Quinazoline
- CAS No.
- 253-82-7
- Chemical Name:
- Quinazoline
- Synonyms
- PHENMIAZINE;1,3-BENZODIAZINE;5,6-Benzopyrimidine;QUINAZOLINE;Benzopyrimidine;Quinazoline 99%;Quinazoline >Quinazoline ,98%;Benzo[d]pyrimidine;benzo[a]pyrimidine
- CBNumber:
- CB8181293
- Molecular Formula:
- C8H6N2
- Molecular Weight:
- 130.15
- MDL Number:
- MFCD00006712
- MOL File:
- 253-82-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Quinazoline 99% | 123323 | 1g | $80.6 |
| Quinazoline 99% | 123323 | 5g | $260 |
| Quinazoline >98.0%(GC)(T) | Q0055 | 1g | $188 |
| Quinazoline Asreported | 288539 | 1g | $322 |
| Quinazoline Asreported | 288539 | 2g | $438 |
| More product size | |||
| Melting point | 46-48 °C (lit.) |
|---|---|
| Boiling point | 243 °C (lit.) |
| Density | 1.2002 (rough estimate) |
| refractive index | 1.6231 (estimate) |
| Flash point | 224 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | H2O: freely soluble |
| pka | 3.43(at 20℃) |
| form | Crystalline Powder, Crystals and/or Chunks |
| color | Yellow to beige to brownish |
| Water Solubility |
H2O: freely soluble organic solvents: soluble |
| Merck | 14,8053 |
| BRN | 109370 |
| InChI | 1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H |
| InChIKey | JWVCLYRUEFBMGU-UHFFFAOYSA-N |
| SMILES | c1ccc2ncncc2c1 |
| CAS DataBase Reference | 253-82-7(CAS DataBase Reference) |
| FDA UNII | UB9QUR18NL |
| NIST Chemistry Reference | Quinazoline(253-82-7) |
| EPA Substance Registry System | Quinazoline (253-82-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-26-23 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Quinazoline price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 123323 | Quinazoline 99% | 253-82-7 | 1g | $80.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 123323 | Quinazoline 99% | 253-82-7 | 5g | $260 | 2026-04-30 | Buy |
| TCI Chemical | Q0055 | Quinazoline >98.0%(GC)(T) | 253-82-7 | 1g | $188 | 2026-04-30 | Buy |
| Usbiological | 288539 | Quinazoline Asreported | 253-82-7 | 1g | $322 | 2026-06-03 | Buy |
| Usbiological | 288539 | Quinazoline Asreported | 253-82-7 | 2g | $438 | 2026-06-03 | Buy |
Quinazoline Chemical Properties,Uses,Production
Chemical Properties
Beige to brownish crystalline powder
Uses
Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.
Definition
ChEBI: A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.
General Description
Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.
Biochem/physiol Actions
Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).
Synthesis
5190-68-1
253-82-7
The general method for the synthesis of quinazoline from 4-chloroquinazoline was as follows: first, the halogenated heterocycle (0.66 mmol) was dissolved in anhydrous THF (13.2 mL) and degassed by drumming argon gas for several minutes. Subsequently, PdCl2 (dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv), and NaBH4 (42.4 mg, 1.12 mmol, 1.7 equiv) were added sequentially. The reaction mixture was stirred at room temperature for an appropriate time under argon protection, after which it was post-treated according to standard methods.
Purification Methods
Purify quinazoline by passage through an activated alumina column in *C6H6 or pet ether (b 40-60o). Distil it under reduced pressure, sublime it under vacuum and crystallise it from pet ether. The picrate has m 188-189o (from MeOH). [Armarego J Appl Chem 11 70 1961, Armarego Quinazolines, Fused Pyrimidines Part I Brown Ed, Wiley-Interscience 1967, Brown Quinazolines Supplement I Taylor Ed, Wiley-Interscience 1996, ISBN 0-471-14565-3; for covalent hydration see Albert & Armarego Adv Heterocycl Chem 4 1 1965, Beilstein 23 H 175, 23 II 177, 23 III/IV 1221.]
References
[1] Journal of Molecular Catalysis A: Chemical, 2014, vol. 393, p. 191 - 209
Quinazoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
View Lastest Price from Quinazoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | Quinazoline
253-82-7
|
$98.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- Quinazoline
253-82-7
- $98.00
- 98%
- Career Henan Chemical Co
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