Mandelonitrile
- CAS No.
- 532-28-5
- Chemical Name:
- Mandelonitrile
- Synonyms
- 2-Hydroxy-2-phenylacetonitrile;MANDELONITRILE;Amygdalonitrile;Mandelonitrile>MANDELONITRILE 98%;-Cyanobenzylalcohol;Mandelonitrile ,95%;Phenylglycolonitrile;phenyl-glycolonitril;Mandelonitrile,>98%,
- CBNumber:
- CB7853744
- Molecular Formula:
- C8H7NO
- Molecular Weight:
- 133.15
- MDL Number:
- MFCD00004487
- MOL File:
- 532-28-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| DL-Mandelic acid nitrile for synthesis | 8.19016 | 100mL | $106 |
| Mandelonitrile technical grade | 116025 | 50g | $40 |
| DL-Mandelic acid nitrile for synthesis | 8.19016 | 250ML | $222 |
| Mandelonitrile >97.0%(GC) | M0566 | 25g | $21 |
| Mandelonitrile (>90%) | TRC-M162560-5G | 5g | $90 |
| More product size | |||
| Melting point | -10 °C |
|---|---|
| Boiling point | 170 °C(lit.) |
| Density | 1.117 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 207 °F |
| storage temp. | Store below +30°C. |
| solubility | alcohol: freely soluble |
| form | Liquid |
| pka | 10.50±0.20(Predicted) |
| color | Yellow to brown |
| Water Solubility | <1g/L |
| Sensitive | Moisture Sensitive |
| Merck | 14,5719 |
| BRN | 2207122 |
| Dielectric constant | 17.0（23℃） |
| Stability | Stable, but moisture sensitive. Combustible. Incompatible with strong oxidizing agents. |
| InChI | 1S/C8H7NO/c9-6-8(10)7-4-2-1-3-5-7/h1-5,8,10H |
| InChIKey | NNICRUQPODTGRU-UHFFFAOYSA-N |
| SMILES | N#CC(O)c1ccccc1 |
| LogP | 0.830 (est) |
| CAS DataBase Reference | 532-28-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 584322E08A |
| NIST Chemistry Reference | Benzeneacetonitrile, «alpha»-hydroxy-(532-28-5) |
| EPA Substance Registry System | Mandelonitrile (532-28-5) |
| UNSPSC Code | 12352117 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H315-H318 | |||||||||
| Precautionary statements | P501-P261-P270-P271-P264-P280-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P305+P351+P338+P310-P403+P233-P405 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25-41 | |||||||||
| Safety Statements | 22-26-36/37/39-45-24/25 | |||||||||
| RIDADR | UN 3276 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OO8400000 | |||||||||
| F | 21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2926 90 70 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| Storage Class | 6.1C - Combustible, acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Eye Dam. 1 |
|||||||||
| Toxicity | LD50 orally in Rabbit: 116 mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Mandelonitrile price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.19016 | DL-Mandelic acid nitrile for synthesis | 532-28-5 | 100mL | $106 | 2026-04-30 | Buy |
| Sigma-Aldrich | 116025 | Mandelonitrile technical grade | 532-28-5 | 50g | $40 | 2023-06-20 | Buy |
| Sigma-Aldrich | 8.19016 | DL-Mandelic acid nitrile for synthesis | 532-28-5 | 250ML | $222 | 2023-01-07 | Buy |
| TCI Chemical | M0566 | Mandelonitrile >97.0%(GC) | 532-28-5 | 25g | $21 | 2026-04-30 | Buy |
| TRC | TRC-M162560-5G | Mandelonitrile (>90%) | 532-28-5 | 5g | $90 | 2026-06-03 | Buy |
Mandelonitrile Chemical Properties,Uses,Production
Chemical Properties
reddish-brown liquid. D,L-Mandelonitrile [532-28-5], benzaldehyde cyanohydrin, a-cyano-a-hydroxymethylbenzene, C6H5 – CH(OH) – CN, Mr 133.15, mp-10℃, d204 1.1165 – 1.120, is miscible with ethanol and diethyl ether, immiscible with water. Mandelonitrile occurs naturally as the bglycoside of gentiobiose (amygdalin). It decomposes on heating into benzaldehyde and hydrogen cyanide. It is produced from benzaldehyde and alkali cyanide in the presence of mineral acid. Mandelonitrile is used as an intermediate in the production of mandelic acid.
Occurrence
Mandelonitrile, is a yellow, oily liquid, insoluble in water, but soluble in alcohol and diethyl ether. Mandelonitrile is a component of the glycoside amygdalin, a precursor of laetrile found in the leaves and seeds on most Prunus species (plum, peach, apricot, etc). In 1832, mandelonitrile was the first cyanohydrin to be synthesized. It is commercially prepared from benzaldehyde and hydrogen cyanide. Mandelonitrile is used by certain insects (tiger beetles, an African millipede) as a defense fluid. After expelling the fluid an enzyme catalyzes the conversion of mandelonitrile to benzaldehyde and HCN, which is usually fatal to the insect’s enemy.
Uses
Mandelonitrile has been used to extract mandeloamide by the nitrilase variants.
Definition
ChEBI: Mandelonitrile is a cyanohydrin that is phenylacetonitrile in which one of the methylene hydrogens is replaced by a hydroxy group.
General Description
Reddish-brown to dark red-brown liquid.
Air & Water Reactions
Mandelonitrile is sensitive to moisture. . Insoluble in water.
Reactivity Profile
Nitriles, such as Mandelonitrile, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Mandelonitrile is combustible.
Safety Profile
Poison by intravenous and subcutaneous routes. Mutation data reported. A severe eye irritant. When heated to decomposition it emits toxic fumes of NOx and CN-. See also NITRILES.
Toxicology
Mandelonitrile is rather toxic with an LD50 value (rat, oral) of 116 mg/kg. This high toxicity may be due to the equilibrium of the cyanohydrin with benzaldehyde and hydrogen cyanide.
Mandelonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
View Lastest Price from Mandelonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-19 | Mandelonitrile
532-28-5
|
$3.00 | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co |
-
- Mandelonitrile
532-28-5
- $3.00
- 98%
- Career Henan Chemical Co
