridine Chemical Properties,Uses,Production
Chemical Properties
White to off-white solid
Uses
2-Chloro-4-cyanopyridine is an intermediate used to prepare pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). It is also used to synthesize pyridinyl-tetrazoles as scaffold to identify matrix MMP-13 inhibitors for treatment of osteoarthritis.
Materials Uses
2-Chloro-4-cyanopyridine is employed in the formulation of advanced materials, including polymers and coatings, offering improved durability and chemical resistance compared to similar compounds.
Synthesis
14906-59-3
33252-30-1
The general procedure for the synthesis of 2-chloro-4-cyanopyridine from 4-cyanopyridine N-oxide was as follows: 120 g of 4-cyanopyridine-N-oxide, 360 mL of 1,2-dichloroethane, and 183.6 g of phosphorochloridic acid were added sequentially in a 1000 mL three-necked reaction flask. After the reaction system was cooled to -2±2°C, 151.5 g of triethylamine was added slowly dropwise for a controlled dropwise time of 2 hours. After the dropwise addition, the reaction was continued at the same temperature with stirring for 2 hours. Upon completion of the reaction, the reaction solution was concentrated by reduced pressure distillation until no fractions flowed out. 240 mL of water was added to the concentrated solution and a large amount of solid was precipitated after thorough stirring. The solid was collected by filtration and the filter cake was washed with appropriate amount of water to obtain 117.5 g of white solid product 2-chloro-4-cyanopyridine.
References
[1] Tetrahedron Letters, 2001, vol. 42, # 39, p. 6815 - 6818
[2] Patent: CN104945383, 2017, B. Location in patent: Paragraph 0031; 0035; 0036
2-Chloro-4-cyanopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Dowell Chemical Co.,Ltd | +8618633820607 | sell@dowechem.com | China | 89 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 281 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 | |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
Related articles
- Preparation of 2-Chloro-4-cyanopyridine
- 2-Chloro-4-cyanopyridine is an important organic intermediate to synthetize substituted pyridines.
- Nov 5，2019
View Lastest Price from 2-Chloro-4-cyanopyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-06-25 | 2-Chloro-4-cyanopyridine
33252-30-1
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | 2-Chloro-4-cyanopyridine
33252-30-1
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2021-07-13 | 2-Chloro-4-cyanopyridine
33252-30-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Chloro-4-cyanopyridine
33252-30-1
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Chloro-4-cyanopyridine
33252-30-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Chloro-4-cyanopyridine
33252-30-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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