UNC2250
- CAS No.
- 1493694-70-4
- Chemical Name:
- UNC2250
- Synonyms
- CS-1346;UNC2250;UNC2250 USP/EP/BP;UNC2250(UNC 2250);UNC2250, 10 mM in DMSO;trans-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-ol;(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol;Cyclohexanol, 4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-, trans-
- CBNumber:
- CB82677545
- Molecular Formula:
- C24H36N6O2
- Molecular Weight:
- 440.58
- MDL Number:
- MFCD27992060
- MOL File:
- 1493694-70-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| UNC2250 ≥98% (HPLC) | SML3620 | 5MG | $87.1 |
| UNC2250 ≥98% (HPLC) | SML3620 | 25MG | $351 |
| UNC2250 ≥98% | 17703 | 1mg | $36 |
| UNC2250 ≥98% | 17703 | 5mg | $120 |
| UNC2250 ≥98% | 17703 | 10mg | $203 |
| More product size | |||
| Melting point | 207-210oC |
|---|---|
| Boiling point | 657.4±65.0 °C(Predicted) |
| Density | 1.224±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly) |
| pka | 15.02±0.40(Predicted) |
| form | Solid |
| color | Pale Yellow to Yellow |
| InChIKey | HSYSSKFCQHXOBP-MXVIHJGJSA-N |
| SMILES | N4(CCOCC4)Cc1cnc(cc1)c2c(nc(nc2)NCCCC)N[C@@H]3CC[C@H](CC3)O |
| UNSPSC Code | 12352200 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
UNC2250 price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3620 | UNC2250 ≥98% (HPLC) | 1493694-70-4 | 5MG | $87.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3620 | UNC2250 ≥98% (HPLC) | 1493694-70-4 | 25MG | $351 | 2026-04-30 | Buy |
| Cayman Chemical | 17703 | UNC2250 ≥98% | 1493694-70-4 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 17703 | UNC2250 ≥98% | 1493694-70-4 | 5mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 17703 | UNC2250 ≥98% | 1493694-70-4 | 10mg | $203 | 2026-04-30 | Buy |
UNC2250 Chemical Properties,Uses,Production
Description
Tyro3, Axl, and Mer are members of the TAM family of receptor tyrosine kinases that have signaling roles in normal and malignant cells. UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC50 value of 9.8 nM. It is selective for Mer over a panel of both tyrosine and serine-threonine kinases, including Tyro3 and Axl. UNC2250 also inhibits ligand-dependent phosphorylation of a chimeric EGFR-Mer protein and blocks colony formation in soft agar cultures of BT-12 rhabdoid tumor and Colo699 NSCLC cell lines. UNC2250 displays good pharmacokinetic properties in mice following intravenous or oral administration.
Uses
(1r,4r)-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol inhibits steady-state phosphorylation of endogenous Mer and blocks ligand-stimulated activation of a chimeric EGFR-Mer protein. (1r,4r)-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol also decreases colony-forming potential in rhabdoid and NSCLC tumor cells.
IC 50
Axl; Mer
References
[1] zhang w, zhang d, stashko m a, et al. pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new mer kinase inhibitors. journal of medicinal chemistry, 2013, 56(23): 9683-9692.
UNC2250 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27033 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 |
