Isochlorogenic acid A
- CAS No.
- 2450-53-5
- Chemical Name:
- Isochlorogenic acid A
- Synonyms
- 3,5-Dicaffeoylquinic acid;3,5-CQA;CJ 4-16-4;Isochloric acid A;Isochlorogenic acid A;3,5-Dicaffeylquinic acid;ISOCHLOROGENIC ACID A(SH);3',5'-Isochlorogenic acid A;3,5-Dicaffeoylquinic acid-RM;Quinic acid 3,5-di-O-caffeate
- CBNumber:
- CB81040694
- Molecular Formula:
- C25H24O12
- Molecular Weight:
- 516.46
- MDL Number:
- MFCD00951290
- MOL File:
- 2450-53-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3,5-Di-caffeoylquinic acid ≥95% (LC/MS-ELSD) | SMB00131 | 1mg | $345 |
| 3,5-Dicaffeoylquinic acid phyproof Reference Substance | PHL80426 | 10mg | $572 |
| 3,5-Dicaffeoylquinic Acid ≥95% | 24964 | 5mg | $87 |
| 3,5-Dicaffeoylquinic Acid ≥95% | 24964 | 10mg | $156 |
| 3,5-Dicaffeoylquinic Acid ≥95% | 24964 | 25mg | $344 |
| More product size | |||
| Melting point | >175°C (dec.) |
|---|---|
| Boiling point | 826.2±65.0 °C(Predicted) |
| Density | 1+-.0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.54±0.50(Predicted) |
| form | Off-white to yellow/brown crystalline solid. |
| color | Off-White to Pale Yellow |
| Stability | Hygroscopic |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChIKey | KRZBCHWVBQOTNZ-PSEXTPKNSA-N |
| SMILES | O([C@@H]1C[C@](O)(C(=O)O)C[C@@H](OC(=O)C=CC2C=CC(O)=C(O)C=2)[C@H]1O)C(=O)C=CC1C=CC(O)=C(O)C=1 |&1:1,3,9,23,r| |
| FDA UNII | ND94C5E75K |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS | GU8403966 |
| HS Code | 29189900 |
| Storage Class | 11 - Combustible Solids |
Isochlorogenic acid A price More Price(100)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00131 | 3,5-Di-caffeoylquinic acid ≥95% (LC/MS-ELSD) | 2450-53-5 | 1mg | $345 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL80426 | 3,5-Dicaffeoylquinic acid phyproof Reference Substance | 2450-53-5 | 10mg | $572 | 2026-04-30 | Buy |
| Cayman Chemical | 24964 | 3,5-Dicaffeoylquinic Acid ≥95% | 2450-53-5 | 5mg | $87 | 2026-04-30 | Buy |
| Cayman Chemical | 24964 | 3,5-Dicaffeoylquinic Acid ≥95% | 2450-53-5 | 10mg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 24964 | 3,5-Dicaffeoylquinic Acid ≥95% | 2450-53-5 | 25mg | $344 | 2026-04-30 | Buy |
Isochlorogenic acid A Chemical Properties,Uses,Production
Description
3,5-Dicaffeoylquinic acid (3,5-DCQA) is a natural phenolic compound that has been found in L. japonica, I. kaushue, and other plants. It has antioxidant, anti-inflammatory, and antiviral biological activities. 3,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay (IC50 = 71.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B (IC50 = 1.92 μM). It inhibits HIV-1 integrase 3''-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively) and inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml). In vivo, 3,5-DCQA (25 mg/kg) protects mice from acute lung injury induced by LPS and decreases neutrophil count in bronchoalveolar lavage fluid (BALF).
Chemical Properties
Off-white crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from honeysuckle, honeysuckle, eucommia, and chrysanthemum.
Uses
Isochlorogenic Acid A is a phenolic compound shown to provide protection against oxidative stress cells. DNA protective agent.
Definition
ChEBI: 3,5-di-O-caffeoyl quinic acid is a carboxylic ester that is the diester obtained by the condensation of the hydroxy groups at positions 3 and 5 of (-)-quinic acid with the carboxy group of trans-caffeic acid. Isolated from Brazilian propolis and Suaeda glauca, it exhibits hepatoprotective and cytotoxic activities. It has a role as a metabolite, a hepatoprotective agent and an antineoplastic agent. It is a cyclitol carboxylic acid and a carboxylic ester. It is functionally related to a (-)-quinic acid and a trans-caffeic acid.
in vivo
Isochlorogenic acid A (5and 10 mg/kg, p.o., once a day for 3 weeks) ameliorates cognitive impairment induced by TMT in ICR male mice[5].
| Animal Model: | TMT-induced ICR male mice[5] |
| Dosage: | 5and 10 mg/kg |
| Administration: | p.o., once a day for 3 weeks |
| Result: | Improved spatial memory and learning ability of mice in MWM test. Reduced the TMT-induced increased AChE activity. Reduced the MDA content compared to the TMT group. |
References
[1] LI-YAN PENG. Constituents from Lonicera japonica[J]. Fitoterapia, 2000, 71 6: Pages 713-715. DOI: 10.1016/s0367-326x(00)00212-4
[2] KRISS DAYANA PANTOJA PULIDO José H I M Ana Julia Colmenares Dulcey. New caffeic acid derivative from Tithonia diversifolia (Hemsl.) A. Gray butanolic extract and its antioxidant activity[J]. Food and Chemical Toxicology, 2017, 109: Pages 1079-1085. DOI: 10.1016/j.fct.2017.03.059
[3] W E ROBINSON. Inhibitors of HIV-1 replication [corrected; erratum to be published] that inhibit HIV integrase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 13: 6326-6331. DOI: 10.1073/pnas.93.13.6326
Isochlorogenic acid A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 4616 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
View Lastest Price from Isochlorogenic acid A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-26 | Isochlorogenic acid A
2450-53-5
|
$59.00-176.00 | 99.71% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-14 | Isochlorogenic acid A
2450-53-5
|
$1.00 | 1KG | 99% | 25kg | Career Henan Chemical Co |
-
- Isochlorogenic acid A
2450-53-5
- $59.00-176.00
- 99.71%
- TargetMol Chemicals Inc.
-
- Isochlorogenic acid A
2450-53-5
- $1.00
- 99%
- Career Henan Chemical Co
