1,2,3,4-Tetrahydroisoquinoline-1,3-dione
- CAS No.
- 4456-77-3
- Chemical Name:
- 1,2,3,4-Tetrahydroisoquinoline-1,3-dione
- Synonyms
- FR 038470;NSC 409146;homophtalic-imide;ine-1,3(2H,4H)-dione;1,3-ISOQUINOLINEDIOL;Isoquinoline-1,3(2H,4H);4H-Isoquinoline-1,3-dione;2H,4H-1,3-Isoquinolinedione;1,3-[2H,4H]-Isoquinolinedione;2,4-dihydroisoquinoline-1,3-dione
- CBNumber:
- CB7967269
- Molecular Formula:
- C9H7NO2
- Molecular Weight:
- 161.16
- MDL Number:
- MFCD00234966
- MOL File:
- 4456-77-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1,3[2H,4H]-Isoquinolinedione 98%(HPLC) | W6338 | 1g | $28 |
| 1,3[2H,4H]-Isoquinolinedione 98%(HPLC) | W6338 | 5g | $95 |
| 1,3[2H,4H]-Isoquinolinedione 98%(HPLC) | W6338 | 100g | $161 |
| 1,3[2H,4H]-Isoquinolinedione 95% | J56245 | 1g | $21 |
| 1,3[2H,4H]-Isoquinolinedione 95% | J56245 | 5g | $71 |
| Melting point | 223 °C |
|---|---|
| Boiling point | 377.1±35.0 °C(Predicted) |
| Density | 1.286±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 10.25±0.20(Predicted) |
| Appearance | Off-white to yellow Solid |
| FDA UNII | 36C8TUT4R4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 |
| HS Code | 2933499090 |
1,2,3,4-Tetrahydroisoquinoline-1,3-dione price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | W6338 | 1,3[2H,4H]-Isoquinolinedione 98%(HPLC) | 4456-77-3 | 1g | $28 | 2026-06-04 | Buy |
| AK Scientific | W6338 | 1,3[2H,4H]-Isoquinolinedione 98%(HPLC) | 4456-77-3 | 5g | $95 | 2026-06-04 | Buy |
| AK Scientific | W6338 | 1,3[2H,4H]-Isoquinolinedione 98%(HPLC) | 4456-77-3 | 100g | $161 | 2026-06-04 | Buy |
| AK Scientific | J56245 | 1,3[2H,4H]-Isoquinolinedione 95% | 4456-77-3 | 1g | $21 | 2026-06-04 | Buy |
| AK Scientific | J56245 | 1,3[2H,4H]-Isoquinolinedione 95% | 4456-77-3 | 5g | $71 | 2026-06-04 | Buy |
1,2,3,4-Tetrahydroisoquinoline-1,3-dione Chemical Properties,Uses,Production
Uses
Isoquinoline-1,3(2H,4H)-dione can be useful in the discovery and development of labdane-oxindole hybrids as small-molecule inhibitors against chikungunya virus infection in human HeLa cells.
Synthesis
89-51-0
4456-77-3
O-carboxyphenylacetic acid (20.0 g, 111 mmol) was mixed with finely ground urea (7.33 g, 122 mmol) and the reaction was heated at 175-185 °C for 2 hours. After completion of the reaction, the mixture was cooled and purified by recrystallization from methanol to give 1,3-[2H,4H]-isoquinolinedione (12.0 g, 67% yield) as a white solid with a melting point of 220-222 °C (literature value 3: 236-238 °C). The structure of the product was confirmed by 1H NMR and 13C NMR: 1H NMR ((CD3)2SO) δ 4.09 (3H, s, CH2), 7.44 (1H, d, J = 7.6 Hz, 5-H), 7.51 (1H, t, J = 7.6 Hz, 7-H), 7.70 (1H, td, J = 7.6, 1.2 Hz, 6-H). 8.07 (1H, dd, J = 7.8, 1.1 Hz, 8-H), 11.36 (1H, s, NH); 13C NMR ((CD3)2SO) (HSQC/HMBC) δ 35.92 (4-C), 124.95 (8a-C), 127.16 (7-C), 127.41 (8-C), 127.87 (5-C) , 133.47 (6-C), 136.66 (4a-C), 165.34 (1-C), 170.99 (3-C).
References
[1] Liebigs Annalen der Chemie, 1981, # 5, p. 811 - 818
[2] Synthetic Communications, 1998, vol. 28, # 17, p. 3195 - 3200
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5891 - 5908
[4] Synthetic Communications, 1981, vol. 11, # 6, p. 447 - 454
[5] Patent: EP2441755, 2012, A1. Location in patent: Paragraph 0172
1,2,3,4-Tetrahydroisoquinoline-1,3-dione Preparation Products And Raw materials
1,2,3,4-Tetrahydroisoquinoline-1,3-dione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9070 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1299 | 58 |
View Lastest Price from 1,2,3,4-Tetrahydroisoquinoline-1,3-dione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | 1,2,3,4-Tetrahydroisoquinoline-1,3-dione
4456-77-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 1,2,3,4-Tetrahydroisoquinoline-1,3-dione
4456-77-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 1,2,3,4-Tetrahydroisoquinoline-1,3-dione
4456-77-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1,2,3,4-Tetrahydroisoquinoline-1,3-dione
4456-77-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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