H2N-PEG2-Propyne
- CAS No.
- 944561-44-8
- Chemical Name:
- H2N-PEG2-Propyne
- Synonyms
- 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine;Propargyl-PEG2-NH2;HC≡C-CH2-PEG2-NH2;2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanamine;2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine hydrochloride;NH2-PEG2-Al;Alkyne-PEG2-NH2;H2N-PEG2-Propyne;Alkyne-PEG2-amine;Propyne-PEG2-amine
- CBNumber:
- CB82546863
- Molecular Formula:
- C7H13NO2
- Molecular Weight:
- 143.18
- MDL Number:
- MFCD19160595
- MOL File:
- 944561-44-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-[2-(2-Propynyloxy)ethoxy]ethylamine >98.0%(GC)(T) | P2225 | 1g | $82 |
| 2-[2-(2-Propynyloxy)ethoxy]ethylamine >98.0%(GC)(T) | P2225 | 5g | $296 |
| H2N-PEG2-Propyne | FP73041 | 1g | $150 |
| H2N-PEG2-Propyne | FP73041 | 2g | $181.72 |
| H2N-PEG2-Propyne | FP73041 | 5g | $337.5 |
| More product size | |||
| Boiling point | 213.8±20.0 °C(Predicted) |
|---|---|
| Density | 0.992±0.06 g/cm3(Predicted) |
| refractive index | 1.4590 to 1.4630 |
| Flash point | 88° |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO:100.0(Max Conc. mg/mL);698.37(Max Conc. mM) |
| form | clear liquid |
| pka | 8.72±0.10(Predicted) |
| color | Colorless to Almost colorless |
| Appearance | colorless to yellow liquid |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501 |
| RIDADR | UN 2735 8/PG II |
| HS Code | 2922.19.9690 |
| HazardClass | 8 |
| PackingGroup | II |
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
H2N-PEG2-Propyne price More Price(122)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P2225 | 2-[2-(2-Propynyloxy)ethoxy]ethylamine >98.0%(GC)(T) | 944561-44-8 | 1g | $82 | 2026-04-30 | Buy |
| TCI Chemical | P2225 | 2-[2-(2-Propynyloxy)ethoxy]ethylamine >98.0%(GC)(T) | 944561-44-8 | 5g | $296 | 2026-04-30 | Buy |
| Biosynth | FP73041 | H2N-PEG2-Propyne | 944561-44-8 | 1g | $150 | 2026-06-04 | Buy |
| Biosynth | FP73041 | H2N-PEG2-Propyne | 944561-44-8 | 2g | $181.72 | 2026-06-04 | Buy |
| Biosynth | FP73041 | H2N-PEG2-Propyne | 944561-44-8 | 5g | $337.5 | 2026-06-04 | Buy |
H2N-PEG2-Propyne Chemical Properties,Uses,Production
Description
Propargyl-PEG2-amine is a crosslinker that is reactive with NHS esters, carbonyls (carboxylic acid, ketone, aldehyde). The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reaction to form a stable triazole linkage.
Uses
2-[2-(2-Propynyloxy)ethoxy]ethylamine is used in preparation of RSV F protein inhibitors conjugated to Fc variants and albumins.
Synthesis
1245006-63-6
944561-44-8
The general procedure for the synthesis of 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethylamine from the compound (CAS:1245006-63-6) is as follows: General method: polymer-loaded triphenylphosphine (1.15 eq.) was added to an anhydrous tetrahydrofuran (THF) solution of azide alkynes S3. Subsequently, the reaction mixture was stirred at room temperature for 48 hours. Next, deionized water (1 mL) was added to the flask and the resulting mixture was continued to be stirred at room temperature for 48 hours. Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth to collect insoluble solids and washed with ethyl acetate (25 mL). Finally, the combined filtrates were concentrated under reduced pressure to give the target product aminoalkynes 6.
IC 50
Non-cleavable Linker; PEGs
References
[1] Molecules, 2013, vol. 18, # 9, p. 11639 - 11657
[2] Journal of the American Chemical Society, 2010, vol. 132, # 36, p. 12711 - 12716
[3] Drug Design, Development and Therapy, 2018, vol. 12, p. 987 - 995
[4] Journal of Porphyrins and Phthalocyanines, 2013, vol. 17, # 1-2, p. 104 - 117
H2N-PEG2-Propyne Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8613588737631 | chem1022@hengdian-group.com | China | 1478 | 58 |
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | changaiwei@sinopeg.com | China | 1125 | 58 |
View Lastest Price from H2N-PEG2-Propyne manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Propargyl-PEG2-amine
944561-44-8
|
10g | TargetMol Chemicals Inc. | ||||
 |
2026-02-05 | Propargyl-PEG2-NH2
944561-44-8
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2025-06-07 | Propargyl-PEG2-amine
944561-44-8
|
25g | >98.00% | 25g | Xian confluore Biological Technology Co., Ltd. |
-
- Propargyl-PEG2-amine
944561-44-8
- $0.00
- TargetMol Chemicals Inc.
-
- Propargyl-PEG2-NH2
944561-44-8
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Propargyl-PEG2-amine
944561-44-8
- $0.00
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
