tert-Butyl (4-methylpiperidin-4-yl)carbamate
- CAS No.
- 163271-08-7
- Chemical Name:
- tert-Butyl (4-methylpiperidin-4-yl)carbamate
- Synonyms
- 4-(Boc-amino)-4-methylpip...;4-Methylpiperidin-4-yl)carbami;4-(Boc-aMino)-4-Methylpiperidine;tert-Butyl (4-methylpiperidin-4-yl);4-Amino-4-methylpiperidine, 4-BOC protected;tert-Butyl N-(4-Methyl-4-piperidyl)carbaMate;tert-Butyl (4-methylpiperidin-4-yl)carbamate;tert-Butyl (4-methyl-4-piperidinyl)carbamate;tert-butyl N-(4-methylpiperidin-4-yl)carbamate;N-(4-Methylpiperidin-1-yl)(tert-butoxy)forMaMide
- CBNumber:
- CB81501982
- Molecular Formula:
- C11H22N2O2
- Molecular Weight:
- 214.3
- MDL Number:
- MFCD08703167
- MOL File:
- 163271-08-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| tert-Butyl (4-Methylpiperidin-4-yl)carbamate min. 98.0 % | D6495 | 1G | $56 |
| tert-Butyl (4-Methylpiperidin-4-yl)carbamate min. 98.0 % | D6495 | 5G | $168 |
| 4-Amino-4-methylpiperidine, 4-BOC protected 95% | OR308121 | 1g | $21 |
| 4-Amino-4-methylpiperidine, 4-BOC protected 95% | OR308121 | 5g | $54 |
| 4-Amino-4-methylpiperidine, 4-BOC protected 95% | OR308121 | 25g | $204 |
| More product size | |||
| Boiling point | 308 °C |
|---|---|
| Density | 1.01 |
| Flash point | 140 °C |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 12.75±0.20(Predicted) |
| form | powder |
| color | Gray |
| InChI | InChI=1S/C11H22N2O2/c1-10(2,3)15-9(14)13-11(4)5-7-12-8-6-11/h12H,5-8H2,1-4H3,(H,13,14) |
| InChIKey | MVUNGZMGWJXPIM-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NC1(C)CCNCC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P280 |
| HS Code | 2933399990 |
tert-Butyl (4-methylpiperidin-4-yl)carbamate price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D6495 | tert-Butyl (4-Methylpiperidin-4-yl)carbamate min. 98.0 % | 163271-08-7 | 1G | $56 | 2026-04-30 | Buy |
| TCI Chemical | D6495 | tert-Butyl (4-Methylpiperidin-4-yl)carbamate min. 98.0 % | 163271-08-7 | 5G | $168 | 2026-04-30 | Buy |
| Apolloscientific | OR308121 | 4-Amino-4-methylpiperidine, 4-BOC protected 95% | 163271-08-7 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR308121 | 4-Amino-4-methylpiperidine, 4-BOC protected 95% | 163271-08-7 | 5g | $54 | 2026-06-04 | Buy |
| Apolloscientific | OR308121 | 4-Amino-4-methylpiperidine, 4-BOC protected 95% | 163271-08-7 | 25g | $204 | 2026-06-04 | Buy |
tert-Butyl (4-methylpiperidin-4-yl)carbamate Chemical Properties,Uses,Production
Uses
tert-Butyl (4-methylpiperidin-4-yl)carbamate is versatile intermediates in organic synthesis, particularly in the pharmaceutical industry. They are used in the synthesis of various compounds, including natural products and potential therapeutic agents.
Synthesis
1262787-56-3
163271-08-7
General procedure for the synthesis of tert-butyl (4-methylpiperidin-4-yl)carbamate from (1-benzoyl-4-methylpiperidin-4-yl)carbamate: 1. tert-Butyl (1-benzoyl-4-methylpiperidin-4-yl)carbamate (318 mg, 1.0 mmol) was dissolved in ethanol (3 mL). 2. 6 N aqueous sodium hydroxide (1.0 mL, 6.0 mmol) was added to the above solution. 3. The reaction mixture was heated at reflux for 8 hours. 4. 4. Upon completion of the reaction, the mixture was concentrated under reduced pressure. 5. Ethyl acetate (30 mL) was added to the concentrated mixture. 6. The organic layer was separated and washed twice with distilled water. 7. Dry the organic layer with anhydrous magnesium sulfate. 8. Concentrate the dried organic layer under reduced pressure and dry under reduced pressure to afford the target product tert-butyl (4-methylpiperidin-4-yl)carbamate (145 mg, 0.67 mmol, 67% yield). Characterization data: Mass spectrum (EI, m/z): 214 [M]+. 1H-NMR (CDCl3) δ: 4.37 (1H, br s), 2.84-2.80 (4H, m), 1.91 (2H, dt, J = 13.3, 3.9 Hz), 1.51 (2H, td, J = 12.9, 6.2 Hz), 1.44 (9H, s), 1.34 (3H, s).
References
[1] Patent: US2012/149902, 2012, A1. Location in patent: Page/Page column 24
tert-Butyl (4-methylpiperidin-4-yl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from tert-Butyl (4-methylpiperidin-4-yl)carbamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-25 | tert-Butyl (4-methylpiperidin-4-yl)carbamate
163271-08-7
|
$100.00 | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | tert-Butyl (4-methylpiperidin-4-yl)carbamate
163271-08-7
|
$100.00 | 1KG | 98% | 10KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2019-07-06 | tert-Butyl (4-methylpiperidin-4-yl)carbamate
163271-08-7
|
$1.00 | 1KG | 99% | 20kg | Career Henan Chemical Co |
-
- tert-Butyl (4-methylpiperidin-4-yl)carbamate
163271-08-7
- $100.00
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- tert-Butyl (4-methylpiperidin-4-yl)carbamate
163271-08-7
- $100.00
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- tert-Butyl (4-methylpiperidin-4-yl)carbamate
163271-08-7
- $1.00
- 99%
- Career Henan Chemical Co
