METHYL 6-AMINO-5-BROMOPICOLINATE
- CAS No.
- 178876-82-9
- Chemical Name:
- METHYL 6-AMINO-5-BROMOPICOLINATE
- Synonyms
- METHYL 6-AMINO-5-BROMOPYRIDINE-2-CARBOXYLATE;methyl 6-amino-5-bromopicolinate;METHYL 6-AMINO-5-BROMOPICOLINATE ISO 9001：2015 REACH;6-AMino-5-broMopyridine-2-carboxylic Acid Methyl Ester;2-Pyridinecarboxylic acid, 6-amino-5-bromo-, methyl ester
- CBNumber:
- CB8348980
- Molecular Formula:
- C7H7BrN2O2
- Molecular Weight:
- 231.05
- MDL Number:
- MFCD08062950
- MOL File:
- 178876-82-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 6-amino-5-bromopyridine-2-carboxylate 97% | OR61091 | 250mg | $22 |
| Methyl 6-amino-5-bromopyridine-2-carboxylate 97% | OR61091 | 1g | $63 |
| Methyl 6-amino-5-bromopicolinate | 153558 | 1.00g | $556 |
| Methyl 6-amino-5-bromopicolinate | 153558 | 5.00g | $1480 |
| Methyl 6-amino-5-bromopicolinate 95+% | M32000 | 100mg | $25 |
| More product size | |||
| Melting point | 143-145 °C |
|---|---|
| Boiling point | 359.2±37.0 °C(Predicted) |
| Density | 1.662 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -0.23±0.10(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C7H7BrN2O2/c1-12-7(11)5-3-2-4(8)6(9)10-5/h2-3H,1H3,(H2,9,10) |
| InChIKey | OQUCMNQHZFOMPC-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC(N)=C(Br)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| HS Code | 2933399990 |
METHYL 6-AMINO-5-BROMOPICOLINATE price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR61091 | Methyl 6-amino-5-bromopyridine-2-carboxylate 97% | 178876-82-9 | 250mg | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR61091 | Methyl 6-amino-5-bromopyridine-2-carboxylate 97% | 178876-82-9 | 1g | $63 | 2026-06-04 | Buy |
| Matrix Scientific | 153558 | Methyl 6-amino-5-bromopicolinate | 178876-82-9 | 1.00g | $556 | 2026-05-18 | Buy |
| Matrix Scientific | 153558 | Methyl 6-amino-5-bromopicolinate | 178876-82-9 | 5.00g | $1480 | 2026-05-18 | Buy |
| Synthonix | M32000 | Methyl 6-amino-5-bromopicolinate 95+% | 178876-82-9 | 100mg | $25 | 2026-05-06 | Buy |
METHYL 6-AMINO-5-BROMOPICOLINATE Chemical Properties,Uses,Production
Uses
Methyl 6-amino-5-bromopicolinate is used in the preparation of aminopyridinamides as sodium channel modulators.
Synthesis
36052-26-3
178876-83-0
178876-82-9
d) Synthesis of methyl 6-amino-5-bromopyridine-2-carboxylate: Methyl 6-aminopyridine-2-carboxylate (10 g, 66.0 mmol) was dissolved in chloroform (450 mL) at room temperature, and a chloroform (100 mL) solution of bromine (3.4 mL, 66.0 mmol) was slowly added. The reaction mixture was stirred for 40 hours, then diluted with chloroform and washed sequentially with saturated sodium thiosulfate solution and water. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure, and the residue was purified by silica gel column chromatography using ethyl acetate/hexane as eluent to afford methyl 5-bromo-6-aminopyridine-2-carboxylate as a yellow solid (3.3 g, 22% yield).MS ESI (m/e): 231.0 [(M + H)+].1H NMR (CDCl3, 400 MHz): δ ( ppm) = 7.76 (d, J = 7.88 Hz, 1H), 7.34 (d, J = 7.92 Hz, 1H), 5.23 (s, 2H), 3.94 (s, 3H). (d) Isolation of methyl 6-amino-3-bromopyridine-2-carboxylate: In step d), the isomer methyl 6-amino-3-bromopyridine-2-carboxylate was isolated as a by-product to give methyl 6-amino-3-bromopyridine-2-carboxylate (3.0 g, 19% yield).MS ESI (m/e): 231.2 [(M + H)+].1H NMR (CDCl3, 400 MHz): δ (ppm) = 7.60 (d , J = 8.72 Hz, 1H), 6.47 (d, J = 7.88 Hz, 1H), 4.71 (s, 2H), 3.94 (s, 3H).
References
[1] Journal of Organic Chemistry, 1996, vol. 61, # 14, p. 4623 - 4633
[2] Organic Process Research and Development, 2010, vol. 14, # 1, p. 263 - 271
[3] Tetrahedron Letters, 2010, vol. 51, # 38, p. 5035 - 5037
[4] Patent: US2011/190269, 2011, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2011/92272, 2011, A1. Location in patent: Page/Page column 129; 130
METHYL 6-AMINO-5-BROMOPICOLINATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1299 | 58 |
View Lastest Price from METHYL 6-AMINO-5-BROMOPICOLINATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-17 | methyl 6-amino-5-bromo-pyridine-2-carboxylate
178876-82-9
|
$1.10-9.90 | 1KG | 99% min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-06-25 | METHYL 6-AMINO-5-BROMOPICOLINATE
178876-82-9
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-03 | METHYL 6-AMINO-5-BROMOPICOLINATE
178876-82-9
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- methyl 6-amino-5-bromo-pyridine-2-carboxylate
178876-82-9
- $1.10-9.90
- 99% min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- METHYL 6-AMINO-5-BROMOPICOLINATE
178876-82-9
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- METHYL 6-AMINO-5-BROMOPICOLINATE
178876-82-9
- $1.00
- 99%
- Career Henan Chemical Co
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