MOPSO
- CAS No.
- 68399-77-9
- Chemical Name:
- MOPSO
- Synonyms
- MOPSO Buffer;3-(N-MORPHOLINO)-2-HYDROXYPROPANESULFONIC ACID;MOPSO FREE ACID;2-HYDROXY-3-MORPHOLINOPROPANESULFONIC ACID;3-MORPHOLINO-2-HYDROXYPROPANESULFONIC ACID;β-Hydroxy-4-morpholinepropanesulfonic acid;MOPSO;freeacid,buffergrade;LABOTEST-BB LT00452982;MOPSO,BIOLOGICALBUFFER
- CBNumber:
- CB8400709
- Molecular Formula:
- C7H15NO5S
- Molecular Weight:
- 225.26
- MDL Number:
- MFCD00009629
- MOL File:
- 68399-77-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| MOPSO ≥99% (titration) | M8389 | 25g | $67.5 |
| MOPSO ≥99% (titration) | M8389 | 100g | $172 |
| 2-Hydroxy-3-morpholinopropanesulfonic Acid >98.0%(T) | H0671 | 25g | $29 |
| MOPSO Free Acid ≥99% | M4620 | 100g | $119 |
| MOPSO Free Acid ≥99% | M4620 | 500g | $203 |
| More product size | |||
| Melting point | 275-280 °C (dec.) |
|---|---|
| Density | 1.416±0.06 g/cm3(Predicted) |
| refractive index | 1.540 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | H2O: 0.5 M at 20 °C, clear |
| pka | pK1:6.75 (37°C) |
| form | Crystalline Powder |
| color | White |
| PH Range | 6.2 - 7.6 |
| Odor | Odorless |
| PH | 6.2-7.6 |
| Water Solubility | Water solubility under desired conditions ca.112,6 g/L at 20°C. |
| BRN | 1109697 |
| Major Application | diagnostic assay manufacturing |
| InChI | InChI=1S/C7H15NO5S/c9-7(6-14(10,11)12)5-8-1-3-13-4-2-8/h7,9H,1-6H2,(H,10,11,12) |
| InChIKey | NUFBIAUZAMHTSP-UHFFFAOYSA-N |
| SMILES | C(N1CCOCC1)C(O)CS(O)(=O)=O |
| CAS DataBase Reference | 68399-77-9(CAS DataBase Reference) |
| FDA UNII | 6XB7PS9THL |
| EPA Substance Registry System | 4-Morpholinepropanesulfonic acid, .beta.-hydroxy- (68399-77-9) |
| UNSPSC Code | 12161700 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 1 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
MOPSO price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M8389 | MOPSO ≥99% (titration) | 68399-77-9 | 25g | $67.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | M8389 | MOPSO ≥99% (titration) | 68399-77-9 | 100g | $172 | 2026-04-30 | Buy |
| TCI Chemical | H0671 | 2-Hydroxy-3-morpholinopropanesulfonic Acid >98.0%(T) | 68399-77-9 | 25g | $29 | 2026-04-30 | Buy |
| Usbiological | M4620 | MOPSO Free Acid ≥99% | 68399-77-9 | 100g | $119 | 2026-06-03 | Buy |
| Usbiological | M4620 | MOPSO Free Acid ≥99% | 68399-77-9 | 500g | $203 | 2026-06-03 | Buy |
MOPSO Chemical Properties,Uses,Production
Description
MOPSO Free Acid is a zwitterionic aminosulfonate buffer with a similar structure to MOPS and a useful pH range of 6.5 - 7.9. It may be used as a buffer component in various biological applications including DNA gel electrophoresis. It has been found that MOPSO buffer combined excellent pH stabilization at pH 7·00 and limited color alteration by testing the color changes of raw sugar solutions so that MOPSO buffer and three glass-fiber filters in series can be used to reduce the effect of pH and turbidity on color measurement of raw sugar solution[1]. The activity of the endo-α-D-mannosidase enzyme in MOPSO buffers at pH 7.0 is increased very much over buffers like HEPES or HEPPS. This buffer also has been employed as a buffer component of charcoal yeast extract medium[2]. However, morpholine family buffers (MES, MOPS, and MOPSO) have been reported to interact with the trivalent metal ions Cr3+ and Fe3+. Therefore, extensive testing is required before using MAPSO.
Chemical Properties
white crystalline powder
Uses
MOPSO is a biological buffer also referred to as a second generation “Good′s” buffer which displays improved solubility compared to traditional “Good′s” buffers. The pKa of MOPSO is 6.9 which make it an ideal candidate for buffer formulations which require a pH slightly below physiological to maintain a stable environment in solution. MOPSO is considered to be non-toxic to culture cell lines and provides high-solution clarity.
MOPSO can be used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream) and diagnostic reagents.
Uses
MOPSO is a buffer that works in the 6-7 pH range. Used in pharmaceutical synthesis.
Definition
ChEBI: 3-(n-morpholino)-2-hydroxypropanesulfonic acid is a member of morpholines.
References
[1] Ahmedna M, et al. Use of filtration and buffers in raw sugar colour measurements. Journal of the Science of Food and Agriculture, 1997; 75: 109-116.
[2] Taha M, et al. Interactions of Biological Buffers with Macromolecules: The Ubiquitous “Smart” Polymer PNIPAM and the Biological Buffers MES, MOPS, and MOPSO. Macromolecules, 2011; 44: 8575–858.
MOPSO Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Genemill Biotechnology Co.,Ltd | +8615862502491 | aimeegao@genemill.com | China | 39 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3992 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046; | sales01@watsonbiotech.cn | China | 5733 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
Related articles
- Synthesis and Application of 3-(N-Morpholino)-2-hydroxypropanesulfonic acid (MOPSO)
- MOPSO is the most widely used in various biological and biochemical studies and MOPSO has three synthetic method.
- Oct 28，2025
View Lastest Price from MOPSO manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-05 | MOPSO
68399-77-9
|
1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd | ||
 |
2026-06-05 | MOPSO
68399-77-9
|
1KG | 99%-101% | 100KG | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-04-21 | 3-(N-Morpholino)-2-Hydroxypropanesulfonic acid (MOPSO)
68399-77-9
|
25kg | 99% | 300tons/year | Wuhan Hugarise New Material Co.,Ltd |
-
- MOPSO
68399-77-9
- 99%
- Watson Biotechnology Co.,Ltd
-
- MOPSO
68399-77-9
- $0.00
- 99%-101%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-(N-Morpholino)-2-Hydroxypropanesulfonic acid (MOPSO)
68399-77-9
- $0.00
- 99%
- Wuhan Hugarise New Material Co.,Ltd
