5-METHOXY-3,4-DIHYDRO-2H-PYRROLE
- CAS No.
- 5264-35-7
- Chemical Name:
- 5-METHOXY-3,4-DIHYDRO-2H-PYRROLE
- Synonyms
- 3,4-dihydro-5-methoxy-2H-Pyrrole;c-C4H6N(2-OCH3);2-methoxypyrrole;AKOS BBS-00007016;2-METHOXY-1-PYRROLINE;Tipiracil Impurity 16;Piracetam EP Impurity 5;2-Methoxy-1-pyrrolidine;4,5-Dihydro-2-methoxy-3H-pyrrole;5-METHOXY-3,4-DIHYDRO-2H-PYRROLE
- CBNumber:
- CB7703937
- Molecular Formula:
- C5H9NO
- Molecular Weight:
- 99.13
- MDL Number:
- MFCD01821272
- MOL File:
- 5264-35-7.mol
| Product description | Number | Pack Size | Price |
| 5-Methoxy-3,4-dihydro-2H-pyrrole | FM129804 | 50g | $900 |
| 5-Methoxy-3,4-dihydro-2H-pyrrole | FM129804 | 100g | $900 |
| 5-Methoxy-3,4-dihydro-2H-pyrrole >98% | M69559 | 1g | $23 |
| 5-Methoxy-3,4-dihydro-2H-pyrrole >98% | M69559 | 5g | $29 |
| 5-Methoxy-3,4-dihydro-2H-pyrrole >98% | M69559 | 10g | $50 |
| Boiling point | 118-121 °C |
|---|---|
| Density | 1.05±0.1 g/cm3(Predicted) |
| refractive index | 1.4375 |
| storage temp. | 2-8°C |
| pka | 6.29±0.20(Predicted) |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C5H9NO/c1-7-5-3-2-4-6-5/h2-4H2,1H3 |
| InChIKey | QYGNDKJRRNVSEC-UHFFFAOYSA-N |
| SMILES | N1=C(OC)CCC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HazardClass | IRRITANT |
5-METHOXY-3,4-DIHYDRO-2H-PYRROLE price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM129804 | 5-Methoxy-3,4-dihydro-2H-pyrrole | 5264-35-7 | 50g | $900 | 2026-06-04 | Buy |
| Biosynth | FM129804 | 5-Methoxy-3,4-dihydro-2H-pyrrole | 5264-35-7 | 100g | $900 | 2026-06-04 | Buy |
| Synthonix | M69559 | 5-Methoxy-3,4-dihydro-2H-pyrrole >98% | 5264-35-7 | 1g | $23 | 2026-05-06 | Buy |
| Synthonix | M69559 | 5-Methoxy-3,4-dihydro-2H-pyrrole >98% | 5264-35-7 | 5g | $29 | 2026-05-06 | Buy |
| Synthonix | M69559 | 5-Methoxy-3,4-dihydro-2H-pyrrole >98% | 5264-35-7 | 10g | $50 | 2026-05-06 | Buy |
5-METHOXY-3,4-DIHYDRO-2H-PYRROLE Chemical Properties,Uses,Production
Uses
2-Methoxy-1-pyrroline acts as a reagent in the design and preparation of dihydroindolones and dihydroindolizinones as orally available MEK inhibitors with potent in vivo antitumor efficacy. Synthesis and anti-HSV activity of methylenedioxy mappicine ketone analogs against herpes viruses.
Synthesis
616-45-5
77-78-1
5264-35-7
General procedure for the synthesis of 2-methoxy-1-pyrrolidine from 2-pyrrolidone and dimethyl sulfate: 23 mL (1 equiv.) of dimethyl sulfate was added slowly and dropwise to a solution of 20.03 g (0.235 mol) of 2-pyrrolidone dissolved in 85 mL of benzene, after which the reaction mixture was heated to 70 °C and kept at reflux for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and then 19 mL of 15 N sodium hydroxide solution was added. The reaction mixture was transferred to a partition funnel and the aqueous phase was extracted three times with benzene. The organic phases were combined and dried over anhydrous sodium sulfate, followed by evaporation of the solvent under reduced pressure. The residue was purified by vacuum distillation to afford 2-methoxy-1-pyrrolidine as a colorless liquid in 58% yield. The boiling point of the product was 37 °C (10^-2 mbar).1H NMR (CDCl3, 100 MHz) data were as follows: δ 1.97 (m, 2H), 2.41 (t, 2H), 3.61 (t, 2H), 3.75 (s, 3H).
References
[1] Arkivoc, 2016, vol. 2016, # 5, p. 118 - 141
[2] Journal of Organic Chemistry, 1995, vol. 60, # 9, p. 2912 - 2915
[3] Organic Preparations and Procedures International, 1992, vol. 24, # 2, p. 147 - 158
[4] Journal of Medicinal Chemistry, 2001, vol. 44, # 10, p. 1588 - 1593
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 25, p. 6307 - 6315
5-METHOXY-3,4-DIHYDRO-2H-PYRROLE Preparation Products And Raw materials
5-METHOXY-3,4-DIHYDRO-2H-PYRROLE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
View Lastest Price from 5-METHOXY-3,4-DIHYDRO-2H-PYRROLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | 5-methoxy-3,4-dihydro-2h-pyrrole
5264-35-7
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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- 5-methoxy-3,4-dihydro-2h-pyrrole
5264-35-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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