CI 1020
- CAS No.
- 162256-50-0
- Chemical Name:
- CI 1020
- Synonyms
- CI 1020;PD 156707;3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone;2(5H)-Furanone, 3-(1,3-benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-
- CBNumber:
- CB81873005
- Molecular Formula:
- C28H26O9
- Molecular Weight:
- 506.5
- MDL Number:
- MFCD00867525
- MOL File:
- 162256-50-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CI 1020 | FC20425 | 10mg | $250 |
| CI 1020 | FC20425 | 50mg | $802.5 |
| CI 1020 | B7228 | 1mg | $158 |
| CI 1020 | B7228 | 10mg | $338 |
| CI 1020 | B7228 | 50mg | $1338 |
CI 1020 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FC20425 | CI 1020 | 162256-50-0 | 10mg | $250 | 2026-06-04 | Buy |
| Biosynth | FC20425 | CI 1020 | 162256-50-0 | 50mg | $802.5 | 2026-06-04 | Buy |
| ApexBio Technology | B7228 | CI 1020 | 162256-50-0 | 1mg | $158 | 2026-05-06 | Buy |
| ApexBio Technology | B7228 | CI 1020 | 162256-50-0 | 10mg | $338 | 2026-05-06 | Buy |
| ApexBio Technology | B7228 | CI 1020 | 162256-50-0 | 50mg | $1338 | 2026-05-06 | Buy |
CI 1020 Chemical Properties,Uses,Production
Uses
A novel endothelin-A receptor antagonist, in hypoxic pulmonary hypertension.
Biological Activity
Highly selective, orally active, non-peptide endothelin-A receptor (ET A ) antagonist (IC 50 values are 0.3 and 480 nM for ET A and ET B receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.
in vivo
CI-1020 (30 mg/kg, p.o.) represents full inhibition of the ET-A and has no significant effect on basal blood pressure in normotensive rats[2].
CI-1020 (40 mg/kg, p.o.) attenuates established pulmonary hypertension in rats previously exposed to chronic hypoxia[4].
| Animal Model: | normal rats [2] |
| Dosage: | 30 mg/kg |
| Administration: | oral administration (p.o.) |
| Result: | Inhibited the ET-A and has no significant effect on basal blood pressure in normotensive rats. |
| Animal Model: | basal blood pressure in normotensive rats[4] |
| Dosage: | 40 mg/kg/day |
| Administration: | oral administration (p.o.) |
| Result: | Reduced the increase in RV/LV+S and the percentage DEL induced by chronic hypoxia. Lowered the increase in pulmonary resistance in isolated perfused lungs significantly. |
IC 50
ETA: 0.3 nM (IC50)
CI 1020 Preparation Products And Raw materials
Raw materials
Preparation Products
CI 1020 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai Zhixin Chemical Technology Co., Ltd. | 18701958033 | shzxchem@163.com | China | 655 | 58 |
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